The association between murine double minute 2 (MDM2) rs2279744 and endometrial cancer risk in a Chinese Han population

Abstract

Some studies investigated the association between the murine double minute 2 (MDM2) rs2279744 polymorphism and endometrial cancer susceptibility, but provided controversial or inconclusive results. Thus, we decided to perform this case-control study to determine the association between MDM2 rs2279744 polymorphism and endometrial cancer in a Chinese Han population. A total of 215 endometrial cancer patients and 212 cancer-free controls were included in this case-control study. We genotyped the MDM2 rs2279744 polymorphism by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). GG genotype showed a statistically significantly increased risk of developing endometrial cancer (OR=1.72, 95%CI 1.08-2.76, P=0.02). Statistically significant difference was observed when the patients and controls were compared according to G versus I (OR=1.40, 95%CI 1.07-1.84, P=0.01). A significantly higher frequency of G allele was observed in patients with stage III+IV, compared to stage I+II (OR=2.24, 95%CI 1.49-3.38, P=0.001). In conclusion, the study found that MDM2 rs2279744 polymorphism was significantly associated with endometrial cancer risk in a Chinese Han population.

Identification of key genes and pathways between type�I and type�II endometrial cancer using bioinformatics analysis

“…The MDM2 protein is overexpressed in both primary and metastatic EC, which also indicates that MDM2 protein expression is closely associated with the development of EC (50). In addition, Wu and Luo (51) revealed that the MDM2 rs2279744 polymorphism was significantly associated with EC risk in the Chinese Han population.…”