Effect of dietary supplementation of nitrocompounds on Salmonella colonization and ileal immune gene expression in laying hens challenged with Salmonella Enteritidis

Adhikari, Pratima; Cosby, D. E.; Cox, N. A.; Kim, W K

doi:10.3382/ps/pex221

Cited by 10 publications

(7 citation statements)

References 36 publications

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“…The LD 50 of NP for broiler chicken might be above 1,300 mg/kg ( Jung et al., 2004b ), which is higher than the dosages tested in the present study. Previous studies reported that adding 100-ppm NP in broiler diet did not cause negative outcomes on laying hens or Eimeria -challenged broilers ( Adhikari et al., 2017 ; Teng et al., 2020a ). However, it should be noted that high doses of NP (150 or 200 ppm) decreased BW, BWG, and FI of broiler chickens.…”

Section: Discussionmentioning

confidence: 93%

“…Nitro-compounds could act as methane inhibitors and decreased 94% of methane production in ruminal fluid ( Anderson et al., 2003 ). Furthermore, NP exhibited microbial inhibitory effects on broiler chickens and laying hens by reducing Salmonella typhimurium in the intestine, as well as upregulated immune responses against pathogens invasion ( Jung et al., 2004b ; Adhikari et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

et al. 2020

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A 2 × 3 factorial arrangement study was conducted to evaluate 3 dosages of 2-nitro-1-propanol ( NP ; 0, 150, and 200 ppm) on intestinal health of birds with or without Eimeria challenge. A total of 432 thirteen-day-old male broiler chickens were randomly allocated to 6 treatments with 8 replicate cages of 9 birds per cage. All birds were fed with treatment diets from day 13 to 21. Birds in the challenge groups were gavaged with Eimeria maxima (50,000 oocysts per bird), Eimeria tenella (50,000 oocysts per bird), and Eimeria acervulina (250,000 oocysts per bird) on day 15. Growth performance was evaluated from day 13 to 21, and gut permeability was measured by fluorescein isothiocyanate dextran on day 20. The intestinal lesion, intestinal morphology, and oocysts shedding were determined at the end of the trial. The linear and quadratic orthogonal polynomial contrasts were used to evaluate the effects of increasing NP doses in responses to Eimeria challenge. The results showed that NP was not able to maintain efficient growth performance but improved gut leakage during Eimeria infection period. On the other hand, Eimeria infection increased gut permeability ( P < 0.0001) and reduced ileal digestible energy ( IDE ) and apparent ileal digestibility ( AID ) of nitrogen. However, the increase of NP linearly enhanced IDE and AID of nitrogen ( P < 0.01). Moreover, an interaction between challenge and linear dosage effects was observed for IDE ( P = 0.0066) and AID of nitrogen ( P = 0.0462). The results indicated that NP improved nutrient digestibility and reduced total oocysts shedding in birds challenged with Eimeria spp. Besides, higher NP doses numerically improved villi height in the intestine. In summary, NP was not able to maintain growth performance of birds but presented positive outcomes on nutrient digestibility and reduced oocysts shedding during mixed Eimeria infection.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

et al. 2020

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“…Salmonella invasion of intestinal tissues. Gastrointestinal tissue colonization and faecal shedding in chickens experimentally exposed to S. Enteritidis are higher in food-deprived than in well-fed chickens (Holt, Lara, Moore, & Gast, 2006; (Adhikari et al, 2018;Adhikari, Cosby, Cox, & Kim, 2017;Rattanawut, Todsadee, & Yamauchi, 2017). Also, Lactobacillus plantarum given as a probiotic to chicks has proven successful in reducing Salmonella colonization mediated by colon-induced intestinal barrier disruption through regulating expression of tight junction genes and inflammatory responses (Wang et al, 2018).…”

