Errata: Do Implantable Cardioverter Defibrillators Reduce Mortality in Patients With Chronic Kidney Disease at All Stages? An Updated Meta-Analysis

Abstract

The errors in the following list appeared in the article titled "Do Implantable Cardioverter Defibrillators Reduce Mortality in Patients With Chronic Kidney Disease at All Stages?: An Updated Meta-Analysis" by Linghua Fu, Qiongqiong Zhou, Wengen Zhu, Lin Huang, Ying Ding, Yang Shen, Jinzhu Hu, and Kui Hong (Vol. 58, No. 3, 371-7, 2017).

Do Implantable Cardioverter-Defibrillators Prevent Sudden Cardiac Death in End-Stage Renal Disease Patients on Dialysis?

“…Following the adjustment for age and various covariates, the link between CKD and overall mortality disappeared, which implies that patients with a history of VT/VF are at high risk and CKD status does not further increase the risk [49]. Based on data from 11 studies and 20,196 CKD patients, Fu et al [19] demonstrated that implantation of ICDs for primary (7 studies) and secondary (4 studies) prevention decreased all-cause mortality in stage 3 CKD patients compared with patients without an ICD device (aHR = 0.71; 95% CI, 0.61 to 0.82). Such a survival benefit was not observed in stage 4 or stage 5 CKD patients.…”

“…ICD insertion for primary prevention was more effective in averting fatal events than insertion for secondary prevention in this nonrandomised study. In the opinion of Fu et al [19], a high rate of post-implantation complications, including device-related infections and non-cardiac-related deaths, may negatively impact the survival benefit associated with ICD implantation [19]. In turn, the data from the National Inpatient Sample (NIS) collected in the years 2016-2019 demonstrated that the risk of mortality was not increased in dialysis patients following the implantation of ICDs [67].…”

“…This group of patients was found to show diminished heart rate response to subcutaneous nerve activity and conduction system diseases. In CKD, rapid worsening of sympathetic tone precedes atrioventricular block, VA, and sudden death [19,20]. Left ventricular hypertrophy (LVH), which is a common finding in patients on dialysis, also enhances the risk of SCD [21].…”

ICD for Patients With Severe Renal Dysfunction

“…In this current issue of International Heart Journal, Fu, et al have summarized clinical trials investigating the efficacy of ICD among patients in all stages of chronic kidney disease (CKD). 5) They demonstrated that patients with CKD stage 3 would benefit from treatments with ICD implantation compared with those with CKD stage 3 not receiving treatments with ICDs, whereas there was no significant improvement in all-cause mortality in patients with CKD stages 4 or 5. The most novel point in their study was the analysis of the efficacy of ICD based on a detailed classification of each stage of CKD.…”

Update on Hemodialysis-Induced Multiorgan Ischemia

“…Common assumptions concerning the etiology of cardiac sudden death and heart failure are often developed on the basis of patients without kidney failure or the need for dialysis and, therefore, may not apply to patients on hemodialysis in general. 5 In addition, the risk/benefit considerations of pharmacologic 6 and device-based interventions 7–9 are different in the hemodialysis population. Efficacy is usually lower/absent, and treatment-related adverse events are much more common.…”