Correlations Among Ultrasound‐Guided Diffuse Optical Tomography, Microvessel Density, and Breast Cancer Prognosis

Niu, Sihua; Zhu, Qingli; Jiang, Yuxin; Zhu, Jiaan; Xiao, Mengsu; You, Shengyong; Wei-xun, Zhou; Xiao, Yu

doi:10.1002/jum.14416

Cited by 8 publications

(3 citation statements)

References 32 publications

(76 reference statements)

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“…A great body of evidence supports a positive correlation between microvascular density, tumor grade, and aggressiveness [1,2,3]. Indeed, in breast carcinoma and other neoplasias, the incidence of metastatic disease increases with the number of microvessels in the tumor mass [4], highlighting the importance to develop therapeutic strategies targeting angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts

García-Quiroz

Garcı́a-Becerra

Santos-Cuevas

et al. 2019

Cancers

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Calcitriol is a multitarget anticancer hormone; however, its effects on angiogenesis remain contradictory. Herein, we tested whether the antiangiogenic phytochemicals curcumin or resveratrol improved calcitriol antitumorigenic effects in vivo. Triple-negative breast cancer tumoral cells (MBCDF-T) were xenografted in nude mice, maintaining treatments for 3 weeks. Tumor onset, volume and microvessel density were significantly reduced in mice coadministered with calcitriol and curcumin (Cal+Cur). Vessel count was also reduced in mice simultaneously treated with calcitriol and resveratrol (Cal+Rsv). Cal+Cur and Cal+Rsv treatments resulted in less tumor activated endothelium, as demonstrated by decreased tumor uptake of integrin-targeted biosensors in vivo. The renal gene expression of Cyp24a1 and Cyp27b1 suggested increased calcitriol bioactivity in the combined regimens. In vitro, the phytochemicals inhibited both MBCDF-T and endothelial cells proliferation, while potentiated calcitriol’s ability to reduce MBCDF-T cell-growth and endothelial cells migration. Resveratrol induced endothelial cell death, as deduced by increased sub-G1 cells accumulation, explaining the reduced tumor vessel number in resveratrol-treated mice, which further diminished when combined with calcitriol. In conclusion, the concomitant administration of calcitriol with curcumin or resveratrol synergistically promoted anticancer effects in vitro and in vivo in human mammary tumor cells. Whereas the results suggest different mechanisms of action of the phytochemicals when coadministered with calcitriol, the converging biological effect was inhibition of tumor neoangiogenesis.

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Section: Introductionmentioning

confidence: 99%

Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts

García-Quiroz

Garcı́a-Becerra

Santos-Cuevas

et al. 2019

Cancers

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show abstract

“…The work [95] was devoted to the study of the possible interconnection between the data acquired with the help of US-controlled DOS and the concentration level of hypoxia-induced factor (HIF-1α) and CD34 in confirmed breast cancer. Immunohistochemical examination of HIF-1α and CD34 revealed differences in the total hemoglobin concentration and microvessel density between the HIF-1α positive and negative groups.…”

Section: Diffuse Optical Spectroscopymentioning

confidence: 99%

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

Бесчастнов¹,

Ryabkov²,

Pavlenko³

et al. 2018

Sovrem Tehnol Med

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The problem of studying the oxygen status and biotissue microcirculation is of special interest for many directions in medical science since one of the causes of hypoxia development as a typical pathophysiological process is a microcirculatory "failure" associated with the impairment of normal anatomy of the capillary wall, changes in the rheological blood properties, acceleration or slowdown of the blood flow. Current imaging techniques enable the researchers to study the processes of biosystem vital activity at various levels: from organs and tissues to the substance molecular composition. Methods of functional bioimaging implemented into clinical practice provide the opportunity of watching online the processes of substance movement in the body, monitoring blood flow parameters, assessing hypoxia level, characterizing metabolism in greater detail, and, at the same time, correcting timely pathological conditions. The main advantages and disadvantages of bioimaging examination methods such as BOLD functional magnetic resonance tomography, positron emission tomography, optical imaging, laser Doppler flowmetry, and transcutaneous oximetry are considered in the present review. Special attention is paid to diffuse optical spectroscopy as a noninvasive method of lifetime study of substance content in biotissues. The principle of diffuse optical spectroscopy is based on the ability of tissue chromophores (oxyhemoglobin, deoxyhemoglobin, fatty acids, collagen) to absorb diffusely scattered light of a definite wavelength. Their concentrations are calculated with the allowance for the absorption coefficients of chromophores. Diffuse optical spectroscopy is being introduced in clinical practice to diagnose the degree of tumor malignization, evaluate vascularization in reconstructive operations, diagnose hypoxic tissue conditions, monitor intraoperatively blood flow parameters, measure hypoxia levels in diabetes mellitus. It provides the possibility to define and make clear indications to skin plastic surgery and, conceivably, to develop new methods of skin plasty.

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“…Niu S et al [25] reported that microvessel density of breast cancer and total hemoglobin (HBT) were linearly correlated. The total Hb concentration can reflect a tumor's blood supply.…”

Section: Diffuse Optical Tomographmentioning

confidence: 99%

Sonographic Features of Triple Negative Breast Cancer

Li¹,

Wang²,

Ding³

et al. 2018

Advanced Ultrasound in Diagnosis and Therapy

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Correlations Among Ultrasound‐Guided Diffuse Optical Tomography, Microvessel Density, and Breast Cancer Prognosis

Cited by 8 publications

References 32 publications

Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts

Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

Sonographic Features of Triple Negative Breast Cancer

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