Metabolic imaging of fatty kidney in diabesity: validation and dietary intervention

Jonker, Jacqueline T.; Heer, Paul de; Engelse, Marten A.; Rossenberg, Evelien H. van; Klessens, Celine Q F; Baelde, Hans J.; Bajema, Ingeborg M.; Koopmans, S.J.; Coelho, Paulo G.; Streefland, Trea C M; Webb, Andrew; Dekkers, Ilona A.; Rabelink, Ton J.; Rensen, Patrick C.N.; Lamb, Hildo J.; Vries, Aiko P. J. de

doi:10.1093/ndt/gfx243

Cited by 23 publications

(31 citation statements)

References 25 publications

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“…More precise multi-echo-Dixon-VIBE-sequences such as used in other studies studying intrarenal lipids [40] were acquired in this study cohort, but were centered on the liver, so that the kidneys were only partially covered. Alternatively, magnetic resonance spectroscopy may be a reliable tool to study intrarenal lipids [43]. Our data was based on semi-automated segmentation and voxel-based volumetry of T1w-Dixon images.…”

Section: Discussionmentioning

confidence: 99%

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Notohamiprodjo

Goepfert

Will³

et al. 2020

PLoS ONE

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We hypothesize that MRI-based renal compartment volumes, particularly renal sinus fat as locally and potentially independently acting perivascular fat tissue, increase with glucose intolerance. We therefore analyze the distribution of renal volumes in individuals with normal glucose levels and prediabetic and diabetic individuals and investigate potential associations with other typical cardiometabolic biomarkers. Material and methods The sample comprised N = 366 participants who were either normoglycemic (N = 230), had prediabetes (N = 87) or diabetes (N = 49), as determined by Oral Glucose Tolerance Test. Other covariates were obtained by standardized measurements and interviews. Wholebody MR measurements were performed on a 3 Tesla scanner. For assessment of the kidneys, a coronal T1w dual-echo Dixon and a coronal T2w single shot fast spin echo sequence were employed. Stepwise semi-automated segmentation of the kidneys on the Dixon-sequences was based on thresholding and geometric assumptions generating volumes for the kidneys and sinus fat. Inter-and intra-reader variability were determined on a subset of 40 subjects. Associations between glycemic status and renal volumes were evaluated by linear regression models, adjusted for other potential confounding variables. Furthermore, the association of renal volumes with visceral adipose tissue was assessed by linear regression models and Pearson's correlation coefficient.

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Section: Discussionmentioning

confidence: 99%

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Notohamiprodjo

Goepfert

Will³

et al. 2020

PLoS ONE

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“…The fatty kidney condition has been widely described in the literature [70][71][72][73][74]. This pathological condition is characterized by lipid accumulation in the renal parenchyma causing damage to various cells, including podocytes, proximal tubular epithelial cells, and the tubulointerstitial tissue through various mechanisms, being potentially detrimental to renal function in the long term [70][71][72][73][74]. On the other hand, DN patients usually have albuminuria, which is a well-known risk factor for the progression of renal disease [51,61].…”

Section: The Fatty Kidney In Dnmentioning

confidence: 99%

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Opazo-Ríos

Mas

Marín-Royo

et al. 2020

IJMS

192

147

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Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumulation have been associated with the development of kidney diseases, in particular diabetic nephropathy. Chronic hyperinsulinemia, often seen in type 2 diabetes, plays a crucial role in blood and liver lipid metabolism abnormalities, thus resulting in increased non-esterified fatty acids (NEFA). Excessive lipid accumulation alters cellular homeostasis and activates lipogenic and glycogenic cell-signaling pathways. Recent evidences indicate that both quantity and quality of lipids are involved in renal damage associated to lipotoxicity by activating inflammation, oxidative stress, mitochondrial dysfunction, and cell-death. The pathological effects of lipotoxicity have been observed in renal cells, thus promoting podocyte injury, tubular damage, mesangial proliferation, endothelial activation, and formation of macrophage-derived foam cells. Therefore, this review examines the recent preclinical and clinical research about the potentially harmful effects of lipids in the kidney, metabolic markers associated with these mechanisms, major signaling pathways affected, the causes of excessive lipid accumulation, and the types of lipids involved, as well as offers a comprehensive update of therapeutic strategies targeting lipotoxicity.

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“…Examples of relatively mature areas that would benefit from recommendations are renal dynamic contrast-enhanced MRI or MRI renography [28][29][30][31][32][33][34], phasecontrast MRI of the renal arteries [35][36][37][38], or MRI volumetry [39][40][41][42]. Emerging methods such as magnetisation transfer imaging [43,44], renal MR elastography [45][46][47][48], renal MRI spectroscopy [49,50], positron emission tomography (PET)/MRI [51], chemical exchange saturation transfer (CEST) [52], 7T renal MRI [53], 23 Na MRI [54] and hyperpolarised [1-13 C]pyruvate MRI [55] and 129 Xe MRI could also be potential candidates for recommendations. Other perspectives that could be taken in future work include the development of recommendations for biomarker panels where different complementary multiparametric sequences are run in the same study, or dedicated recommendations for cross-cutting issues such as region of interest (ROI) definition.…”

Section: Future Developmentsmentioning

confidence: 99%

Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

Mendichovszky

Pullens

Dekkers

et al. 2019

Magn Reson Mater Phy

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Purpose The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. The PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on renal MRI. Methods A task force was formed in July 2018 focused on five methods. A draft process for attaining consensus was distributed publicly for consultation and finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between October 2018 and March 2019, discussed results and refined the surveys at a face-to-face meeting (Aarhus, March 2019) and completed a second round (May 2019). Results A seven-stage process was defined: (1) formation of expert panels; (2) definition of the context of use; (3) literature review; (4) collection and comparison of MRI protocols; (5) consensus generation by an approximate Delphi method; (6) reporting of results in vendor-neutral and vendor-specific terms; (7) ongoing review and updating. Application of the process resulted in 166 consensus statements. Conclusion The process generated meaningful technical recommendations across very different MRI methods, while allowing for improvement and refinement as open issues are resolved. The results are likely to be widely supported by the renal MRI community and thereby promote more harmonisation.

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Metabolic imaging of fatty kidney in diabesity: validation and dietary intervention

Cited by 23 publications

References 25 publications

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

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