Resin glycosides evoke the Gaba release by sodium- and/or calcium-dependent mechanism

Castro-García, José Manuel; León‐Rivera, Ismael; Gutiérrez, María del Carmen

doi:10.1016/j.biopha.2017.10.089

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…The mechanic study showed that stansin 6 from I. stans reduced the degeneration pattern in the CA3 region, decreased astrocytic reactivity, and reduced the expression of IL‐1β and TNF‐α induced by kainic acid, suggesting a neuroprotective and anticonvulsant effect 121 . In addition, several resin glycosides from the I. tyrianthina were shown to evoke the GABA release by sodium‐ and/or calcium dependent mechanism 122 …”

Section: Biological Activitiesmentioning

confidence: 99%

“…121 In addition, several resin glycosides from the I. tyrianthina were shown to evoke the GABA release by sodium-and/or calcium dependent mechanism. 122…”

Section: Central Nervous System Effectsmentioning

confidence: 99%

“…3.4.13 | Pharbitic acid CThe crude resin glycoside fractions of Pharbitis nil seeds were treated with indium(III) chloride or NH 2 silica gel, and yield a series of non-macrolactone glycosidic acid methyl ester. Among them, pharesinosides A (119) and D (120), and PM-6 (121) and 7(122) were derived from pharbitic acid C 44,45. Pharesinosides A (119) possessed an Nla-Nla′ group acylated at C-3 of the Rha′ unit, while pharesinosides D (120) possess an Nla-Nla′ group acylated at C-2 of the Rha′ and an Mba group acylated at C-2 of the Rha unit.…”

mentioning

confidence: 99%

“…Pharesinosides A (119) possessed an Nla-Nla′ group acylated at C-3 of the Rha′ unit, while pharesinosides D (120) possess an Nla-Nla′ group acylated at C-2 of the Rha′ and an Mba group acylated at C-2 of the Rha unit. PM-6 (121) and 7(122) both have an Nla-Nla' group acylated at C-4 of the Rha′, and an Mba group was linked at C-2 of Rha unit in PM-6(121) and at C-3 of Rha unit in PM-7(122), respectively.…”

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confidence: 99%

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Chemistry and biological activity of resin glycosides from Convolvulaceae species

Fan

Jiang

et al. 2022

Medicinal Research Reviews

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Carbohydrate-based drug discovery has gained more and more attention during the last few decades. Resin glycoside is a kind of novel and complex glycolipids mainly distributed in plants of the family Convolvulaceae. Over the last decade, a number of natural resin glycosides and derivatives have been isolated and identified, and exhibited a broad spectrum of biological activities, such as cytotoxic, multidrug-resistant reversal on both microbial pathogens and mammalian cancer cells, antivirus, anticonvulsant, antidepressant, sedative, vasorelaxant, laxative, and α-glucosidase inhibitory effects, indicating their potential as lead compounds for drug discovery. A systematic review of the literature studies was carried out to summarize the chemistry and biological activity of resin glycosides from Convolvulaceae species, based on various data sources such as PubMed, Web of Science, Scopus, and Google scholar. The keyword "Convolvulaceae" was paired with "resin glycoside," "glycosidic acid," "glycolipid," or "oligosaccharide," and the references published between 2009 and June 2021 were covered. In this article, we comprehensively reviewed the structures of 288 natural resin glycoside and derivatives newly reported in the last decade. Moreover, we summarized the biological activities and mechanisms of action of the resin

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Section: Biological Activitiesmentioning

confidence: 99%

“…121 In addition, several resin glycosides from the I. tyrianthina were shown to evoke the GABA release by sodium-and/or calcium dependent mechanism. 122…”

Section: Central Nervous System Effectsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chemistry and biological activity of resin glycosides from Convolvulaceae species

Fan

Jiang

et al. 2022

Medicinal Research Reviews

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“…Because of the diversified structures and various bioactivities, resin glycosides have attracted plenty of interests from organic chemists and pharmacologists (Pereda-Miranda et al, 2010;Fan et al, 2022). Up to now, hundreds of resin glycosides and their derivatives have been identified and reported, some of which exhibited significant biological activities, such as cytotoxic (Fan et al, 2014;Ono et al, 2019), anti-viral (Ono et al, 2014), anticonvulsant (Castro-García et al, 2018), anti-tumor migration (Chen et al, 2017), sedative (León-Rivera et al, 2014), vasorelaxant (León-Rivera et al, 2014), and α-glucosidase inhibitory effects (Pan et al, 2015), as well as multidrug-resistant reversal effects on both microbial pathogens and mammalian cancer cells (Figueroa-González et al, 2012;Wang et al, 2018;Lira-Ricárdez and Pereda-Miranda. 2020), indicating their potential as lead compounds for drug discovery.…”

Section: Introductionmentioning

confidence: 99%

Progress in the total synthesis of resin glycosides

Wang

He³

et al. 2022

Front. Chem.

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Resin glycosides, mainly distributed in plants of the family Convolvulaceae, are a class of novel and complex glycolipids. Their structural complexity and significant biological activities have received much attention from synthetic chemists, and a number of interesting resin glycosides have been synthesized. The synthesized resin glycosides and their analogues not only helped in structural verification, structural modification, and further biological activity exploration but also provided enlightenment for the synthesis of glycoside compounds. Herein, the present review summarizes the application of various efforts toward the synthesis of resin glycosides in the last decade.

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Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model

Liu

Copmans

et al. 2019

Journal of Ethnopharmacology

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Resin glycosides evoke the Gaba release by sodium- and/or calcium-dependent mechanism

Cited by 3 publications

References 31 publications

Chemistry and biological activity of resin glycosides from Convolvulaceae species

Chemistry and biological activity of resin glycosides from Convolvulaceae species

Progress in the total synthesis of resin glycosides

Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model

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