Thrombose de valve post-TAVI

Leguay, Denis; Duval, Sébastien; LeRoux, Michele; Monnier, A. Le; Davienne, Y.; Brasselet, Camille

doi:10.1016/j.ancard.2017.10.009

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Slow blood flow Turbulence Incomplete apposition [80,81], Hypercoagulability [82,83], Turbulence [84,85], and Incomplete apposition [86,87] can be found through the cited sources. See [2] for a more detailed list of factors involved in prosthetic valve thrombosis.…”

Section: Mitral Valvementioning

confidence: 99%

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Management of Intracranial Hemorrhage in the Setting of Mechanical Heart Valve Replacement Therapy

2023

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The management of an intracranial hemorrhage in patients receiving anticoagulant therapy presents a significant challenge for medical professionals. Anticoagulant treatment is intended to prevent blood clotting, but it can worsen active brain bleeds. Despite this risk, avoiding the prothrombotic state caused by mechanical heart valves remains crucial. Guidelines on managing this issue are currently lacking, prompting a review that delves into embryonic development and anatomical functions of heart valves, valve replacement therapy for diseased valves, and the need for anticoagulants. Ultimately, recent literature and cases inform discussion regarding how best to manage intracranial hemorrhages in patients with mechanical heart valves. The expectation is that this examination will offer valuable perspectives on the handling of intracranial bleeding among individuals with mechanical heart valves and stimulate additional investigations in this intricate domain, particularly through the lens of applied mechanics.

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Section: Mitral Valvementioning

confidence: 99%

“…Hemostatic and hemodynamic factors involved in the development of prosthetic valve thromboses. Additional information regarding Slow blood flow[80,81], Hypercoagulability[82,83], Turbulence[84,85], and Incomplete apposition[86,87] can be found through the cited sources. See[2] for a more detailed list of factors involved in prosthetic valve thrombosis.…”

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confidence: 99%

Management of Intracranial Hemorrhage in the Setting of Mechanical Heart Valve Replacement Therapy

2023

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“…42 The assumed pathophysiological mechanisms of leaflet thrombosis include reduced blood flow between the Valsalva sinuses and bioprosthetic leaflets, tissue fissuring, endothelium exposure and incomplete prosthesis expansion or apposition, which in turn delays the process of endothelisation. 50,51 Several factors are independent predictors of leaflet thrombosis: body mass index >30 kg/m 2 , large valve diameter (>28 mm), balloon-expandable prostheses, valve-in-valve procedure and single antiplatelet therapy (SAPT) administration. 52,53 Interestingly, in comparison with OAC, SAPT and DAPT are less effective on these thrombi in many cases because they develop in a low shear-stress setting that often involves thrombinmediated processes rather than platelet aggregation (Figure 1).…”

Section: Leaflet Thrombosismentioning

confidence: 99%

Anticoagulation after Transcatheter Aortic Valve Implantation: Current Status

Greco

Capodanno

2020

Interv Cardiol

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Transcatheter aortic valve implantation (TAVI) is the standard of care for symptomatic severe aortic stenosis. Antithrombotic therapy is required after TAVI to prevent thrombotic complications but it increases the risk of bleeding events. Current clinical guidelines are mostly driven by expert opinion and therefore yield low-grade recommendations. The optimal antithrombotic regimen following TAVI has yet to be determined and several randomised controlled trials assessing this issue are ongoing. The purpose of this article is to critically explore the impact of antithrombotic drugs, especially anticoagulants, on long-term clinical outcomes following successful TAVI.

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Optimal Anticoagulation on TAVI Patients Based on Thrombotic and Bleeding Risk and the Challenge Beyond: A Systematic Review and Meta-Analysis

Tsoumas

Λαμπρόπουλος

2023

Current Problems in Cardiology

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Thrombose de valve post-TAVI

Cited by 4 publications

References 28 publications

Management of Intracranial Hemorrhage in the Setting of Mechanical Heart Valve Replacement Therapy

Management of Intracranial Hemorrhage in the Setting of Mechanical Heart Valve Replacement Therapy

Anticoagulation after Transcatheter Aortic Valve Implantation: Current Status

Optimal Anticoagulation on TAVI Patients Based on Thrombotic and Bleeding Risk and the Challenge Beyond: A Systematic Review and Meta-Analysis

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