Linalool-rich essential oils from the Amazon display antidepressant-type effect in rodents

Santos, Éverton Renan Quaresma Dos; Maia, C.S.F.; Fontes, Enéas A.; Melo, Ademar Soares; Pinheiro, Bruno Gonçalves; Maia, José Guilherme S.

doi:10.1016/j.jep.2017.10.013

Cited by 54 publications

(33 citation statements)

References 48 publications

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“…Studies have shown that linalool has sedative and hypnotic effects. Linalool is a major component of lavender and may be used subcutaneously, peritoneally, orally, or inhaled [17–19]. Studies have shown that linalool has a significant anxiolytic effect.…”

Section: Resultsmentioning

confidence: 99%

The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology

Ren

Ke³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The active component-target network and protein-protein interaction network of Compound Anshen essential oil were constructed. The target functions and related pathways were analyzed to explore the mechanism of Compound Anshen essential oil in the treatment of insomnia. GC-MS was used to detect the chemical composition of Compound Anshen essential oil, and the TCMSP, STITCH, TTD, and DrugBank databases were searched to predict and screen the targets of Compound Anshen essential oil in the treatment of insomnia. Cytoscape software was used to construct the network diagrams of the active component-action target and protein-protein interaction networks, ClueGO software was used to analyze the GO enrichment and KEGG pathway of the target, and the systemsDock website database was used for molecular docking. The analysis of the network results showed that the activity of Compound Anshen essential oil mainly involves biological processes such as the phospholipase C-activating G protein-coupled receptor signaling pathway, response to ammonium ions, calcium ion transport into the cytosol, and chloride transport. The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-α-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets. This study demonstrates the multicomponent, multitarget, and multichannel characteristics of Compound Anshen essential oil and provides a new therapeutic idea and method for further research on the mechanism of Compound Anshen essential oil in the treatment of insomnia.

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Section: Resultsmentioning

confidence: 99%

The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology

Ren

Ke³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Aniba is a genus of plants native to the Brazilian Amazon. It comprises 41 species, including Aniba rosaeodora, which have been reported to have sedative, antiviral, anticonvulsant, and antidepressant activities [94,95]. A. rosaeodora has been reported to be highly effective against head lice [32].…”

Section: Anibamentioning

confidence: 99%

“…A. rosaeodora has been reported to be highly effective against head lice [32]. Linalool has been identified as its major constituent [95].…”

Section: Anibamentioning

confidence: 99%

Essential Oils as a Potential Treatment Option for Pediculosis

et al. 2020

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Pediculosis is a prevalent ectoparasite infestation caused by lice. The head louse (Pediculus humanus capitis) and body louse (Pediculus humanus humanus) are obligatory parasites whose only known hosts are humans. Pediculosis is probably the most common ectoparasitic infestation, affecting up to 80% of the population in several countries, and particularly prevalent in the infant population worldwide. Several treatment options, including shampoos and creams containing insecticides, have been introduced for the treatment of pediculosis. Recently, the use of synthetic chemicals to control human lice has raised concerns pertaining to human health and the environment. Therefore, increasing efforts have been undertaken to develop effective pediculicides with low environmental toxicity and minimal environmental residual activity. In this study, we focus on the essential oils derived from 22 plant genera, their constituents, and the major factors that play important roles in the effectiveness of these oils in the treatment of pediculosis. Furthermore, we discuss the advantages and limitations of the mentioned essential oils, and ultimately suggest those demonstrating the most effective in vitro pediculicidal activities. The genera such as Aloysia, Cinnamomum, Eucalyptus, Eugenia, Lavandula, Melaleuca, Mentha, Myrcianthes, Origanum, Pimpinella, and Thymus appear to be more efficient against lice. These genera are rich in anethole, 1,8-cineole, cinnamaldehyde, p-cymene, eugenol, linalool, limonene, pulegone, terpinen-4-ol, and thymol compounds.

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“…(Macacaporanga), and Aeollanthus suaveolens Mart. (Catinga-de-mulata) are rich in linalool, which in synergism with other constituents, possesses antidepressant activity without compromising spontaneous locomotion or memory retention in treated animals [217]. Studies have revealed the excellent results of linalool in the central nervous system, promoting phospholipid homeostasis in neurological recovery after ischemia [218], as well as improvements in memory loss and behavioral effects in REM sleep deprivation modelling [219].…”

Section: Linaloolmentioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

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Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

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Linalool-rich essential oils from the Amazon display antidepressant-type effect in rodents

Cited by 54 publications

References 48 publications

The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology

The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology

Essential Oils as a Potential Treatment Option for Pediculosis

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

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