Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology

Tarantino, Umberto; Iolascon, Giovanni; Cianferotti, Luisella; Masi, Laura; Marcucci, Gemma; Giusti, Francesca; Marini, Francesca; Parri, Simone; Feola, Maurizio; Rao, Cecilia; Piccirilli, Eleonora; Zanetti, Emanuela Basilici; Cittadini, Noemi; Alvaro, Rosaria; Moretti, Antimo; Calafiore, Dario; Toro, Giuseppe; Gimigliano, Francesca; Resmini, Giuseppina; Brandi, Maria Luisa

doi:10.1007/s10195-017-0474-7

Cited by 157 publications

(160 citation statements)

References 173 publications

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“…This probably indicates the severity of bone loss during the acute phase of SCI. Raised BTMs indicate rapid bone loss and are currently used for individual fracture risk assessment in postmenopausal females and for monitoring osteoporosis treatment, but they are not yet used in high risk groups such as SCI patients [18,19]. Acute SCI presents with a state of spinal shock, resulting in sublesional flaccid muscle tone.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury

et al. 2020

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To evaluate bone turnover markers (BTMs) in individuals with acute spinal cord injury (SCI) and to compare the results with those of healthy controls and postmenopausal females. Overview of Literature: SCI significantly impacts bone health. Change in bone mineral density appears 6 months after SCI and rapid bone loss during the acute phase is often underestimated, resulting in osteoporosis and a high risk of sublesional fractures. However, few studies have evaluated BTMs in the Indian SCI population. Despite a high risk of fracture, there are no guidelines for the diagnosis, monitoring, and management of SCI-induced osteoporosis. Methods: Twenty patients within 1 month of traumatic SCI who had been admitted to a tertiary care rehabilitation center were included in this study. Serum BTMs, C telopeptide (CTX) as a bone resorption marker, and osteocalcin as a bone formation marker, were serially measured at baseline, and 3 and 6 months after SCI. BTMs of SCI patients were compared with those of a control group of age-matched healthy males, premenopausal females, and a vulnerable group of postmenopausal females. Results: BTMs were significantly elevated in patients with SCI, with maximum levels observed at the 3rd month of injury. At baseline, the bone resorption marker CTX was approximately 3 times higher in SCI patients than in the control male population and premenopausal females, and about double that of postmenopausal females. The rise in the bone formation marker was marginal in comparison to that of the bone resorption marker. BTMs were persistently elevated and did not reach the normative range until the 6th month of SCI. Conclusions: Raised bone resorption markers in comparison to bone formation markers indicate hyper-resorption-related bone loss following acute SCI. Markedly elevated bone resorption markers in the SCI population, compared with those in control and vulnerable groups, emphasize the need for early bone health monitoring and management.

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Section: Discussionmentioning

confidence: 99%

Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury

et al. 2020

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“…Hence, this metabolic bone disease is inevitably linked with aging. To be more specific, the prevalence of osteoporosis is currently increasing worldwide probably due to the expansion of the elderly population, along with the prolongation of life expectancy [11][12][13][14] . The underlying mechanism of the precedent correlation includes sex hormones and blood nutrients deficiency, as well as, the accumulation of Reactive Oxygen Species (ROS) 3 .…”

Section: Jrpmsmentioning

confidence: 99%

Could treating periodontitis prevent osteoporosis? An update of the last decade

Skoufou¹,

Yavropoulou²,

Zafeiris³

2019

JRPMS

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Periodontitis has often been reported as a systematic disease independently associated with a range of AbstractChronic periodontitis and osteoporosis are both systemic diseases, characterized by bone resorption. Over the last decade, their correlation has been examined closely, mainly to investigate whether they present a risk factor or an indicator for each other. It is their pathogenetic similarities, their numerous common risk factors and their frequent concomitant development that initiated researchers' interest in the precise association between these two maladies. The present review is aiming to analyse this correlation, laying emphasis on the effects of periodontal status on the skeletal bone mineral density, as suggested by the latest studies. It will also attempt to clarify whether periodontal management could influence the progression or the onset of osteoporosis.

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“…Bone metabolism occurs continuously, balanced between growth and bone resorption 16,18 . Bone metabolism activity is known by examination of bone turnover markers (BTM) [16][17][18] . BTM is a biomarker of bone formation or osteoblastic activity and biomarkers of bone resorption or osteoclastogenesis [16][17][18] .…”

Section: Differences Of Serum Calcium and Ctx Levels Between Control mentioning

confidence: 99%

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2019

IJPSR

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The aim of this study was to (1) analyze the effect of fresh goat's milk intervention on serum Carboxyterminal Cross-Linked Telopeptide of type I Collagen (CTX) and calcium in untrained healthy women, therefore goat milk can be used for osteoporosis therapy, (2) examined the relationship between levels of calcium and CTX after the intervention of fresh goat's milk. The research design was a controlled randomized trial. Eighteen volunteers sedentary women were randomized into 2 equal groups (control, n=9, and trial, n=9), aged 18-19 years, healthy, and did not consume high calcium foods or drugs. The treatment group was treated with 250 ml/day of fresh goat's milk, given in the morning, for 110 days. Fasting morning serum calcium and CTX levels were measured before and after fresh goat milk intervention. The data were analyzed by the statistical t-test and linear correlation with the significance level of 5%. Untreated, both serum calcium and CTX levels in the trial and control group were not significantly different (p>0.05). Treated, serum calcium levels were higher (p<0.05) in the trial group than the control group. Serum CTX levels were lower (p<0.05) in the trial group than in the control group. There was a significant increase in calcium levels and the significant decrease of CTX levels after-treated in the trial group. Goat milk affects inhibiting the process of bone resorption in untrained healthy women.

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Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology

Cited by 157 publications

References 173 publications

Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury

Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury

Could treating periodontitis prevent osteoporosis? An update of the last decade

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