Evidence of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake in Taiwanese pregnant women and the health effects on birth outcomes

Tsai, Yu-Chen; Tsai, Ming‐Song; Hou, Jia‐Woei; Lin, Ching-Ling; Chen, Chih-Yao; Chang, Ching Chih; Liao, Kai-Wei; Wang, Shu Li; Chen, Bai-Hsiun; Wu, Ming Tsang; Hsieh, Chia‐Jung; Chen, Mei-Lien

doi:10.1016/j.scitotenv.2017.07.175

Cited by 35 publications

(12 citation statements)

References 59 publications

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“…There were substantial evidence that prenatal phthalate exposure results in abnormal fetal development and adverse perinatal outcome, even persisted in childhood. Those studies, examining the phthalate metabolites in maternal urine samples, maternal meconium or cord blood, reported inverse (82,84,85,(89)(90)(91)(92)(93)(94)(95)(96)(97)(98), null (68,72,79,83,99), and positive (85,97) associations between women exposed to phthalates and its fetal growth. Moreover, a few longitudinal studies (97,(100)(101)(102)(103)(104)(105)(106)(107) had assessed associations of certain phthalate exposure during pregnancy and BMI, waist circumference, and risk of overweight/obesity in childhood, and the findings were inconsistent and often sexspecific ( Table 4).…”

Section: Prenatal Phthalate Exposure and Growth Of Fetal And Childmentioning

confidence: 99%

“…HMWPm with BMI z-scores in boys HMWPm with BMI z-scores in girls (53) MiBP, MBzP, MEHP and MECPP with BMI trajectories in males MECPP with BMI trajectories in female (107) factor expression in mice (108). Most epidemiological studies in humans found that exposure to LMWP metabolites, such as MEP, MBP, MiBP, and HMWP metabolites, MEHHP, and MEOHP, were negatively related to birth weight (82,85,(89)(90)(91)(92)(93)(94)(95)(96), birth length (89,91,95), and circumferences of head, chest or abdominal (84,85,91,94,96,98). In nested case-control studies, Zhang et al found that in utero phthalate metabolite exposure (DBP in cord blood and MEHP in meconium) and maternal urinary phthalate levels (such as MMP, MBP, MEHP, MEOHP, and MEHHP) were negatively correlated with birth weight (89,90).…”

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

“…And they, however, did fail to find the relationships between DEHP and its metabolite exposure during pregnancy and fetal growth or birth outcomes. Tsai et al (98) found maternal phthalate (MMP, MEP, MiBP, and MnBP) exposure during the first trimester were unrelated to fetal growth, but exposure during the second or third trimester would affect fetal birth height and HC. Besides, several epidemiological studies also failed to find associations of phthalate metabolite exposure during pregnancy with any of birth outcomes among their newborns from Japan (83), France (99), and Italy (68).…”

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

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The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. This article aims to review the endocrine impairment and potential outcomes of prenatal phthalate exposure. Prenatal exposure phthalates would disrupt the levels of thyroid, sex hormone, and 25-hydroxyvitamin D in pregnant women or offspring, which results in preterm birth, preeclampsia, maternal glucose disorders, infant cryptorchidism, infant hypospadias, and shorter anogenital distance in newborns, as well as growth restriction not only in infants but also in early adolescence and childhood. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

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Section: Prenatal Phthalate Exposure and Growth Of Fetal And Childmentioning

confidence: 99%

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

See 1 more Smart Citation

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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“…Previous studies have found that phthalates can penetrate the placenta and may affect the fetus [16]. Exposure to phthalates in utero may have adverse health effects on children, including poor birth outcomes [17], impaired neurodevelopment, and behavioral syndromes in childhood [2,18,19]. Therefore, considerable attention should be paid to phthalate exposure in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Distribution and Dietary Predictors of Urinary Phthalate Metabolites among Pregnant Women in Shanghai, China

