29  Inorganic pharmaceuticals

Blower, Philip J.

doi:10.1039/b211477c

Cited by 6 publications

(6 citation statements)

References 423 publications

(213 reference statements)

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“…Cellular uptake behaviors of all clusters were also evaluated in the other cell lines such as human osteosarcoma (HOS) and lung epithelial carcinoma (A549) ones, and the same results were obtained (the data are not shown). In addition we have measured luminescence spectra of solid samples of K 4 6 ] Á 8H 2 O was luminescent both in the solid state and in aqueous solution [18,21]. It was found that compound 3 is also luminescent, and the coordination of PEGylated oligopeptide ligand to rhenium cluster complex results in a shift of the emission maximum wavelength from $635 nm in 1 to $665 nm in 3 (Fig.…”

Section: Resultsmentioning

confidence: 93%

“…So we carried out the cellular uptake experiments for K 4 (2) in HeLa cells. Confocal microscopic studies showed that rhenium cluster 1 did not enter cells even after incubation time of 5 h, while rhenium cluster 2 was found in cells and localized in cytoplasm and nucleus after 2 h and 5 h incubation ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Until now, the studies in this direction have been mainly focused on the development of mononuclear rhenium complexes [1][2][3][4][5][6]. In as much as the active elements in the procedure of radiotherapy are metal atoms, octahedral rhenium cluster complexes with a high content of a metal can be useful for such applications.…”

Section: Introductionmentioning

confidence: 99%

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Cellular uptake and cytotoxicity of octahedral rhenium cluster complexes

Choi

Brylev

et al. 2008

Journal of Inorganic Biochemistry

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

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Cellular uptake and cytotoxicity of octahedral rhenium cluster complexes

Choi

Brylev

et al. 2008

Journal of Inorganic Biochemistry

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“…It is well established that organotin(IV) compounds are very important in cancer chemotherapy because of their apoptotic inducing character [6,7]. The design of improved organotin(IV) antitumour agents occupies a significant place in cancer chemotherapy, as revealed from their remarkable therapeutic potential reflected in recent research reports [8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Amino acetate functionalized Schiff base organotin(IV) complexes as anticancer drugs: synthesis, structural characterization, and in vitro cytotoxicity studies

Baul

Basu

Vos³

et al. 2008

Invest New Drugs

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Potassium 2-{[(2Z)-(3-hydroxy-1-methyl 2-butenylidene)]amino}-4-methyl-pentanoate (L1HK) and potassium 2-{[(E)-1-(2-hydroxyphenyl)alkylidene]amino}-4-methyl-pentanoates (L2HK-L3HK) underwent reactions with PhnSnCl4-n (n = 2 and 3) to give the amino acetate functionalized Schiff base organotin(IV) complexes [Ph3SnLH]n (1-3) and [Ph2SnL] (4), respectively. These complexes have been characterized by 1H, 13C, 119Sn NMR, IR spectroscopic techniques in combination with elemental analyses. The crystal structures of 1 and 3 were determined. The crystal structures reveal that the complexes exist as polymeric chains in which the L-bridged Sn-atoms adopt a trans-R3SnO2 trigonal bipyramidal configuration with the Ph groups in the equatorial positions and the axial locations occupied by a carboxylate oxygen atom from one carboxylate ligand and the alcoholic or phenolic oxygen atom of the next carboxylate ligand in the chain. The carboxylate ligands coordinate in the zwitterionic form with the alcoholic/phenolic proton moved to the nearby nitrogen atom. The solution structures were predicted by 119Sn NMR spectroscopy. When these organotin(IV) complexes were tested against A498, EVSA-T, H226, IGROV, M19 MEL, MCF7 and WIDR human tumor cell lines, the average ID50 values obtained were 55, 80 and 35 ng/ml for triphenyltin(IV) compounds 1-3, respectively. The most cytotoxic triphenyltin(IV) compound in the present report (3) with an average ID50 value of around 35 ng/ml is found to be morer cytotoxic for all the cell lines studied than doxorubicin, cisplatin, 5-fluorouracil and etoposide. (3) with an average ID 50 value of around 35 ng/ml is found to be morer cytotoxic for all the cell lines studied than doxorubicin, cisplatin, 5-fluorouracil and etoposide.

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“…In recent years, several metal complexes, such as zinc-containing polaprezinc (Matsukura & Tanaka 2000) and aluminum-containing sucralfate (Lazzaroni et al 1999) as anti-gastric-ulcer drugs, gold-containing auranofin (Simon 2000) as an antirheumatoid-arthritis drug and platinum-containing cisplatin (Takahashi et al 2002) as an anticancer drug, have been used as therapeutic agents (Blower 2003). Vanadium ions have been found to exhibit an insulinomimetic action (Shechter & Shisheva 1993;Sakurai et al 2002Sakurai et al , 2003Thompson & Orvig 2004).…”

Section: Introductionmentioning

confidence: 99%

Improvement of diabetic states in streptozotocin-induced type 1 diabetic rats by vanadyl sulfate in enteric-coated capsules

Fugono

Yasui

2005

Journal of Pharmacy and Pharmacology

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Chronic oral administration of vanadyl sulfate has recently been shown to improve the state of type 2 diabetic subjects. Mild gastrointestinal symptoms and side effects, however, have been observed in some subjects. To find safer and more effective dosages, we have developed an enteric-coated capsule containing solid vanadyl sulfate (ECC/VS), which enhances the bioavailability of vanadyl sulfate to almost double that of vanadyl sulfate solution. ECC/VS was chronically administered to treat streptozotocin-induced diabetic rats (STZ-rats), an animal model of type 1 diabetes mellitus, and an equivalent blood-glucose-lowering effect was observed at half the doses of vanadyl sulfate alone. In addition, we observed almost the same total vanadium levels in the serum after chronic administration of ECC/VS as those of vanadyl sulfate alone, suggesting that plasma vanadium levels correlate with the hypoglycaemic activity of vanadyl sulfate. These results indicate that oral ECC/VS improves the diabetic state by enhancing the uptake of vanadium in STZ-rats. These findings will be useful in designing clinical trials of vanadyl sulfate for diabetic subjects.

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29 Inorganic pharmaceuticals

Cited by 6 publications

References 423 publications

Cellular uptake and cytotoxicity of octahedral rhenium cluster complexes

Cellular uptake and cytotoxicity of octahedral rhenium cluster complexes

Amino acetate functionalized Schiff base organotin(IV) complexes as anticancer drugs: synthesis, structural characterization, and in vitro cytotoxicity studies

Improvement of diabetic states in streptozotocin-induced type 1 diabetic rats by vanadyl sulfate in enteric-coated capsules

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