Differential modulatory effects of cocaine on marmoset monkey recognition memory

Melamed, Jonathan; Jesus, Fernando M. de; Aquino, Jéssica; Vannuchi, Clarissa R S; Duarte, Renata B.; Maior, Rafael S.; Tomaz, Carlos; Barros, Marília

doi:10.1016/bs.pbr.2017.07.005

Cited by 7 publications

(3 citation statements)

References 104 publications

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“…The performance of marmoset monkeys was evaluated in the recognition memory task after acute and repeated exposure to cocaine (5 mg/kg, i.p) for seven consecutive days. Acute administration of cocaine improved the marmoset's recognition memory, whereas it had a detrimental effect after repeated exposure [208]. Thus, depending on the cocaine administration schedule, opposite effects on spatial recognition memory can occur, with prolonged exposure associated with cognitive impairment.…”

Section: Preclinical Studiesmentioning

confidence: 95%

Cognitive Alterations in Addictive Disorders: A Translational Approach

et al. 2023

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The cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be irreversible, even after the end of drug abuse consumption. Improving our understanding of the molecular and cellular alterations associated with cognitive decline could be essential to developing specific therapeutic strategies for its treatment. Developing animal models to simulate drug abuse-induced learning and memory alterations is critical to continue exploring this clinical situation. The main aim of this review is to summarize the most recent evidence on cognitive impairment and the associated biological markers in patients addicted to some of the most consumed drugs of abuse and in animal models simulating this clinical situation. The available information suggests the need to develop more studies to further explore the molecular alterations associated with cognitive impairment, with the ultimate goal of developing new potential therapeutic strategies.

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Section: Preclinical Studiesmentioning

confidence: 95%

Cognitive Alterations in Addictive Disorders: A Translational Approach

et al. 2023

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“…In other words, cocaine imposed different effects upon cognitive function according to different administration schedule and affect different brain regions. For instance, cocaine has been proved to improve the marmosets' recognition memory when given acutely post sample, whereas it had a detrimental effect after the repeated exposure [114]. Another related research found that cocaine-naïve monkeys performed better in stimulus discrimination and reversal task compared to monkeys who had previously self-administered cocaine [115].…”

Section: Cocainementioning

confidence: 99%

Mechanism of psychoactive substance-induced cognitive disorders: does tau protein play a role?

Wang¹,

Lv²,

He³

et al. 2022

Front. Biosci. (Landmark Ed)

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Psychoactive substances are a class of chemical substances which could cause public health threats. Cognitive disorders are a category of mental health disorders that primarily affect cognitive abilities. Tau protein could maintain neuronal cytoskeleton stabilization. Post-translational modification of tau, especially phosphorylation, is an important way to regulate the structure and function of tau and phosphorylated tau is closely related to cognitive function. Lots of studies have reported the phenomenon that psychoactive substances can cause cognitive function impairment. We reviewed recent related studies and discussed them by drug classification. We mainly focused on cognitive disorders caused by acute or chronic exposure of each drugs, animal experiments and the mechanisms associated with tau phosphorylation, then compared the similarities and differences among them, trying to find out the common rules. The results suggested that tau phosphorylation is involved in psychoactive substance-induced cognitive disorder and different psychoactive substances may act by affecting amount or activity of different kinases and phosphatases in the metabolic pathway of tau. We demonstrated that tau protein is a potential target for psychoactive substances induced cognitive disorder treatments.

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“…A discrimination index was calculated for the test trial to establish object recognition memory: novel object exploration time-familiar object exploration time/exploration time of both objects. A single 1.5-mL blood sample was taken from each subject 1 week before the behavioral trial, following the procedure described previously [35,36].…”

Section: Behavioral Test In Non-human Primatesmentioning

confidence: 99%

Neutral ceramidase is a marker for cognitive performance in rats and monkeys

et al. 2020

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Background Ceramides are lipid molecules determining cell integrity and intercellular signaling, and thus, involved in the pathogenesis of several psychiatric and neurodegenerative disorders. However, little is known about the role of particular enzymes of the ceramide metabolism in the mechanisms of normal behavioral plasticity. Here, we studied the contribution of neutral ceramidase (NC), one of the main enzymes mediating ceramide degradation, in the mechanisms of learning and memory in rats and non-human primates. Methods Naïve Wistar rats and black tufted-ear marmosets (Callithrix penicillata) were tested in several tests for short- and long-term memory and then divided into groups with various memory performance. The activities of NC and acid ceramidase (AC) were measured in these animals. Additionally, anxiety and depression-like behavior and brain levels of monoamines were assessed in the rats. Results We observed a predictive role of NC activity in the blood serum for superior performance of long-term object memory tasks in both species. A brain area analysis suggested that high NC activity in the ventral mesencephalon (VM) predicts better short-term memory performance in rats. High NC activity in the VM was also associated with worse long-term object memory, which might be mediated by an enhanced depression-like state and a monoaminergic imbalance. Conclusions Altogether, these data suggest a role for NC in short- and long-term memory of various mammalian species. Serum activity of NC may possess a predictive role in the assessing the performance of certain types of memory.

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Differential modulatory effects of cocaine on marmoset monkey recognition memory

Cited by 7 publications

References 104 publications

Cognitive Alterations in Addictive Disorders: A Translational Approach

Cognitive Alterations in Addictive Disorders: A Translational Approach

Mechanism of psychoactive substance-induced cognitive disorders: does tau protein play a role?

Neutral ceramidase is a marker for cognitive performance in rats and monkeys

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