Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Mariño, Eliana; Richards, James L.; McLeod, Keiran H.; Stanley, Dragana; Yap, Yu Anne; Knight, Jacinta; McKenzie, Craig; Kranich, Jan; Oliveira, Ana Carolina; Rossello, Fernando; Krishnamurthy, Balachander; Nefzger, Christian M.; Macia, Laurence; Thorburn, Alison N.; Baxter, Alan G.; Morahan, Grant; Wong, Lee H.; Polo, José M.; Moore, Robert J.; Lockett, Trevor; Clarke, Julie; Topping, David L.; Harrison, Leonard C.; Mackay, Charles R.

doi:10.1038/ni1117-1271c

Cited by 17 publications

(13 citation statements)

References 1 publication

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“…Butyrate also plays an essential role in modulating the immune response by inducing differentiation of regulatory T cells (Tregs), particularly Fox3p+ Tregs, and inhibiting inflammatory cytokines, such as IFN-γ (26,246,(250)(251)(252)(253). Interestingly, when NOD mice were fed a diet designed to increase acetate and butyrate levels they experienced a decrease in T1D incidence when compared to controls (254).…”

Section: Gut Metabolomementioning

confidence: 99%

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

et al. 2020

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Section: Gut Metabolomementioning

confidence: 99%

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

et al. 2020

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“…SCFAs have a number of potential roles in modulating metabolic health [19]. Acetate is most productive acid among SCFAs and appears to stimulate leptin secretion in adipocytes, involving energy balance and appetite, [16] conditioning immune cell in response to protect against T2D [55] and regulating blood pressure. [56,57] And the impaired acetate production might be associated with weight gain in midlife.…”

Section: Discussionmentioning

confidence: 99%

Age-related Changes of Microbiota in Midlife Associated with Reduced Saccharolytic Potential: An In Vitro Study

Zhu

Chen

et al. 2020

Preprint

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Background: Gut microbiota diversity and abundance are critical in maintaining human health, and subject to significantly reduce in seniors. Gut microbiota are reported to be stable across the long adulthood in general, but lack of careful examination, especially for the midlife people.Results: To characterize the gut microbiota in midlife, we investigated the faecal microbiota between two groups of healthy people, young, 20-39 years old, n=15; and midlife, 40-60 years old, n=15. Metabolic responses of the microbiota were studied through in vitro batch fermentation model. Despite no difference was observed in the diversity indies between the two age groups, a wide range taxonomic changes were found in the faecal microbiota. Furthermore, substantial Bifidobacterium reduction was also found in both faecal and fermented samples. The level of SCFAs in both faecal and starch fermented samples is similar in both groups. However, when fermentation was performed with inulin as the sole carbon source, the acetate concentration and inulin degradation rate decreased while the gas production increased in midlife group, suggesting a deficiency of saccharolytic potential in midlife, especially for non-digestible carbohydrate. Conclusions: Our data demonstrate that gut microbiota begin to change as early as in midlife. The reduction in Bifidobacterium dominates the change of the microbiota composition in midlife resulting in attenuated saccharolytic capability of inulin, leading to insufficient acetate production which might be associated with healthy problems in this transition period from young to elderly.

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“…The figures were drawn using the freely available Servier Medical Art Resource (https://smart.servier.com/). and products influence the pancreatic immune environment and confer protection against T1D (86)(87)(88). In humans, T1D status has been associated with an increase in Bacteroides and Bacteroidetes-to-Firmicutes ratio (67, 89-91), and with a dearth of Bifidobacterium species (67, 90).…”

Section: Fut2 T1d and Microbial Composition And Metabolitesmentioning

confidence: 99%

Can the FUT2 Non-secretor Phenotype Associated With Gut Microbiota Increase the Children Susceptibility for Type 1 Diabetes? A Mini Review

et al. 2020

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The global toll of type 1 diabetes (T1D) has steadily increased over the last decades. It is now widely acknowledged that T1D pathophysiology is more complex than expected. Indeed, a multifaceted interplay between genetic, metabolic, inflammatory and environmental factors exists that leads to heterogeneous clinical manifestations across individuals. Children with non-secretor phenotype and those affected by T1D share low abundance of bifidobacteria, low content of short-chain fatty acids, intestinal phosphatase alkaline and a high incidence of inflammatory bowel diseases. In this context, host-gut microbiota dyad may represent a relevant contributor to T1D development and progression due to its crucial role in shaping host immunity and susceptibility to autoimmune conditions. The FUT2 gene is responsible for the composition and functional properties of glycans in mucosal tissues and bodily secretions, including human milk. FUT2 polymorphisms may profoundly influence gut microbiota composition and host susceptibility to viral infections and chronic inflammatory disease. In this minireview, the possible interplay between mothers' phenotype, host FUT2 genetic background and gut microbiota composition will be discussed in perspective of the T1D onset. The study of FUT2-gut microbiota interaction may add a new piece on the puzzling T1D etiology and unveil novel targets of intervention to contrast T1D development and progression. Dietary interventions, including the intake of α-(1, 2)-fucosyl oligosaccharides in formula milk and the use of specific prebiotics and probiotics, could be hypothesized.

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Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Cited by 17 publications

References 1 publication

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

Age-related Changes of Microbiota in Midlife Associated with Reduced Saccharolytic Potential: An In Vitro Study

Can the FUT2 Non-secretor Phenotype Associated With Gut Microbiota Increase the Children Susceptibility for Type 1 Diabetes? A Mini Review

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