Measurement and scan reproducibility of parameters of intravoxel incoherent motion in renal tumor and normal renal parenchyma: a preliminary research at 3.0 T MR

Pan, Jingjing; Zhang, Hongtao; Man, Fengyuan; Shen, Yanguang; Wang, Yingwei; Zhong, Yan; Ma, Lu; Wang, Haiyi; Ye, Huiyi

doi:10.1007/s00261-017-1361-7

Cited by 24 publications

(17 citation statements)

References 33 publications

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“…We found D = 2.30 ± 0.16 × 10 −3 mm 2 /s and 2.36 ± 0.14 × 10 −3 mm 2 /s, and f = 19.4 ± 1.9% and 29.6 ± 2.3% for the left and right kidneys, respectively. These values are within the range of reported literature values in healthy volunteers of D = 1.4‐2.1 × 10 −3 mm 2 /s and f = 9‐33% . Recently, a T 2 ‐dependence of D was reported in prostate cancer patients, which could point to our long echo times as a possible explanation why our D‐values lay at the edges of the interval of reported literature values.…”

Section: Discussionsupporting

confidence: 89%

“…The wCV of D for FC‐IVIM was similar to literature values of conventional IVIM ( wCV D = 5‐17%). The wCV of v and τ from FC‐IVIM are in a similar range as D* from conventional IVIM model (e.g., 25‐194 for various abdominal organs).…”

Section: Discussionsupporting

confidence: 84%

“…We find that f is estimated at high precision, particularly for the liver (intersession wCV = 14.7%) and kidneys (intersession wCV = 14.8‐17.8%) when compared with literature (liver: 11.4‐34% median 25.3; kidney: 25‐36%). The wCV of D for FC‐IVIM was similar to literature values of conventional IVIM ( wCV D = 5‐17%). The wCV of v and τ from FC‐IVIM are in a similar range as D* from conventional IVIM model (e.g., 25‐194 for various abdominal organs).…”

Section: Discussionmentioning

confidence: 68%

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Optimal acquisition scheme for flow‐compensated intravoxel incoherent motion diffusion‐weighted imaging in the abdomen: An accurate and precise clinically feasible protocol

Gurney‐Champion

Rauh

Harrington

et al. 2019

Magnetic Resonance in Med

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Purpose: Flow-compensated (FC) diffusion-weighted MRI (DWI) for intravoxel-incoherent motion (IVIM) modeling allows for a more detailed description of tissue microvasculature than conventional IVIM. The long acquisition time of current FC-IVIM protocols, however, has prohibited clinical application. Therefore, we developed an optimized abdominal FC-IVIM acquisition with a clinically feasible scan time. Methods: Precision and accuracy of the FC-IVIM parameters were assessed by fitting the FC-IVIM model to signal decay curves, simulated for different acquisition schemes. Diffusion-weighted acquisitions were added subsequently to the protocol, where we chose the combination of b-value, diffusion time and gradient profile (FC or bipolar) that resulted in the largest improvement to its accuracy and precision. The resulting two optimized FC-IVIM protocols with 25 and 50 acquisitions (FC-IVIM opt25 and FC-IVIM opt50 ), together with a complementary acquisition consisting of 50 diffusion-weighting (FC-IVIM comp ), were acquired in repeated abdominal free-breathing FC-IVIM imaging of seven healthy volunteers. Intersession and intrasession within-subject coefficient of variation of the FC-IVIM parameters were compared for the liver, spleen, and kidneys. Results: Simulations showed that the performance of FC-IVIM improved in tissue with larger perfusion fraction and signal-to-noise ratio. The scan time of the FC-IVIM opt25 and FC-IVIM opt50 protocols were 8 and 16 min. The best in vivo performance was seen in FC-IVIM opt50 . The intersession within-subject coefficients of variation of FC-IVIM opt50 were 11.6%, 16.3%, 65.5%, and 36.0% for FC-IVIM model parameters diffusivity, perfusion fraction, characteristic time and blood flow velocity, respectively. Conclusions: We have optimized the FC-IVIM protocol, allowing for clinically feasible scan times (8-16 min).

