Linezolid-Resistant Enterococcus faecalis Infection Following Prolonged Low-Dosage Linezolid Treatment for Multidrug-Resistant Tuberculosis

Baccani, Ilaria; Antonelli, Alberto; Galano, Angelo; Bartalesi, Filippo; Bartoloni, Alessandro; Rossolini, Gian María

doi:10.1093/cid/cix729

Cited by 3 publications

(1 citation statement)

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“…Linezolid is a new oxazolidinone antibiotic used for infections caused by methicillin-resistant Staphylococcus and other species [1,2]. Linezolid is a promising antibiotic drug, but its use is limited by adverse effects with prolonged administration of 600 mg twice daily [3][4][5]. The pharmacokinetics of linezolid in healthy subjects [6] and in obese patients with cellulitis [7] have been reported.…”

Section: Introductionmentioning

confidence: 99%

Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus

Negishi

Mitsumatsu

Matsumura

et al. 2022

J Pharm Health Care Sci

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Background Linezolid is a new oxazolidinone antibiotic used for infections caused by methicillin-resistant Staphylococcus and other species. Case presentation Two cases of knee osteoarthritis with acute infection were successfully treated using linezolid. The plasma and synovial fluid concentrations of linezolid in two patients [women aged 69 and 73 years (cases 1 and 2)] with knee osteoarthritis infected with Staphylococcus aureus were measured after they were administered 600 mg twice daily by intravenous infusion. The plasma linezolid concentrations during knee surgery in case 1 at day 5 and in case 2 at day 2 were 19.6 and 15.6 μg/mL, respectively. The synovial fluid concentrations of linezolid in samples taken during surgery in case 1 and case 2 were 14.9 and 17.0 μg/mL, respectively; these values corresponded to ratios of synovial fluid/plasma of 76 and 109%. Possible metabolite 2-hydroxylated linezolid potentially mediated by cytochrome P450 2 J2 was not detected in the plasma or synovial fluid samples under the current clinical setting after multiple doses. Conclusions These results implied nearly equivalent concentrations of linezolid in plasma and synovial fluid of clinical patients with knee osteoarthritis acutely infected with Staphylococcus aureus.

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