Breastfeeding During Infancy Is Associated With a Lower Future Risk of Pediatric Multiple Sclerosis

Brenton, J. Nicholas; Engel, Casey; Sohn, Min-Woong; Goldman, Myla D.

doi:10.1016/j.pediatrneurol.2017.09.007

Cited by 28 publications

(21 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 While this study did not demonstrate an association of infant breastfeeding and risk of MS, a separate study showed that a lack of infant breastfeeding was associated with an increased risk for a future diagnosis of MS (odds ratio: 4.43). 24…”

Section: Birth Factorsmentioning

confidence: 99%

Multiple Sclerosis in Children: Current and Emerging Concepts

et al. 2020

Self Cite

View full text Add to dashboard Cite

Multiple sclerosis is being increasingly recognized and diagnosed in children. In the past several years, advances have been made in diagnosing multiple sclerosis in children, identifying new genetic and environmental risk factors, delineating underlying immunobiology, characterizing imaging findings, and implementing new treatment strategies. In this review, we discuss these advances. Future research into the determinants of multiple sclerosis in children and into new treatment options will be aided by continued international collaboration.

show abstract

Section: Birth Factorsmentioning

confidence: 99%

Multiple Sclerosis in Children: Current and Emerging Concepts

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…[14][15][16][17] After stratification by sex, a strong association was found among men but not among women in both Norwegian and Italian cohorts. 17 Absence of infant breastfeeding has also been associated with increased risk of pediatriconset MS. 18 Using two large population-based case-control studies, we investigated the influence of breastfeeding on subsequent MS risk among women and men, considering a large number of covariates and potential confounding factors including number of siblings, adolescent BMI, smoking and HLA-DRB1*15:01 status.…”

Section: Introductionmentioning

confidence: 99%

“…14–17 After stratification by sex, a strong association was found among men but not among women in both Norwegian and Italian cohorts. 17 Absence of infant breastfeeding has also been associated with increased risk of pediatric-onset MS. 18…”

Section: Introductionmentioning

confidence: 99%

Breastfeeding is associated with reduced risk of multiple sclerosis in males, predominantly among HLA-DRB1*15:01 carriers

Hedström

Adams²,

Shao³

et al. 2020

Multiple Sclerosis Journal - Experimental, Translational and Cl

View full text Add to dashboard Cite

Background Breastfeeding as an infant appears protective against later development of some autoimmune diseases, but research into its influence on multiple sclerosis (MS) risk has yielded inconclusive results. Objective We investigated the possible impact of breastfeeding on MS risk. Methods We used two population-based case–control studies comprising 3670 cases and 6737 matched controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between MS and exposure to prolonged breastfeeding (4 months or longer) versus reduced breastfeeding (less than 4 months). A meta-analysis of case–control studies that assessed the impact of breastfeeding on MS risk among women and men was conducted. Results Prolonged breastfeeding was associated with reduced MS risk among men (OR 0.7, 95% CI 0.5–0.9) but not among women (OR 0.9, 95% CI 0.8–1.1). Among men, a synergistic effect was observed between HLA-DRB1*15:01 carrier status and reduced breastfeeding. Conclusions Findings from the current study add to accumulating evidence that breastfeeding may be a modifiable protective factor for reducing the risk of MS in offspring. When possible, mothers should be supported to breastfeed their infants; however, the mechanism of a sex-specific biologic effect of breastfeeding on MS risk is unclear.

show abstract

“…The association between breastfeeding and MS has also been investigated in a few studies, in which prolonged breastfeeding has shown a protective effect. 14,15 The incidence of MS has amplified quickly worldwide. 16,17 In particular, this increase has affected the countries of the Arabian Gulf.…”

mentioning

confidence: 99%

Risk factors of multiple sclerosis in Aseer region, Kingdom of Saudi Arabia A case-control study

Siddiqui

Alsabaani

Abouelyazid

et al. 2021

NSJ

View full text Add to dashboard Cite

To investigate socio-demographic and environmental risk factors of multiple sclerosis (MS) in Aseer region, Kingdom of Saudi Arabia (KSA). Methods:This was a retrospective, record, and interview based matched case control study completed in the neurology clinics at tertiary hospitals in Aseer, KSA. It included 82 MS cases and 82 controls. The study used a structured questionnaire to collect information on key socio-demographic and environmental exposures. The main outcome measure Original Articles was a statistically significant relationship of key sociodemographic and environmental risk factors with MS.Results: A total of 82 registered patients, 50 were females, resulting in a female to male ratio of 1.56:1. Various risk factors were found to have a statistically significant association with MS which included female (OR=3.01, 95% CI ]1.59:5.69[; p<0.001), family history of MS (OR=2.1, 95%CI ]2.4:1.7[ p=0.04), low exposure to sunlight (OR=2.02, 95%CI ]2.53: 9.9[ p<0.001), only fed breast milk in childhood (OR=0.46, 95%CI ]0.55:0.39[; p<0.001), parental consanguinity (OR=2.17 95%CI ]4.11:1.14[ p=0.017), history of chickenpox (OR=15.59 95% CI ]68.7:3.55[; p<0.01). On using multiple logistic regression, chicken pox infection (AOR=0.045, 95%CI ]0.015-0.135[; p=0.001)and low sun-exposure (AOR=.271, 95%CI ].121-.609[; p<0.05) were deduced as the predictors of MS in this region. Conclusion: This study offers unique insights into the risk factors of MS. Low sun exposure and childhood chickenpox are significantly related to the development of MS in the Aseer region.

show abstract

Breastfeeding During Infancy Is Associated With a Lower Future Risk of Pediatric Multiple Sclerosis

Cited by 28 publications

References 35 publications

Multiple Sclerosis in Children: Current and Emerging Concepts

Multiple Sclerosis in Children: Current and Emerging Concepts

Breastfeeding is associated with reduced risk of multiple sclerosis in males, predominantly among HLA-DRB1*15:01 carriers

Risk factors of multiple sclerosis in Aseer region, Kingdom of Saudi Arabia A case-control study

Contact Info

Product

Resources

About