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 68%

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Optimal acquisition scheme for flow‐compensated intravoxel incoherent motion diffusion‐weighted imaging in the abdomen: An accurate and precise clinically feasible protocol

Gurney‐Champion

Rauh

Harrington

et al. 2019

Magnetic Resonance in Med

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“…Furthermore, as reported previously, some parameters, such as D∗, might not be reliable enough for clinical translation. [23,24] Therefore, it might be of potential benefit to also predict MVD with a more reliable and clinical routinely used DWI protocol with only 2 b-values. Some previous studies indicated that also ADC values may predict MVD.…”

Section: Discussionmentioning

confidence: 99%

Whole-lesion ADC histogram analysis is not able to reflect microvessel density in HNSCC

Meyer¹,

Hamerla²,

Leifels³

et al. 2019

Medicine

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Diffusion-weighted imaging (DWI) is a functional imaging technique sensitive to microstructure in tissues. It is widely acknowledged to reflect cellularity in tumors. A small part of DWI is also sensitive to perfusion-related information and might therefore be also be able to reflect microvessel density in tumor tissues. Aim of the present study was to elucidate possible correlations between microvessel density and apparent diffusion coefficient (ADC) values in head and neck squamous cell carcinoma (HNSCC). Thirty-four patients with histologically proven primary HNSCC were included in the study. DWI was performed with a 3 T magnetic resonance imaging (MRI) (b-values 0 and 800 s/mm 2 ) and histogram analysis was calculated with a whole lesion measurement. In every case, microvessel density was estimated with CD105-stained specimens. There were no statistically significant correlations between ADC histogram parameters and microvessel density. The calculated correlation coefficients ranged from r = -0.27, P = .13 for entropy and vessel area to r = 0.16, P = .40 for ADCmin and vessel count. Whole-lesion histogram analysis of ADC values cannot reflect microvessel density in HNSCC.

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“…Intravoxel incoherent motion parameters (especially D * ) have modest repeatability and reproducibility (Table 2), [121][122][123][124][125][126][127][128][129][130] perhaps due to their inherent inflexibility in the standard IVIM model and sensitivity to noise, 6 and several approaches have been explored to improve their uncertainty. IVIM values are dependent on the acquisition parameters such as b-values, 118 131 and fitting methods, 81 and uniform acquisition of IVIM data and development of robust IVIM fitting are warranted.…”

Section: Challengesmentioning

confidence: 99%

Perfusion-driven Intravoxel Incoherent Motion (IVIM) MRI in Oncology: Applications, Challenges, and Future Trends

Iima

2021

MRMS

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Recent developments in MR hardware and software have allowed a surge of interest in intravoxel incoherent motion (IVIM) MRI in oncology. Beyond diffusion-weighted imaging (and the standard apparent diffusion coefficient mapping most commonly used clinically), IVIM provides information on tissue microcirculation without the need for contrast agents. In oncology, perfusion-driven IVIM MRI has already shown its potential for the differential diagnosis of malignant and benign tumors, as well as for detecting prognostic biomarkers and treatment monitoring. Current developments in IVIM data processing, and its use as a method of scanning patients who cannot receive contrast agents, are expected to increase further utilization. This paper reviews the current applications, challenges, and future trends of perfusion-driven IVIM in oncology.

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Measurement and scan reproducibility of parameters of intravoxel incoherent motion in renal tumor and normal renal parenchyma: a preliminary research at 3.0 T MR

Abstract: Excellent reproducibility evaluation for ADC and D, good for f, and poor for D* derived from IVIM was performed in renal tumors, normal renal cortex, and medulla. D* has limited reliability and scan-rescan reproducibility should be improved.

Cited by 24 publications

References 33 publications

Optimal acquisition scheme for flow‐compensated intravoxel incoherent motion diffusion‐weighted imaging in the abdomen: An accurate and precise clinically feasible protocol

Optimal acquisition scheme for flow‐compensated intravoxel incoherent motion diffusion‐weighted imaging in the abdomen: An accurate and precise clinically feasible protocol

Whole-lesion ADC histogram analysis is not able to reflect microvessel density in HNSCC

Perfusion-driven Intravoxel Incoherent Motion (IVIM) MRI in Oncology: Applications, Challenges, and Future Trends

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