Antidiabetic effect of Achillea millefollium through multitarget interactions: α-glucosidases inhibition, insulin sensitization and insulin secretagogue activities

Chávez-Silva, Fabiola; Cerón-Romero, Litzia; Arias-Durán, Luis; Navarrete‐Vázquez, Gabriel; Almanza-Perez, Julio César; Román-Ramos, Rubén; Ramírez-Ávila, Guillermo; Perea-Arango, Irene; Villalobos‐Molina, Rafael; Estrada‐Soto, Samuel

doi:10.1016/j.jep.2017.10.005

Cited by 57 publications

(34 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another molecule identified by GC-MS analysis was the camphene. A recent study showed the antidiabetic effect of A. millefolium extracts (17). In our work, camphene molecule effects the increasing in expression of ADIPOQ (Adiponectin), a protein with a regulatory role in glucose metabolism and fatty acid oxidation (Fig.…”

Section: Discussionsupporting

confidence: 56%

Evaluation of Achillea millefolium essential oil compounds and biological effects on cervix cancer HeLa cell line

Acar

İbiş

Şimşek

et al. 2020

The EuroBiotech Journal

View full text Add to dashboard Cite

Yarrow essential oil is used in complementary and alternative therapy for several diseases. Biological effects of essential oils span various cells and microorganisms. The aim of this study was to investigate the effects of different concentrations of the essential oil obtained from the yarrow plant (Achillea millefolium) on HeLa (CCL-2) cells. The components of the essential oil were studied by means of GC-MS analysis. Out of 10 determined compounds in the essential oil; 1,8-Cineole, Camphor, Beta-eudesmol and Camphene were found to be higher than others; and their biological effects were depicted with Ingeniuty Pathway Analysis (IPA) analysis. Moreover, cell cycle and proliferation tests were conducted on HeLa cells where yarrow plant’s essential oil was used. When extracted yarrow oil applied on HeLA Cells, apoptotic effects had been determined, furthermore proliferation of these cells decreased. In addition, activation of cell cycle control points was observed . Essential oil components could arrest the development of HeLa cells due to induction of cellular damage control mechanisms. In conclusion, we propose that the essential oil had a more repressive effect on HeLa cells, decreases their proliferation and prevented the increase in the number of cells.

show abstract

Section: Discussionsupporting

confidence: 56%

Evaluation of Achillea millefolium essential oil compounds and biological effects on cervix cancer HeLa cell line

Acar

İbiş

Şimşek

et al. 2020

The EuroBiotech Journal

View full text Add to dashboard Cite

show abstract

“…Although an ethanolic extract of Yarrow has been described to improve the circulating glucose levels in a diabetic model [37], herein SFE Yarrow also improved the lipid profile and ameliorated the hepatic steatosis in an HFD model of obesity. Altogether, our results indicate that Yarrow SFE may be beneficial for obese and hypercholesterolemic patients.…”

Section: Discussionmentioning

confidence: 91%

Yarrow Supercritical Extract Ameliorates the Metabolic Stress in a Model of Obesity Induced by High-Fat Diet

et al. 2019

View full text Add to dashboard Cite

Nowadays, obesity and its associated metabolic disorders, including diabetes, metabolic syndrome, cardiovascular disease, or cancer, continue to be a health epidemic in westernized societies, and there is an increased necessity to explore anti-obesity therapies including pharmaceutical and nutraceutical compounds. Considerable attention has been placed on the identification of bioactive compounds from natural sources to manage the metabolic stress associated with obesity. In a previous work, we have demonstrated that a CO2 supercritical fluid extract from yarrow (Yarrow SFE), downregulates the expression of the lipogenic master regulator SREBF1 and its downstream molecular targets FASN and SCD in a tumoral context. Since obesity and diabetes are strongly considered high-risk factors for cancer development, herein, we aimed to investigate the potential therapeutic role of Yarrow SFE in the metabolic stress induced after a high-fat diet in mice. For this purpose, 32 C57BL/6 mice were distributed in four groups according to their diets: standard diet (SD); SD supplemented with Yarrow SFE (SD + Yarrow); high-fat diet (HFD); and HFD supplemented with Yarrow SFE (HFD + Yarrow). Fasting glycemia, insulin levels, homeostasis model assessment for insulin resistance (HOMA-IR), lipid profile, gene expression, and lipid content of liver and adipose tissues were analyzed after three months of treatment. Results indicate improved fasting glucose levels in plasma, enhanced insulin sensitivity, and diminished hypercholesterolemia in the HFD + Yarrow group compared to the HFD group. Mechanistically, Yarrow SFE protects liver from steatosis after the HFD challenge by augmenting the adipose tissue buffering capacity of the circulating plasma glucose.

show abstract

“…A described protocol was used (Chávez‐Silva et al, ). In brief, fasted diabetic mice were divided into groups of six animals each.…”

Section: Methodsmentioning

confidence: 99%

Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies

Guzmán-Ávila

Flores‐Morales

Paoli

et al. 2018

Drug Development Research

Self Cite

View full text Add to dashboard Cite

Hit, Lead & Candidate Discovery Protein tyrosine phosphatase 1B (PTP-1B) has attracted interest as a novel target for the treatment of type 2 diabetes, this because its role in the insulin-signaling pathway as a negative regulator. Thus, the aim of current work was to obtain seven ursolic acid derivatives as potential antidiabetic agents with PTP-1B inhibition as main mechanism of action. Furthermore, derivatives 1-7 were submitted in vitro to enzymatic PTP-1B inhibition being 3, 5, and 7 the most active compounds (IC = 5.6, 4.7, and 4.6 μM, respectively). In addition, results were corroborated with in silico docking studies with PTP-1B orthosteric site A and extended binding site B, showed that 3 had polar and Van der Waals interactions in both sites with Lys120, Tyr46, Ser216, Ala217, Ile219, Asp181, Phe182, Gln262, Val49, Met258, and Gly259, showing a docking score value of -7.48 Kcal/mol, being more specific for site A. Moreover, compound 7 showed polar interaction with Gln262 and Van der Waals interactions with Ala217, Phe182, Ile219, Arg45, Tyr46, Arg47, Asp48, and Val49 with a predictive docking score of -6.43 kcal/mol, suggesting that the potential binding site could be localized in the site B adjacent to the catalytic site A. Finally, derivatives 2 and 7 (50 mg/kg) were selected to establish their in vivo antidiabetic effect using a noninsulin-dependent diabetes mice model, showing significant blood glucose lowering compared with control group (p < .05).

show abstract

Antidiabetic effect of Achillea millefollium through multitarget interactions: α-glucosidases inhibition, insulin sensitization and insulin secretagogue activities

Cited by 57 publications

References 41 publications

Evaluation of Achillea millefolium essential oil compounds and biological effects on cervix cancer HeLa cell line

Evaluation of Achillea millefolium essential oil compounds and biological effects on cervix cancer HeLa cell line

Yarrow Supercritical Extract Ameliorates the Metabolic Stress in a Model of Obesity Induced by High-Fat Diet

Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies

Contact Info

Product

Resources

About