Zang

Liao

et al. 2019

IJERPH

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The exposure of pregnant women to phthalates is a major concern due to their adverse effect on developmental outcomes. Diet is an important pathway for exposure to phthalate compounds. Nevertheless, studies on dietary exposure of pregnant women to phthalates in China are limited. We aimed to assess the distribution and dietary predictors of phthalate exposure among pregnant women in China. We measured the levels of 10 urinary phthalate metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry in 210 pregnant women as part of the 2015 China National Chronic Disease and Nutrition Survey in Shanghai. We assessed the urinary specific gravity-adjusted phthalate metabolite levels along with potential demographic and dietary predictors. Multivariable linear regression analysis was used to examine the relationship between each potential demographic variable and dietary predictor and urinary phthalate metabolites. Seven urinary phthalate metabolites were detected in >95% of pregnant women. The geometric mean (GM) of urinary phthalate biomarker values were highest for monobutyl phthalate (GM: 25.29 ng/mL) and monoisobutyl phthalate (GM:11.18 ng/mL). Multivariate regression analysis indicated that a lower educational level was associated with elevated urinary phthalate metabolite levels. Edible seaweed consumption had a positive correlation with urinary monoethyl phthalate and monoisobutyl phthalate levels, and the total molar sum of Di-(2-ethylhexyl) phthalate metabolites. These findings offer important data on the dietary exposure to phthalates in pregnant Chinese women and suggest interventions to improve food safety.

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“…Several epidemiological studies reported that DEHP exposure affects pregnant women and birth outcomes [6][7][8]. Specifically, women at the 75th percentile of DEHP metabolite concentrations have a longer gestational period than women at the 25th percentile [7].…”

Section: Introductionmentioning

confidence: 99%

Subacute Exposure to an Environmentally Relevant Dose of Di-(2-ethylhexyl) Phthalate during Gestation Alters the Cecal Microbiome, but Not Pregnancy Outcomes in Mice

Bashir

Gao

Gutiérrez

et al. 2021

Toxics

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Di-2-ethylhexyl phthalate (DEHP) is a plasticizer commonly found in polyvinyl chloride, medical equipment, and food packaging. DEHP has been shown to target the reproductive system and alter the gut microbiome in humans and experimental animals. However, very little is known about the impact of DEHP-induced microbiome changes and its effects during pregnancy. Thus, the objective of this study was to investigate the effects of DEHP exposure during pregnancy on the cecal microbiome and pregnancy outcomes. Specifically, this study tested the hypothesis that subacute exposure to DEHP during pregnancy alters the cecal microbiome in pregnant mice, leading to changes in birth outcomes. To test this hypothesis, pregnant dams were orally exposed to corn oil vehicle or 20 µg/kg/day DEHP for 10 days and euthanized 21 days after their last dose. Cecal contents were collected for 16S Illumina and shotgun metagenomic sequencing. Fertility studies were also conducted to examine whether DEHP exposure impacted birth outcomes. Subacute exposure to environmentally relevant doses of DEHP in pregnant dams significantly increased alpha diversity and significantly altered beta diversity. Furthermore, DEHP exposure during pregnancy significantly increased the relative abundance of Bacteroidetes and decreased the relative abundance of Firmicutes and Deferribacteres compared with controls. The affected taxonomic families included Deferribacteraceae, Lachnospiraceae, and Mucisprillum. In addition to changes in the gut microbiota, DEHP exposure significantly altered 14 functional pathways compared with the control. Finally, DEHP exposure did not significantly impact the fertility and birth outcomes compared with the control. Collectively, these data indicate that DEHP exposure during pregnancy shifts the cecal microbiome, but the shifts do not impact fertility and birth outcomes.

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Evidence of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake in Taiwanese pregnant women and the health effects on birth outcomes

Cited by 35 publications

References 59 publications

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Distribution and Dietary Predictors of Urinary Phthalate Metabolites among Pregnant Women in Shanghai, China

Subacute Exposure to an Environmentally Relevant Dose of Di-(2-ethylhexyl) Phthalate during Gestation Alters the Cecal Microbiome, but Not Pregnancy Outcomes in Mice

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