Melatonin prevents possible radiotherapy-induced thyroid injury

Arıcıgil, Mitat; Dündar, Mehmet; Yücel, Abitter; Eryılmaz, Mehmet; Aktan, Meryem; Alan, Mehmet Akif; Fındık, Sıddıka; Kılınç, İbrahim

doi:10.1080/09553002.2017.1397296

Cited by 16 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Melatonin coadministration to hyperthyroid rats significantly improved the architecture of the thyroid tissue, as shown by the presence of the majority of thyroid follicles with a regular structure and homogenous colloids. The present observations concerning melatonin are somewhat similar to those from earlier studies, which suggested that melatonin has a protective effect against thyroid gland injury (Arıcıgil et al, 2017). The histopathological analysis conducted on the thymus gland revealed that hyperthyroidism caused significant degenerative modifications, notably apoptotic lymphocytes and dispersed necrotic changes in the medullary area.…”

Section: Discussionsupporting

confidence: 91%

Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Habk,

Azab,

Ismail

et al. 2023

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

The current research aimed to evaluate the effects of L-thyroxine-induced hyperthyroidism and melatonin administration on the histopathology of the thyroid and thymus glands and Bax immunoreactivity. The rats were divided into four groups, comprising ten rats each. Rats were given the following treatments for four weeks: Group I served as the control group; Group II received melatonin; Group III received L-thyroxine; and Group IV received both L-thyroxine and melatonin. The serum levels of total T3 (tT3) and total T4 (tT4) were assessed, as well as histological examinations of the thyroid and thymus and analysis of Bax immunoexpression in both organs. The obtained results showed that in rats with hyperthyroidism, melatonin administration caused a noticeably lower level of thyroid hormones. According to the histopathological examination, hyperthyroidism induced various deteriorating changes in the thyroid and thymus glands, while melatonin therapy reduced these adverse effects. The immunohistochemical analysis demonstrated that hyperthyroid rats displayed a substantial elevation in Bax expression in the thyroid and thymus glands. However, melatonin treatment in hyperthyroid rats resulted in a marked reduction in Bax expression. Thus, it could be concluded that hyperthyroidism induced a range of degenerative changes and markedly elevated Bax expression in thyroid and thymus tissues. However, melatonin intervention ameliorated these negative effects.

show abstract

Section: Discussionsupporting

confidence: 91%

Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Habk,

Azab,

Ismail

et al. 2023

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

show abstract

“…Studies have shown that melatonin is able to neutralize different types of free radicals directly or via activation of antioxidant enzymes such as superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), and glutathione reductase (GR) (25). Several bodies of evidence have suggested that melatonin inhibits reduction/oxidation reactions following exposure to radiation, leading to inhibition of chronic oxidative stress in irradiated cells (26). A systematic review by Zetner and colleagues proposed that melatonin can be potentially used for cancer patients undergoing radiotherapy (27).…”

Section: Discussionmentioning

confidence: 99%

Radioprotective effect of a combination of melatonin and metformin on mice spermatogenesis: A histological study

Tajabadi

Javadi

Azar

et al. 2020

IJRM

View full text Add to dashboard Cite

Background: The spermatogenesis system includes highly radiosensitive cells. Hence, this system is a potential target for toxic effects of ionizing radiation during radiotherapy of abdomen and pelvis cancers, as well as after accidental radiation events. Accordingly, metformin and melatonin are two important radioprotectors that have shown an ability to prevent cell death through neutralization of free radicals and stimulating DNA damage responses. Objective: To evaluate the radioprotective effects of melatonin and metformin on mice spermatogenesis when administered alone or as a combination. Materials and Methods: In this histological Study, 40 (6-8 wk, 30 gr) NMRI mice were divided into 8 groups (n = 5/each) as control, metformin, melatonin, melatonin + metformin, radiation, radiation + melatonin, radiation + metformin, and radiation + melatonin + metformin. 37 days after the irradiation, the testicular tissues were collected for histological evaluation. Results: Single administration of melatonin could ameliorate effectively radiation toxicity in mice testis. Metformin showed radioprotective effects on some parameters such as the numbers of spermatogonia and mature sperms. Interestingly, the melatonin and metformin combination reversed the reduced number of sperms rather than single drug administration. Conclusion: The combination of melatonin with metformin can protect mice spermatogenesis against ionizing radiation more effectively compared to the single forms of these drugs. Key words: Radiation, Testis, Leydig cells, Melatonin, Metformin, Spermatogenesis.

