(+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway

Zhang, Xiong; Xu, Fang; Liu, Li; Li, Feng; Wu, Xuefeng; Shen, Yan; Sun, Yang; Wu, Xudong; Xu, Qiang

doi:10.1016/j.intimp.2017.10.002

Cited by 39 publications

(22 citation statements)

References 34 publications

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“…Recent studies have shown that a strong correlation between dysfunction of macrophages and the development of ulcerative colitis (Zhang et al, 2017b;Abron et al, 2018;Gan et al, 2018). Here, we proved that cinobufacini suppressed the infiltration of activated macrophages in DSS-induced colitis mice.…”

Section: Discussionsupporting

confidence: 58%

Cinobufacini Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice through Inhibiting M1 Macrophage Polarization

Wang

Bai

Weng

et al. 2019

J Pharmacol Exp Ther

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Cinobufacini is a traditional Chinese medicine used clinically that has antitumor and anti-inflammatory effects. It improves colitis outcomes in the clinical setting, but the mechanism underlying its function yet to be uncovered. We investigated the protective effects and mechanisms of cinobufacini on colitis using a dextran sulfate sodium (DSS)-induced colitis mouse model, mainly focusing on the impact of macrophage polarization. Our results showed that cinobufacini dramatically ameliorated DSS-induced colitis in mice. Cinobufacini treatment reduced the infiltration of activated F4/80 1 and/or CD68 1 macrophages into the colon in DSS-induced colitis mice. More importantly, cinobufacini significantly decreased the quantity of M1 macrophages and the expression of proinflammatory cytokines such as interleukin-6, tumor necrosis factor a, and inducible nitric oxide synthase. Cinobufacini also increased the population of M2 macrophages and the expression of anti-inflammatory factors such as interleukin-10 and arginase-1 in DSS-induced colitis mice. Furthermore, our study demonstrated that cinobufacini inhibited M1 macrophage polarization in lipopolysaccharide-induced RAW 264.7 cells. Mechanistically, our in vivo and in vitro results showed that cinobufacini inhibition of M1 macrophage polarization may be associated with the suppression of nuclear factor kB activation. Our study suggests that cinobufacini could ameliorate DSS-induced colitis in mice by inhibiting M1 macrophage polarization.

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Section: Discussionsupporting

confidence: 58%

Cinobufacini Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice through Inhibiting M1 Macrophage Polarization

Wang

Bai

Weng

et al. 2019

J Pharmacol Exp Ther

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“…The level of M1-associated cytokines dramatically decreased in the serum of DSS-induced mice after treatment, and M1 macrophage infiltration sharply decreased concomitantly with an increment in M2 macrophages and Caudin-1 protein level. Activation of M2 polarization by C.EDA could be achieved by promoting JAK2 that led to STAT3 translocation and activates M2-related cytokines [39]. Phosphorylated STAT3 up-regulation and the inhibition of NF-κB were reported to be essential for macrophage repolarization and switching M1 into M2 phenotype, a result that was confirmed by using withaferin-A (steroidal lactone purified from ginseng or Indian winter cherry) [56].…”

Section: Role Of Macrophages In Intestinal and Colorectal Diseasementioning

confidence: 99%

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Koh

Yang

Lai

et al. 2018

IJMS

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Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.

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“…Mitogen-activated protein kinase MAPK signal transduction pathways, such as ERK, JNK, and p38, play an important role in inflammatory responses, and a variety of terpenes have been shown to inhibit these signaling pathways and to exert anti-inflammatory activities in various experimental models [49,66,71,[87][88][89]97,100]. In addition, a recent study has reported that borneol induced the activation of M2 macrophages in a STAT3-dependent manner in a DSS-induced colitis model [96]. Unfortunately, little is known about how terpenes affect these signaling systems.…”

Section: Signal Transduction and Direct Targets Of Terpene Compoundsmentioning

confidence: 99%

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

Kim

Song

Cho

et al. 2020

IJMS

160

131

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Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosols containing these compounds may be related to beneficial effects of forest bathing. In this review, we surveyed studies analyzing BVOCs and selected the most abundant 23 terpenes and terpenoids emitted in forested areas of the Northern Hemisphere, which were reported to display anti-inflammatory activities. We categorized anti-inflammatory processes related to the functions of these compounds into six groups and summarized their molecular mechanisms of action. Finally, among the major 23 compounds, we examined the therapeutic potentials of 12 compounds known to be effective against respiratory inflammation, atopic dermatitis, arthritis, and neuroinflammation among various inflammatory diseases. In conclusion, the updated studies support the beneficial effects of forest aerosols and propose their potential use as chemopreventive and therapeutic agents for treating various inflammatory diseases.

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(+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway

Cited by 39 publications

References 34 publications

Cinobufacini Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice through Inhibiting M1 Macrophage Polarization

Cinobufacini Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice through Inhibiting M1 Macrophage Polarization

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

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