“…The role of YAP/TAZ in cardiomyogenesis was first revealed by studies on fetal heart development. Fetal cardiomyocytes undergo extensive proliferation that ends abruptly after birth, and these changes are strongly correlated with YAP activation and deactivation, respectively ( Del Re et al, 2013 ; Xin et al, 2013 ; Lin et al, 2014 , 2015 ; Mosqueira et al, 2014 ; Cho et al, 2017 ; Estarás et al, 2017 ; Hou et al, 2017 ; Khalafalla et al, 2017 ; Mills et al, 2017 ; Mochizuki et al, 2017 ; Ragni et al, 2017 ; Artap et al, 2018 ; Wang X. et al, 2018 ; Ito et al, 2019 ; Torrini et al, 2019 ). Postnatal heart tissue growth is driven primarily by cardiomyocyte hypertrophy (increase in cell size and deposition of extracellular matrix), rather than increase in cell number ( von Gise et al, 2012 ; Xin et al, 2013 ; Artap et al, 2018 ).…”