Resilience to stress and risk of gastrointestinal infections

Melinder, Carren; Hiyoshi, Ayako; Kasiga, Teresa; Halfvarson, Jonas; Fall, Katja; Montgomery, Scott

doi:10.1093/eurpub/ckx179

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…This has the potential to establish and/or exacerbate children’s perception of the link between stress (child and caregiver) and food consumption, manifesting as problematic eating patterns, such as food fussiness and low food enjoyment [ 9 ]. Through brain-gut neurohormonal mechanisms, psychological stress has been shown to increase intestinal permeability [ 8 ]. For this reason psychosocial stress has been identified as a risk factor for development of functional GI disorders [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Stress may manifest in GI somatic symptomology, eating and nutrition dysregulation, and underlying pathophysiological dysfunction that may lead to clinical GI disorders [ 5 , 6 , 7 , 8 , 9 ]. Though evidence suggests a close relationship between psychosocial stress and GI conditions, unexplained food reactions in general, and as potentially related to stress, remain understudied.…”

Section: Introductionmentioning

confidence: 99%

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The Role of the Mind-Body Connection in Children with Food Reactions and Identified Adversity: Implications for Integrating Stress Management and Resilience Strategies in Clinical Practice

et al. 2023

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Child adversity is often associated with poor quality of life in pediatric gastrointestinal disorders, including non-allergic food reactions (food intolerances), which may be improved using mind-body interventions. We conducted an observational study to (1) describe child adversity (stressors) and resilience factors in children with food intolerances, and (2) explore the association between stressors and self-reported use of integrative modalities. A retrospective chart review of children ≥4-years-old presenting to a pediatric food intolerances clinic from 2017 to 2020 was performed (n = 130). Use of integrative medicine at intake, demographic, illness, and social history data were collected. Qualitative analysis identified exposure to stressors and resilience strategies. Correlation was assessed using a chi-square test. Management of the medical condition was the most common stressor, indicating impact on quality of life. Resilience strategies included themes of self-coping and social support. Individuals with one or more stressors were more likely to be using an integrative modality (most commonly, mind-body interventions) prior to their visit (X2 = 8.1, p = 0.004). Our hypothesis-generating study suggests that screening for child adversity and integrative medicine use may be used to better address quality of life and personalized approaches to treat pediatric food intolerances.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of the Mind-Body Connection in Children with Food Reactions and Identified Adversity: Implications for Integrating Stress Management and Resilience Strategies in Clinical Practice

et al. 2023

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“…Nevertheless, there was either inverse or no association of stress with enteric infections (Melinder et al, 2017).…”

mentioning

confidence: 95%

Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections

Riba

Olier

Lacroix‐Lamandé

et al. 2018

Brain, Behavior, and Immunity

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Neonatal period is characterized by an immature intestinal barrier. Scattered evidence suggests that early life stressful events induce long lasting alterations of intestinal homeostasis mimicking Irritable Bowel Syndrome (IBS). Those observations highlighting defect of intestinal barrier by early life stress questioned its potential role as a risk factor for gastrointestinal disorders such as colitis and infections. In this study, we aimed to analyze if maternal separation (MS) in mice mimicks IBS main features. We next addressed whether MS could trigger or exacerbate colitis in genetically predisposed mice and/or enhance susceptibility to gastrointestinal infections in wild type mice. MS induced main features of IBS in adult wild type male mice i.e. intestinal hyperpermeability, visceral hypersensitivity, microbiota dysbiosis, bile acid malabsorption and low grade inflammation in intestine associated with a defect of Paneth cells and the ILC3 population. This breach in mucosal barrier functions in adults was associated with a systemic IgG response against commensal E. coli and increased IFNγ secretion by splenocytes. However, in IL10 mice, MS did not trigger nor worsen colitis. Furthermore, wild type mice submitted to MS did not show increase susceptibility to gastrointestinal infections (S. Typhimurium, L. monocytogenes or T. gondii) compared to controls. Altogether, our results identify MS in mice as a good experimental model for IBS mimicking all the main features. In addition, early life stress, even though it has long lasting consequences on intestinal homeostasis, does not constitute a facilitating factor to colitis in predisposed individuals nor to gastrointestinal infections in wild type mice.

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mentioning

confidence: 99%

“…5,6 Due to a well-investigated relation between stress and the immune system, refugee children are particularly prone to severe infections. 6,7 Moreover, Ukrainian children have low vaccine coverage for routine immunizations, including those against viral infections. 8,9 The war-induced largest-scale displacement of children in Europe since World War II coincided with substantial increases in seasonal viruses' circulation observed at the advanced stage of coronavirus disease 2019 (COVID-19) pandemic.…”

mentioning

confidence: 99%

Ukrainian War Refugee Children With Particularly Severe Viral Infections: A Case Series Report

Pluta,

Karny,

Lipińska

et al. 2023

Pediatric Infectious Disease Journal

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The humanitarian crisis in Ukraine in 2022 led to a massive migration of refugees to Poland. Immigrant children, living in overcrowded humanitarian hubs, were exposed to multiple stressful factors likely affecting their immune systems. This case series study aimed to describe a particularly severe course of common viral infections, in Ukrainian refugee children. We present 2 case series of Ukrainian refugee children: 5 hospitalized due to either adenovirus (AdV) and 8 with rotavirus (RV) infection, admitted within 3 months in each case series, recruited retrospectively. Most patients lived in humanitarian hubs and were neglected on admission (dehydrated, with poor hygiene and anxious). All RV infection cases had symptoms of severe gastroenteritis requiring intravenous rehydration. Metabolic acidosis was present in 6 children, and hypoglycemia in 4 participants. None of them were vaccinated against RV. All children with AdV infection had prolonged fever, dyspnea requiring oxygen therapy and hyperinflammation. In 2 AdV infection cases with no clinical improvement and increasing inflammatory markers, intravenous immunoglobulins and glucocorticosteroids were used. The combination of stressful factors and living in overcrowded hubs during the high prevalence of viral infections led to a particularly severe course of viral infections in Ukrainian refugee children.

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Resilience to stress and risk of gastrointestinal infections

Abstract: Lower stress resilience in adolescence is associated with reduced risk of gastrointestinal infections in adulthood, rather than the hypothesized increased risk.

Cited by 5 publications

References 33 publications

The Role of the Mind-Body Connection in Children with Food Reactions and Identified Adversity: Implications for Integrating Stress Management and Resilience Strategies in Clinical Practice

The Role of the Mind-Body Connection in Children with Food Reactions and Identified Adversity: Implications for Integrating Stress Management and Resilience Strategies in Clinical Practice

Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections

Ukrainian War Refugee Children With Particularly Severe Viral Infections: A Case Series Report

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