Predictors of treatment utilization and barriers to treatment utilization among individuals with lifetime cannabis use disorder in the United States

Kerridge, Bradley T.; Mauro, Pia M.; Chou, S. Patricia; Saha, Tulshi D.; Pickering, Roger P.; Fan, Arthur Yin; Grant, Bridget F.; Hasin, Deborah S.

doi:10.1016/j.drugalcdep.2017.09.032

Cited by 112 publications

(34 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…, it was unclear if “neuroprotection” was involved in increased survival time because an increased animal survival time following systemic administration of opioid ligands does not necessarily indicate “neuroprotection”. Since DOR is widely distributed in the central and peripheral systems including the heart and kidney [41, 44, 49], an intravenous ligand may elicit systemic effects through many complex and varied mechanisms. The change in survival time may have resulted from the diverse effects of opioid ligands on various organs and organ systems, especially in the heart and kidney [64-71].…”

Section: Opioid Receptors and Neuroprotection: Major Controversies Inmentioning

confidence: 99%

Neuroprotection Against Hypoxic/Ischemic Injury: δ-Opioid Receptors and BDNF-TrkB Pathway

Sheng¹,

Huang²,

Ren³

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

The delta-opioid receptor (DOR) is one of three classic opioid receptors in the opioid system. It was traditionally thought to be primarily involved in modulating the transmission of messages along pain signaling pathway. Although there were scattered studies on its other neural functions, inconsistent results and contradicting conclusions were found in past literatures, especially in terms of DOR’s role in a hypoxic/ischemic brain. Taking inspiration from the finding that the turtle brain exhibits a higher DOR density and greater tolerance to hypoxic/ischemic insult than the mammalian brain, we clarified DOR’s specific role in the brain against hypoxic/ischemic injury and reconciled previous controversies in this aspect. Our serial studies have strongly demonstrated that DOR is a unique neuroprotector against hypoxic/ischemic injury in the brain, which has been well confirmed in current research. Moreover, mechanistic studies have shown that during acute phases of hypoxic/ischemic stress, DOR protects the neurons mainly by the stabilization of ionic homeostasis, inhibition of excitatory transmitter release, and attenuation of disrupted neuronal transmission. During prolonged hypoxia/ischemia, however, DOR neuroprotection involves a variety of signaling pathways. More recently, our data suggest that DOR may display its neuroprotective role via the BDNF-TrkB pathway. This review concisely summarizes the progress in this field.

show abstract

Section: Opioid Receptors and Neuroprotection: Major Controversies Inmentioning

confidence: 99%

Neuroprotection Against Hypoxic/Ischemic Injury: δ-Opioid Receptors and BDNF-TrkB Pathway

Sheng¹,

Huang²,

Ren³

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Rates of cannabis use and cannabis use disorder (CUD) are rising in North America, and CUD is a common presenting issue in addiction treatment [ 20 , 32 ]. However, treatment-seeking rates are low relative to the numbers of people with the disorder [ 17 ] and rates of natural recovery are significant [ 3 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Insights from individuals successfully recovered from cannabis use disorder: natural versus treatment-assisted recoveries and abstinent versus moderation outcomes

Hodgins

Stea

2018

Addict Sci Clin Pract

View full text Add to dashboard Cite

BackgroundIncreasing understanding of the pathways and processes of recovery from cannabis use disorder may help in designing effective and attractive interventions to promote recovery. We report insights from individuals who had successfully recovered from cannabis use disorder with a variety of pathways. Recovered individuals describe their perceptions of why they developed the problem, why they were successful in recovering, and the advice they would offer to individuals with similar problems.MethodsMedia announcements were used to recruit 119 volunteers who met lifetime but not past year criteria for cannabis use disorder. Participants were asked open-ended questions which were content analyzed and compared between individuals who whose recoveries were treatment-assisted (45%) versus natural (55%) and between individuals who were abstinent (57%) versus those who continued non-problematic consumption (43%).ResultsParticipants most frequently described their problems as having developed due to the use of cannabis to cope, because of environmental and social influences, and enjoyment of the positive effects. Success in recovery was attributed to focusing on reasons for change, goal commitment to change, and conquering denial/self-deception. Treatment-assisted participants were more likely to perceive that they overcame their cannabis problem due to treatment/self-help and conquering underlying issues, whereas naturally recovered participants were more likely to describe focusing on reasons for change, will power, and lost enjoyment/lifestyle change. Treatment-assisted participants were more likely to recommend seeking help/social support and naturally recovered participants were more likely to endorse reflecting on reasons for change, engaging in hobbies/distracting activities, and stimulus control/avoidance/change social environment. The majority recommended professional treatment (79.1%) and self-help materials (76.9%), and a little over half (53.2%) would also recommend natural recovery.ConclusionsThese insights from people with lived experience further support previous research that treatment-assisted and natural recoveries are for the most part similar with respect to the recovery process. However, participants, whether or not they had had treatment involvement, recommended the use of treatment and self-help materials to sharpen their focus on the reasons to change and to enhance their commitment to change. At the same time, they saw value in the efforts of individuals to recovery without help.Electronic supplementary materialThe online version of this article (10.1186/s13722-018-0118-0) contains supplementary material, which is available to authorized users.

show abstract

“…The items used to assess the barriers to treatment were modified from the treatment utilization section of National Institute on Alcohol Abuse and Alcoholism (NESARC) questionnaire. The NESARC is a national survey conducted by the National Institute on Alcohol Abuse and Alcoholism (Grant et al, ) and has been widely cited (Cohen, Feinn, Arias, & Kranzler, ; Kerridge et al, ; Vaeth, Wang‐Schweig, & Caetano, ). Table detailed the items.…”

Section: Methodsmentioning

confidence: 99%

Leveraging social media to explore the barriers to treatment among individuals with depressive symptoms

Szlyk

Deng

et al. 2020

Depress Anxiety

View full text Add to dashboard Cite

Background: Individuals with depression may not seek treatment for their symptoms due to several types of barriers to treatment. In support of the growing research on mental health care access and the role of social media, this study aimed to increase knowledge of these barriers among social media users.Methods: Participants were recruited from several social media platforms, including Instagram, Facebook, Twitter, Reddit, Tumblr, and online depression forums. Eligible participants had endorsed having posted about feeling sad or depressed on social media, or followed social media groups that post about depression-related topics.Participants completed an online survey about their depression symptoms, interest in treatment, and potential barriers to accessing treatment.Results: Of the participants reaching criteria for depression, those with major depression were more likely to seek out treatment, to report an unmet need for treatment, and have a higher risk of suicide. For participants with major depression, barriers to treatment were more likely to be attitudinal, while participants with mild depression experienced more structural barriers.Conclusions: This study demonstrates several barriers to treatment that occur for individuals struggling with depression, and that online platforms are effective mediums to recruit individuals with depression symptoms who seek mental health support.

show abstract

Predictors of treatment utilization and barriers to treatment utilization among individuals with lifetime cannabis use disorder in the United States

Cited by 112 publications

References 45 publications

Neuroprotection Against Hypoxic/Ischemic Injury: δ-Opioid Receptors and BDNF-TrkB Pathway

Neuroprotection Against Hypoxic/Ischemic Injury: δ-Opioid Receptors and BDNF-TrkB Pathway

Insights from individuals successfully recovered from cannabis use disorder: natural versus treatment-assisted recoveries and abstinent versus moderation outcomes

Leveraging social media to explore the barriers to treatment among individuals with depressive symptoms

Contact Info

Product

Resources

About