Complete genome sequence of a novel avian paramyxovirus isolated from wild birds in South Korea

Jeong, Junhui; Kim, Young‐Sik; An, Injung; Wang, Seung-Jun; Kim, Yongkwan; Lee, Hyun-Jeong; Choi, Kang-Seuk; Im, Se-Pyeong; Min, Wongi; Oem, Jae-Ku; Jheong, Weon-Hwa

doi:10.1007/s00705-017-3588-6

Cited by 24 publications

(17 citation statements)

References 12 publications

(23 reference statements)

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“…Wild birds harbor a huge diversity of avian avulaviruses (AAvV), formally designated avian paramyxoviruses (1). There are currently 19 species, corresponding to avian paramyxoviruses 1 to 13, in addition to 6 novel species proposed since 2017 which have recently been ratified by the ICTV (2–5). These viruses are nonsegmented, single stranded, and have a negative-sense RNA genome which is approximately 15 kb long and contains six genes (6).…”

Section: Introductionmentioning

confidence: 99%

Antarctic Penguins as Reservoirs of Diversity for Avian Avulaviruses

Wille

Aban

Wang

et al. 2019

J Virol

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Wild birds harbor a huge diversity of avian avulaviruses (formerly avian paramyxoviruses). Antarctic penguin species have been screened for avian avulaviruses since the 1980s and, as such, are known hosts of these viruses. In this study, we screened three penguin species from the South Shetland Islands and the Antarctic Peninsula for avian avulaviruses. We show that Adelie penguins (Pygoscelis adeliae) are hosts for four different avian avulavirus species, the recently described avian avulaviruses 17 to 19 and avian avulavirus 10-like, never before isolated in Antarctica. A total of 24 viruses were isolated and sequenced; avian avulavirus 17 was the most common, and phylogenetic analysis demonstrated patterns of occurrence, with different genetic clusters corresponding to penguin age and location. Following infection in specific-pathogen-free (SPF) chickens, all four avian avulavirus species were shed from the oral cavity for up to 7 days postinfection. There was limited shedding from the cloaca in a proportion of infected chickens, and all but one bird seroconverted by day 21. No clinical signs were observed. Taken together, we propose that penguin species, including Antarctic penguins, may be the central reservoir for a diversity of avian avulavirus species and that these viruses have the potential to infect other avian hosts. IMPORTANCE Approximately 99% of all viruses are still to be described, and in our changing world, any one of these unknown viruses could potentially expand their host range and cause epidemic disease in wildlife, agricultural animals, or humans. Avian avulavirus 1 causes outbreaks in wild birds and poultry and is thus well described. However, for many avulavirus species, only a single specimen has been described, and their viral ecology and epidemiology are unknown. Through the detection of avian avulaviruses in penguins from Antarctica, we have been able to expand upon our understanding of three avian avulavirus species (avian avulaviruses 17 to 19) and report a potentially novel avulavirus species. Importantly, we show that penguins appear to play a key role in the epidemiology of avian avulaviruses, and we encourage additional sampling of this avian group.

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Section: Introductionmentioning

confidence: 99%

Antarctic Penguins as Reservoirs of Diversity for Avian Avulaviruses

Wille

Aban

Wang

et al. 2019

J Virol

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“…Viruses of the subfamily Avulavirinae , previously designated avian avulaviruses (AAvV), are enveloped, non-segmented negative-sense single stranded RNA viruses, which are in the range of 14.9 to 17.4 kb in length, encode up to nine different proteins [3] and have the capacity to cause diseases with varying clinical manifestations in more than 200 wild and domestic bird species [4]. There are currently three genera ( Metaavulavirus , Orthoavulavirus and Paraavulavirus ) within Avulavirinae , including 20 described serotypes (-1 to -20), based on haemagglutination inhibition (HI) and neuraminidase inhibition (NI) assays and genetic sequencing [5,6,7,8,9,10]. In detail, Metaavulavirus contains ten species of avian metaavulavirus (AMAV), including serotypes -2, -5, -6, -7, -8, -10, -11, -14, -15 and -20, Orthoavulavirus contains eight species of avian orthoavulavirus (AOAV), including serotypes -1, -9, -12, -13, -16, -17, -18 and -19, while only two serotypes (-3 and -4) of avian paraavulavirus (APAV) are grouped into the genus of Paraavulavirus [11].…”

