Elevated serum creatinine and hyponatraemia as prognostic factors in canine acute pancreatitis

Marchetti, Veronica; Gori, Eleonora; Lippi, Ilaria; Luchetti, Elena; Manca, Maria Laura; Pierini, Alessio

doi:10.1111/avj.12638

Cited by 21 publications

(30 citation statements)

References 25 publications

(8 reference statements)

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“…Identification of increased creatinine as a prognostic factor in dogs with AP is in agreement with previous published studies in veterinary literature as well as in human literature . Acute kidney injury is a complication described in dogs with AP .…”

Section: Discussionsupporting

confidence: 90%

Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis

Fabrès

Dossin

Reif

et al. 2019

Veterinary Internal Medicne

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Background Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early death are still lacking. Objectives To develop a scoring system for prediction of short‐term case fatality in dogs with AP. Animals One hundred sixty‐nine dogs with AP including 138 dogs in the training cohort and 31 dogs in the validation cohort. Methods Multicenter, retrospective cohort study. Survival analysis was used to assess the associations with short‐term death (within 30 days after admission). Independent predictors of death were identified by a stepwise selection method and used for the score calculation. Results Death rate within 30 days after admission was 33% in the training cohort. Four independent risk factors for short‐term death were identified in the training cohort: presence of systemic inflammatory response syndrome, coagulation disorders, increased creatinine and ionized hypocalcemia. Canine Acute Pancreatitis Severity (CAPS) score was developed to predict short‐term death, integrating these 4 factors in a weighted way. A simplified version of CAPS score (sCAPS) including respiratory rate instead of SIRS was also assessed. The area under the receiver‐operating characteristic curve (AUC) of CAPS and sCAPS scores was 0.92 in the training cohort with an optimal cutoff of 11 (sensitivity, 89%; specificity, 90%) and 6 (sensitivity, 96%; specificity, 77%), respectively. CAPS and sCAPS score were validated in the validation cohort with respective AUC of 0.91 and 0.96. Conclusions and Clinical Importance We propose 2 scoring systems that allow early and accurate prediction of short‐term death in dogs with AP.

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Section: Discussionsupporting

confidence: 90%

Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis

Fabrès

Dossin

Reif

et al. 2019

Veterinary Internal Medicne

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“…Azotaemia has been a constant negative prognostic marker in several recent studies of AP in dogs and cats 22 35. AP and AKI have a two-way relationship, as the former can be the cause of the latter, and vice versa 18 36. Furthermore, herein, AKI was significantly associated with death, in corroboration with recent findings 18.…”

Section: Discussionsupporting

confidence: 89%

Prognostic markers and assessment of a previously published clinical severity index in 109 hospitalised dogs with acute presentation of pancreatitis

et al. 2020

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BackgroundAcute pancreatitis (AP) is common in dogs. Nevertheless, validated clinical severity index (CSI) scoring systems to assess severity and guide treatment in current, large-scale studies are unavailable.MethodsThis is a retrospective study including 109 dogs. Pancreatitis was diagnosed based on clinical signs, abdominal sonographic evidence, positive pancreatic lipase assays and experts’ assessment consensus.ResultsThe survival rate was 75 per cent (82 dogs). Azotaemia and presence of local complications (ie, ascites) and secondary complications (ie, acute kidney injury and acute respiratory distress syndrome) were significantly associated with death. In agreement with the previously published CSI, respiratory anomalies were significantly associated with death. However, in disagreement with that study, high scores in the kidney and local abdominal complication categories and the sum of scores of all nine categories, but not high gastrointestinal category score, were also significantly associated with death. A final CSI score of at least 4 was associated with death.ConclusionsThis study has validated a nine-category CSI, proven a useful assessment tool in dogs with AP. Several previously reported and novel prognostic markers were assessed.

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“…Our study has identified elevated creatinine level could be as the prognostic factor for canine pancreatitis at initial presentation when the patients were first visiting between survival and non-survival groups. The result of creatinine level in this study was similar as previous published study (Marchetti et al, 2017;Sato et al, 2017). However, there were different findings of prognostic factors compared to previous study.…”

Section: Discussionsupporting

confidence: 87%

The Effect of Routine Therapy Alone and Combined with Hyperbaric Oxygen Treatment on Prognostic Factors in Dogs with Acute Pancreatitis

IJu¹,

TienHuan²,

HseinChi³

et al. 2019

PVJ

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The aim of this study was to evaluate the effect of supportive treatment combined with hyperbaric oxygen (HBO) therapy in dogs with acute pancreatitis by prognostic factors. Dogs entering the trial were randomly assigned to receive only regular supportive therapy (control group) or combined hyperbaric oxygen therapy with symptomatic and supportive therapy (HBOT group). The regular supportive measurements consisted of intravenous fluid, analgesia, antibiotics, antiemetics, gastric acid suppression, nutritional management, and so on. If the patient had diabetes mellitus, hyperglycemia was controlled by insulin. The dogs of the HBOT group were conducted in hyperbaric animal chamber (PAHI-A, Pan-America Hyperbarics Inc., R.O.C.) and HBO therapy involved 90 min of 100% oxygen treatment at a pressure of 2.5 ATA, once to twice daily for a total of 3 to 5 sessions. There were significant findings regarding to specific canine pancreatic lipase immunoreactivity (Spec cPL) and C-reactive protein (CRP) in the survivors, but no significant differences were found in the non-survivors. The down trend of sequential CRP concentration was noticed in HBOT group. The level of creatinine may be as an important criterion when the patients with AP were first visit clinic. The prognostic factors such as CRP, Spec cPL had a good response to routine combined with HBOT in survivors group. Likewise, the level of Spec cPL was decreased significantly after treatment no matter routine or routine combined with HBOT in survivors group. HBOT combined with symptomatic and routine treatment might improve systemic inflammation probably in canine acute pancreatitis. In survivors group the creatinine levels was significant lower than that in non-survivors group. Therefore, the levels of creatinine can be as prognostic factor in dogs with acute pancreatitis.To Cite This Article: Ho IJ, Hsu TH, Wang HC, Chen KS and Lee WM, 2019. The effect of routine therapy alone and combined with hyperbaric oxygen treatment on prognostic factors in dogs with acute pancreatitis. Pak Vet J, 39(4): 505-510. http://dx.

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Elevated serum creatinine and hyponatraemia as prognostic factors in canine acute pancreatitis

Abstract: In dogs with AP, hyponatraemia and azotaemia seem to be significantly associated with an increased risk of death.

Cited by 21 publications

References 25 publications

Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis

Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis

Prognostic markers and assessment of a previously published clinical severity index in 109 hospitalised dogs with acute presentation of pancreatitis

The Effect of Routine Therapy Alone and Combined with Hyperbaric Oxygen Treatment on Prognostic Factors in Dogs with Acute Pancreatitis

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