Psychotropic in the environment: risperidone residues affect the behavior of fish larvae

Kalichak, Fabiana; Idalêncio, Renan; Rosa, João Gabriel Santos da; Barcellos, Heloísa Helena de Alcântara; Fagundes, Michele; Piato, Ângelo; Barcellos, Leonardo José Gil

doi:10.1038/s41598-017-14575-7

Cited by 26 publications

(4 citation statements)

References 46 publications

(63 reference statements)

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“…Behavioral alterations are responses that came from internal (physiological) and external (environmental) interactions. The zebrafish ( Danio rerio ) is a social specie, that needs to interact with its conspecifics 38 . These findings in our study show the deleterious interaction of the Al in social behavior an important biomarker even for species perpetuation as well as for physiological and neural normal function.…”

Section: Discussionmentioning

confidence: 99%

Cannabis sativa-based oils against aluminum-induced neurotoxicity

Alves

Tamagno

Vanin

et al. 2023

Sci Rep

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The use of terpenoid compounds in different neural-related conditions is becoming useful for several illnesses. Another possible activity of these compounds is the reduction of nervous impairment. Cannabis sativa plants are known for their concentration of two important terpenoids, the delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD and THC have central peripheral activities already described and their usage in different brain diseases, such as Alzheimer's and multiple sclerosis. Aluminum (Al) is known as an important neurotoxic compound, the physiological action of Al is not known already, and in high concentrations can lead to intoxication and cause neurotoxicity. Here we evaluated the potential effect of two different doses of CBD- and THC-rich based oils against Al-induced toxicity, in the zebrafish model. We evaluated behavioral biomarkers of the novel tank test (NTT) and social preference test (SPT), and biochemical markers: the activity of the enzyme acetylcholinesterase (AChE) and the antioxidant enzymes—catalase, superoxide dismutase, and glutathione-S-transferase. CBD- and THC-based oils were able to increase the AChE activity helping the cholinergic nervous system actuate against Al toxicity which was reflected by the behavioral biomarkers changes. We concluded that the oils have a protective effect and might be used with proposals for neurological and antioxidant impairment avoidance caused by Al intoxications.

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Section: Discussionmentioning

confidence: 99%

Cannabis sativa-based oils against aluminum-induced neurotoxicity

Alves

Tamagno

Vanin

et al. 2023

Sci Rep

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“…Organs such as the gonads are usually affected, and extremely high concentrations of estrogenic endocrine disrupting pharmaceuticals have been detected in them and other organs of aquatic animals (Gibson et al 2005; Langston 2020; Pironti et al 2021). Similarly, antipsychotic and mood modifying drugs, such as risperidone, clozapine, olanzapine, ziprasidone, carbamazepine, chlorpromazine, and haloperidol, have been reported in aquatic environments, where they affect the behavior and disrupt normal functioning of aquatic life even at low concentrations (Kalichak et al 2017; Ford and Herrera 2019; Patel et al 2019; Adeola et al 2022). Haloperidol is a tranquilizing antipsychotic drug used for treating symptoms of schizophrenia, one of the most common mental diseases that affects over 20 million people globally, as well as for treating schizoaffective disorder, bipolar disorder, acute anxiety, severe depression, and autism (Anderson et al 1989; López‐García et al 2017; Trawiński and Skibiński 2017; Rahman and Marwaha 2022).…”

Section: Introductionmentioning

confidence: 99%

Effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus

Chiejina,

Ikeh,

Enebe

et al. 2023

J Aqua Anim Hlth

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Haloperidol is an antipsychotic and neuroleptic drug for treatment of symptoms of schizophrenia and other neuroleptic conditions. The study investigated the effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile Clarias gariepinus. Clarias gariepinus juveniles were exposed to different concentrations of haloperidol (0.12, 0.24 and 0.48 mg/L) for 15 days and subsequently withdrawn from the drug for 5 days. Blood samples from the fishes on days 1, 5, 10, 15 and on the 5‐day withdrawal periods were analysed for mutagenic changes, after which the fish were sacrificed. The brain was sampled for serotonergic and dopaminergic analyses. There was formation of micronuclei in the peripheral fish blood which increased as the duration and concentrations of the drug increased. The drug significantly reduced the serotonin activity but increased dopamine activity. Some of the studied parameters, however, recovered from the effects of the drug after the 5‐day withdrawal period. Haloperidol is toxic to fish and its use in the environment should be guarded to avoid adverse impacts on non‐target species like fish.

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“…Antipyretic drugs cause acute toxicity only at high concentrations, whereas sub-lethal effects at low, environmentally relevant concentrations (adverse effects at molecular, biochemical and cellular levels) ( Parolini, 2020 ). Antiepileptic and antipyretic drugs at low concentration also affect living organisms by acting on the specific biochemical pathways that are evolutionarily conserved ( Martin-Diaz et al, 2009 ; Kalichak et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

End-of-life management strategies of pharmaceuticals in Portuguese households

Veiga

Sousa

Sousa³

et al. 2022

Waste Manag Res

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The end of life of pharmaceutical products through environmentally unsafe routes is a growing concern in our society. However, the studies reported so far, apart from being limited in number, do not reflect the current management practices for the end-of-life management of pharmaceuticals. Published work lacks an in-depth analysis in focusing on the pharmaceutical waste in households. The present work focused on (1) performing a state-of-the art overview to compare worldwide studies and the results and (2) implementing a comprehensive survey in Portugal ( n = 454 respondents). The results showed that the delivery to pharmacies was used by the majority of the respondents (72%), indicating a good awareness of pharmaceutical waste management issues, when compared to the reviewed studies. Statistically significant variables for the destination of end-of-use pharmaceuticals include gender, age and distance from the residence to the pharmacy ( p < 0.05). Most participants believe that educating the population on existing structures of medication and packaging management is of the utmost importance to improve the national managing system. This is the first study conducted in Portugal; it includes statistical analysis of the data and reflects on the practices that should be adopted to reduce incorrect pharmaceutical waste disposal. These findings call upon the strategies to strengthen the pharmaceutical waste management programme.

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Psychotropic in the environment: risperidone residues affect the behavior of fish larvae

Cited by 26 publications

References 46 publications

Cannabis sativa-based oils against aluminum-induced neurotoxicity

Cannabis sativa-based oils against aluminum-induced neurotoxicity

Effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus

End-of-life management strategies of pharmaceuticals in Portuguese households

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