Zinc/alogliptin combination attenuates testicular toxicity induced by doxorubicin in rats: Role of oxidative stress, apoptosis and TGF-β1/NF-κB signaling

Kabel, Ahmed M.

doi:10.1016/j.biopha.2017.10.144

Cited by 66 publications

(64 citation statements)

References 43 publications

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“…Several studies have reported that expressions of iNOS [10,49], TNFα [50], NF-κB [51] and caspase-3 [52] were increased signifi cantly in doxorubicin induced nephrotoxicity. Also, it has been reported that doxorubicin induced a signifi cant increase in the expression of TNFα, NF-κB, caspase-3 in the testes of rats [53,54]. Similar to previous studies, TNFα, NF-κB, caspase-3 and iNOS immunoreactivities were found to be signifi cantly high in testes and kidneys of rats treated with doxorubicin only in the present study.…”

Section: Discussionsupporting

confidence: 91%

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

et al. 2019

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Artemisinin, an antimalarial drug, has anticancer activity and possesses protective effects against several tissue injuries. The aim of the present study was to investigate the effects of artemisinin on doxorubicin-induced renal and testicular toxicity in rats. Doxorubicin was administered to rats at a single dose of 10 mg/kg body weight (b.w.) as a single intraperitoneal injection. Application of artemisinin was by using oral gavage feeding needle for 14 days at different specified doses (7 mg/kg and 35 mg/kg b.w.). At the end of the experiments, kidney and testis samples were collected and used for histopathological and immunohistochemical examinations. At histopathological examination, while hyperemia was the marked finding in kidney and testis of rats treated with doxorubicin only, no evidence of structural abnormalities showed in other groups. Immunohistochemical examination of the testes and kidneys demonstrated significantly increased expression of caspase-3, TNF-α, iNOS and NF-κB in rats treated with doxorubicin only. Artemisinin decreased the doxorubicin-induced overexpression of NF-κB, iNOS, TNFα and caspase-3 in these tissues of rats. Artemisinin can protect the kidney and testis against doxorubicin-induced nephrotoxicity and testotoxicity, probably through a decrease of caspase-3, TNF-α, iNOS and NF-κB expressions. It may be concluded that artemisinin has a potential for clinical use in the treatment of kidney and testis damage induced by doxorubicin. Further researches are required to determine the appropriate combination of artemisinin with doxorubicin.

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Section: Discussionsupporting

confidence: 91%

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

et al. 2019

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“…51 In present study, the results indicated that DOX induced hepatotoxicity via the expression of inammatory and apoptotic markers. 52 Evidence showed that DOX could inhibit the content of Bcl-2 in liver, and then promoted the release of cytochrome c. Moreover, cytochrome c activates the downstream apoptotic signaling like caspase-3 and leads to the apoptosis. 53 Due to our study, YQFM reduced the expression of apoptosis BAX/Bcl-2 ratio, caspase-3 and cytochrome c in damaged-liver, demonstrating the protection to DOX-induced toxicity through inhibiting the release of apoptotic proteins.…”

Section: Discussionmentioning

confidence: 99%

Yiqi Fumai lyophilized injection attenuates doxorubicin-induced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis

Jiang

et al. 2018

RSC Adv.

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“…A rich composition of polyunsaturated fatty acids in the mammalian sperm cell membrane makes the cell sensitive to free radicals. There are many experimental studies reporting that increased ROS levels decrease sperm motility and quality and increase the rate of sperm death in the semen . Using antioxidant compounds may be a useful and important strategy for preventing male infertility caused by chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…In another study, Trivedi et al suggested that hesperetin ameliorated DOX‐induced oxidative stress, DNA damage, and germ cell toxicity. Kabel reported that DOX treatment decreased the sperm count and motility while increasing the percentage of abnormal sperm and dead sperm cells and also induced apoptosis in testicular tissue. However, treatment with zinc, alogliptin, and a combination of the two attenuated these effects.…”

Section: Introductionmentioning

confidence: 99%

“…There are many experimental studies reporting that increased ROS levels decrease sperm motility and quality and increase the rate of sperm death in the semen. [15][16][17][18][19][20][21] Using antioxidant compounds may be a useful and important strategy for preventing male infertility caused by chemotherapy. Vendramini et al [9] reported that DOX treatment reduced sperm motility and concentration and increased the percentage of abnormal sperm, while amifostine treatment mitigated these parameters and reduced the damage to the seminiferous epithelium in testes of prepubertal rats.…”

Section: Introductionmentioning

confidence: 99%

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Palliative effect of curcumin on doxorubicin‐induced testicular damage in male rats

Aksu

Kandemir

Yıldırım

et al. 2019

J Biochem & Molecular Tox

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This study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)‐induced testicular damage in male rats. Thirty‐five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR‐100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR‐200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose‐dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX‐induced testicular toxicity.

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Zinc/alogliptin combination attenuates testicular toxicity induced by doxorubicin in rats: Role of oxidative stress, apoptosis and TGF-β1/NF-κB signaling

Cited by 66 publications

References 43 publications

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

Yiqi Fumai lyophilized injection attenuates doxorubicin-induced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis

Palliative effect of curcumin on doxorubicin‐induced testicular damage in male rats

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