Antioxidant activity and controlled drug delivery potential of tragacanth gum-cl- poly (lactic acid-co-itaconic acid) hydrogel

Gupta, Vinod Kumar; Sood, Swadeep; Agarwal, Shilpi; Saini, Adesh K.; Pathania, Deepak

doi:10.1016/j.ijbiomac.2017.10.138

Cited by 53 publications

(16 citation statements)

References 53 publications

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“…Itaconic acid has been intensively studied as an alternative co-monomer for acrylic acid and methacrylic acid [89]. For example, Sood et al (2017) [90] and Gupta et al (2018) [91] reported the synthesis of a biodegradable hydrogel of poly-(lactic acid-co-itaconic acid) copolymerized using the microwave-assisted technique for drug delivery purposes [90,91].…”

Section: Synthetically Produced Bio-polyestersmentioning

confidence: 99%

Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

et al. 2020

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Environmental impacts and consumer concerns have necessitated the study of bio-based materials as alternatives to petrochemicals for packaging applications. The purpose of this review is to summarize synthetic and non-synthetic materials feasible for packaging and textile applications, routes of upscaling, (industrial) applications, evaluation of sustainability, and end-of-life options. The outlined bio-based materials include polylactic acid, polyethylene furanoate, polybutylene succinate, and non-synthetically produced polymers such as polyhydrodyalkanoate, cellulose, starch, proteins, lipids, and waxes. Further emphasis is placed on modification techniques (coating and surface modification), biocomposites, multilayers, and additives used to adjust properties especially for barriers to gas and moisture and to tune their biodegradability. Overall, this review provides a holistic view of bio-based packaging material including processing, and an evaluation of the sustainability of and options for recycling. Thus, this review contributes to increasing the knowledge of available sustainable bio-based packaging material and enhancing the transfer of scientific results into applications.

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Section: Synthetically Produced Bio-polyestersmentioning

confidence: 99%

Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

et al. 2020

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“…TG grafted with poly(lactic acid-co-itaconic acid) based hydrogel was synthesized through graft copolymerization reaction using microwave assisted technique. [50] Influence of various conditions, that is, Figure 5. Schematic representation of the water channel formation in TG and GTG matrix.…”

Section: Infection-resistant Materialsmentioning

confidence: 99%

“…TG grafted with poly(lactic acid– co ‐itaconic acid) based hydrogel was synthesized through graft copolymerization reaction using microwave assisted technique. [ 50 ] Influence of various conditions, that is, temperature and time on loading and release of amoxicillin from the hydrogel were evaluated under various physiological conditions. Maximum drug release was seen in case of pH 2.2, total 96% of loaded amoxicillin was released at this pH.…”

Section: Applications Of Functional Tragacanth Gummentioning

confidence: 99%

Smart Designing of Tragacanth Gum by Graft Functionalization for Advanced Materials

Verma¹,

Pathania

Anjum³

et al. 2020

Macro Materials & Eng

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Tragacanth gum is a novel polysaccharide which offers interesting features in terms of high hydrophilicity, good biocompatibility, and biodegradability. The engineering of hydrogels requires careful designing of their macromolecular structures so that desirable features may be incorporated into the material. Graft polymerization has come up as an interesting approach to develop molecules for drug delivery, wound care systems, and infection‐resistant materials. The most important aspect of graft functionalization is the proper control over physico‐chemical properties of the grafted matrix. The extent of functionalization may be governed by the grafting parameters and may lead to the chemical designing of the molecule in a controlled manner. This opens up enormous possibilities of developing materials for a wide range of applications as advanced materials.

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“…Accordingly, a variety of chemicals and drugs were loaded into different GT-based constructs (e.g., nanogels, hydrogels, and nanofibers) and relevant composites to be delivered to desirable sites via oral or other administration routes [70]. Antibacterial, anti-cancer, anti-inflammatory, and antioxidant agents are among the most delivered therapeutics by GT and its composites [49,71,72]. For antibacterial applications, GT in the form of hydrogels and nanogels has been widely used as a delivery platform for organic (e.g., plant extracts) and inorganic (silver nanoparticles) substances [73,74].…”

Section: Gt For Drug Delivery Strategiesmentioning

confidence: 99%

Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

et al. 2021

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The use of naturally occurring materials in biomedicine has been increasingly attracting the researchers’ interest and, in this regard, gum tragacanth (GT) is recently showing great promise as a therapeutic substance in tissue engineering and regenerative medicine. As a polysaccharide, GT can be easily extracted from the stems and branches of various species of Astragalus. This anionic polymer is known to be a biodegradable, non-allergenic, non-toxic, and non-carcinogenic material. The stability against microbial, heat and acid degradation has made GT an attractive material not only in industrial settings (e.g., food packaging) but also in biomedical approaches (e.g., drug delivery). Over time, GT has been shown to be a useful reagent in the formation and stabilization of metal nanoparticles in the context of green chemistry. With the advent of tissue engineering, GT has also been utilized for the fabrication of three-dimensional (3D) scaffolds applied for both hard and soft tissue healing strategies. However, more research is needed for defining GT applicability in the future of biomedical engineering. On this object, the present review aims to provide a state-of-the-art overview of GT in biomedicine and tries to open new horizons in the field based on its inherent characteristics.

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Antioxidant activity and controlled drug delivery potential of tragacanth gum-cl- poly (lactic acid-co-itaconic acid) hydrogel

Cited by 53 publications

References 53 publications

Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

Smart Designing of Tragacanth Gum by Graft Functionalization for Advanced Materials

Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

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