Section: The Physiological Condition Of Birds Including Starvation mentioning

confidence: 99%

“…Enteritidis‐infected chickens fed on finely milled diets mixed with whole wheat grains cleared bacteria from caecal contents and liver at a higher rate and had lower cloacal swab recovery than chickens fed with fine or coarse ground feeds under experimental conditions (Ratert, Sander, Verspohl, Beyerbach, & Kamphues, ). Inclusion of various chemical additives in poultry feeds reduces Salmonella in gastrointestinal tract and extra‐gastrointestinal organ colonization and faecal shedding in chickens (Adhikari et al, ; Adhikari, Cosby, Cox, & Kim, ; Rattanawut, Todsadee, & Yamauchi, ). Also, Lactobacillus plantarum given as a probiotic to chicks has proven successful in reducing Salmonella colonization mediated by colon‐induced intestinal barrier disruption through regulating expression of tight junction genes and inflammatory responses (Wang et al, ).…”

Section: Salmonella Colonization and Shedding In Birdsmentioning

confidence: 99%

Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review

Rukambile

Sintchenko

Muscatello

et al. 2019

Zoonoses and Public Health

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Livestock meat and offal contribute significantly to human nutrition as sources of high‐quality protein and micronutrients. Livestock products are increasingly in demand, particularly in low‐ and middle‐income settings where economies are growing and meat is increasingly seen as an affordable and desirable food item. Demand is also driving intensification of livestock keeping and processing. An unintended consequence of intensification is increased exposure to zoonotic agents, and a contemporary emerging problem is infection with Campylobacter and Salmonella spp. from livestock (avian and mammalian), which can lead to disease, malabsorption and undernutrition through acute and chronic diarrhoea. This can occur at the farm, in households or through the food chain. Direct infection occurs when handling livestock and through bacteria shed into the environment, on food preparation surfaces or around the house and surroundings. This manuscript critically reviews Campylobacter and Salmonella infections in animals, examines the factors affecting colonization and faecal shedding of bacteria of these two genera as well as risk factors for human acquisition of the infection from infected animals or environment and analyses priority areas for preventive actions with a focus on resource‐poor settings.

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“…Although differential gene expression (DGE) in chickens in response to infection with SE was the focus of a number of recent studies [65][66][67], it is relevant to conduct an in-depth examination of the effects of infection on a complex of characteristics, including profiles of the cecal microbiome and regulation of the genes involved in immunity, transport, and metabolism. It is also important to conduct further investigations on the dynamics of shifts in the blood biochemical/immunological parameters and, from a practical perspective, on testing the phytobiotics such as Intebio ® for improving the immune response and performance.…”

Section: Introductionmentioning

confidence: 99%

Effects of Essential Oils-Based Supplement and Salmonella Infection on Gene Expression, Blood Parameters, Cecal Microbiome, and Egg Production in Laying Hens

Laptev¹,

Yildirim²,

Ilina³

et al. 2021

Animals

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One of the main roles in poultry resistance to infections caused by Salmonella is attributed to host immunity and intestinal microbiota. We conducted an experiment that involved challenging Lohmann White laying hens with Salmonella Enteritidis (SE), feeding them a diet supplemented with an EOs-based phytobiotic Intebio®. At 1 and 7 days post-inoculation, the expression profiles of eight genes related to immunity, transport of nutrients in the intestine, and metabolism were examined. Cecal microbiome composition and blood biochemical/immunological indices were also explored and egg production traits recorded. As a result, the SE challenge of laying hens and Intebio® administration had either a suppressive or activating effect on the expression level of the studied genes (e.g., IL6 and BPIFB3), the latter echoing mammalian/human tissue-specific expression. There were also effects of the pathogen challenge and phytobiotic intake on the cecal microbiome profiles and blood biochemical/immunological parameters, including those reflecting the activity of the birds’ immune systems (e.g., serum bactericidal activity, β-lysine content, and immunoglobulin levels). Significant differences between control and experimental subgroups in egg performance traits (i.e., egg weight/number/mass) were also found. The phytobiotic administration suggested a positive effect on the welfare and productivity of poultry.

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Effect of dietary supplementation of nitrocompounds on Salmonella colonization and ileal immune gene expression in laying hens challenged with Salmonella Enteritidis

Cited by 10 publications

References 36 publications

2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review

Effects of Essential Oils-Based Supplement and Salmonella Infection on Gene Expression, Blood Parameters, Cecal Microbiome, and Egg Production in Laying Hens

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