show abstract

“…SW therapy mechanisms of various diseases have been published, including increase of anti-inflammation [ 17 , 18 , 20 , 43 , 44 ] and anti-oxidative stress [ 17 , 18 , 20 , 45 ]. The mechanisms of Mel therapy in various diseases have also been published, including increase of anti-oxidative stress [ 15 , 46 , 47 , 48 , 49 , 50 ] and anti-inflammation [ 50 , 51 , 52 , 53 ]. Based on our findings, the proposed mechanisms of Mel combined SW therapy on DN are summarized in Figure 8 .…”

Section: Discussionmentioning

confidence: 99%

Combined Melatonin and Extracorporeal Shock Wave Therapy Enhances Podocyte Protection and Ameliorates Kidney Function in a Diabetic Nephropathy Rat Model

et al. 2021

View full text Add to dashboard Cite

(1) Background: Diabetic nephropathy (DN) is common complication of diabetes. Current therapy for DN does not include promotion of podocyte protection. Therefore, we investigated the therapeutic effect of melatonin (Mel) combined extracorporeal shock wave (SW) therapy on a DN rat model. (2) Methods: The DN rats were treated with Mel (5 mg/kg) twice a week for 6 weeks and SW treatment once a week (0.13 mJ/mm2) for 6 weeks. We assessed urine microalbumin, albumin to creatinine ratio (ACR), glomerular hypertrophy, glomerular fibrosis, podocyte markers (Wilm’s tumor protein-1, synaptopodin and nephrin), cell proliferation, cell survival, cell apoptosis, renal inflammation and renal oxidative stress. (3) Results: The Mel combined SW therapy regimen significantly reduced urine microalbumin excretion (3.3 ± 0.5 mg/dL, p < 0.001), ACR (65.2 ± 8.3 mg/g, p < 0.001), glomerular hypertrophy (3.1 ± 0.1 × 106 μm3, p < 0.01) and glomerular fibrosis (0.9 ± 0.4 relative mRNA fold, p < 0.05). Moreover, the Mel combined SW therapy regimen significantly increased podocyte number (44.1 ± 5.0% area of synaptopodin, p < 0.001) in the Mel combined SW group. This is likely primarily because Mel combined with SW therapy significantly reduced renal inflammation (753 ± 46 pg/mg, p < 0.01), renal oxidative stress (0.6 ± 0.04 relative density, p < 0.05), and apoptosis (0.3 ± 0.03 relative density, p < 0.001), and also significantly increased cell proliferation (2.0 ± 0.2% area proliferating cell nuclear antigen (PCNA), p < 0.01), cell survival, and nephrin level (4.2 ± 0.4 ng/mL, p < 0.001). (4) Conclusions: Mel combined SW therapy enhances podocyte protection and ameliorates kidney function in a DN rat model. Mel combined SW therapy may serve as a novel noninvasive and effective treatment of DN.

show abstract

Melatonin prevents possible radiotherapy-induced thyroid injury

Abstract: Melatonin helped protect thyroid gland structure against the undesired cytotoxic effects of radiotherapy in rats.

Cited by 16 publications

References 25 publications

Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Radioprotective effect of a combination of melatonin and metformin on mice spermatogenesis: A histological study

Combined Melatonin and Extracorporeal Shock Wave Therapy Enhances Podocyte Protection and Ameliorates Kidney Function in a Diabetic Nephropathy Rat Model

Contact Info

Product

Resources

About