Section: Introductionmentioning

confidence: 99%

The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype

Fei

Liu

et al. 2019

Viruses

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Avian orthoavulavirus 13 (AOAV-13), also named avian paramyxovirus 13 (APMV-13), has been found sporadically in wild birds around the world ever since the discovery of AOAV-13 (AOAV-13/wild goose/Shimane/67/2000) in a wild goose from Japan in 2000. However, there are no reports of AOAV-13 in China. In the present study, a novel AOAV-13 virus (AOAV-13/wild goose/China/Hubei/V93-1/2015), isolated from a wild migratory waterfowl in a wetland of Hubei province of China, during active surveillance from 2013 to 2018, was biologically and genetically characterized. Phylogenetic analyses demonstrated a very close genetic relationship among all AOAV-13 strains, as revealed by very few genetic variations. Moreover, pathogenicity tests indicated that the V93-1 strain is a low virulent virus for chickens. However, the genome of the V93-1 virus was found to be 16,158 nucleotides (nt) in length, which is 12 nt or 162 nt longer than the other AOAV-13 strains that have been reported to date. The length difference of 12 nt in strain V93-1 is due to the existence of three repeats of the conserved sequence, “AAAAAT”, in the 5′-end trailer of the genome. Moreover, the HN gene of the V93-1 virus is 2,070 nt in size, encoding 610 aa, which is the same size as the AOAV-13 strain from Japan, whereas that of two strains from Ukraine and Kazakhstan are 2,080 nt in length, encoding 579 aa. We describe a novel AOAV-13 in migratory waterfowl in China, which suggests that diversified trailer region sequences and HN gene lengths exist within serotype AOAV-13, and highlight the need for its constant surveillance in poultry from live animal markets, and especially migratory birds.

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“…Avian paramyxoviruses that have been isolated from birds; however, due to changes in taxonomy is now referred to as avian avulavirus (AAvV) (Amarasinghe et al., ). There are 13 described AAvV serotypes (AAvV‐1 to ‐13) based on neuraminidase inhibition tests and hemagglutination inhibition (HI), and eight another putative serotypes have been recently isolated (AAvV‐14 to ‐21) (Jeong et al., ; Lee et al., ; Neira et al., ; Thampaisarn et al., ; Thomazelli et al., ; Yamamoto, Ito, & Ito, ). While very limited information is known about the biological and molecular characteristics of AAvV‐2 to ‐21, extensive study has been mainly conducted on AAvV‐1 (Newcastle disease virus, NDV) (Cardenas‐Garcia et al., ; Umali, Ito, Katoh, & Ito, ).…”

Section: Introductionmentioning

confidence: 99%

Biological and phylogenetic characterization of a novel hemagglutination-negative avian avulavirus 6 isolated from wild waterfowl in China

Chen

Ding

Liu

et al. 2018

Transbound Emerg Dis

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Up to now only nine whole genome sequences of avian avulavirus 6 (AAvV-6) had been documented in the world since the first discovery of AAvV-6 (AAvV-6/duck/HongKong/18/199/77) at a domestic duck in 1977 from Hong Kong of China. Very limited information is known about the regularities of transmission, genetic and biological characteristics of AAvV-6 because of the lower isolation rate and mild losses for poultry industry. To better further explore the relationships among above factors, an AAvV-6 epidemiological surveillance of domestic poultry and wild birds in six provinces of China suspected of sites of inter-species transmission and being intercontinental flyways during the year 2013-2017 was conducted. Therefore, 9,872 faecal samples from wild birds and 1,642 cloacal and tracheal swab samples from clinically healthy poultry of live bird market (LBM) were collected respectively. However, only one novel hemagglutination-negative AAvV-6 isolate (AAvV-6/mallard/Hubei/2015) was isolated from a fresh faecal sample obtained from mallard at a wetland of Hubei province. Sequencing and phylogenetic analyses of this AAvV-6 isolate (AAvV-6/mallard/Hubei/2015) indicated that this isolate grouping to genotype I were epidemiological intercontinentally linked with viruses from the wild birds in Europe and America. Meanwhile, at least two genotypes (I and II) are existed within serotype AAvV-6. In additional, this novel hemagglutination-negative AAvV-6 isolate in chicken embryos restored its hemagglutination when pre-treated with trypsin. These findings, together with data from other AAvV-6, suggest potential epidemiological intercontinental spreads among AAvV-6 transmission by wild migratory birds, and reveal potential threats to wild birds and domestic poultry worldwide.

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Complete genome sequence of a novel avian paramyxovirus isolated from wild birds in South Korea

Cited by 24 publications

References 12 publications

Antarctic Penguins as Reservoirs of Diversity for Avian Avulaviruses

Antarctic Penguins as Reservoirs of Diversity for Avian Avulaviruses

The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype

Biological and phylogenetic characterization of a novel hemagglutination-negative avian avulavirus 6 isolated from wild waterfowl in China

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