Screening for Breast Cancer

Niell, Bethany L.; Freer, Phoebe E.; Weinfurtner, R. Jared; Arleo, Elizabeth Kagan; Drukteinis, Jennifer S.

doi:10.1016/j.rcl.2017.06.004

Cited by 134 publications

(113 citation statements)

References 116 publications

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“…Mammography is the standard imaging modality for early detection of breast cancer. However, women with dense breast tissue, mammography is less sensitive and not all breast cancers can be detected [31]. Colonoscopy and bronchoscope are effective methods for diagnosing colorectal and lung cancers respectively [32,33].…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

Ge¹,

Yuan²,

Hu³

et al. 2020

Preprint

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Cancer is a disturbing disease with high morbidity and mortality. Although medical technology has been developed rapidly, diagnosis of cancer is still complicated, difficult, as well as expensive. Furthermore, cancers are mostly diagnosed at an advanced stage. Platelets mRNA profiles are altered after educated by tumors. Thereby, tumor-educated platelets (TEPs) mRNA profiles have the potentially diagnostic value for cancers currently. We downloaded and analyzed the next-generation sequencing datasets, GSE68086 and GSE89843, by integrated bioinformatics. A total of 43 biomarker genes were selected for further pathway enrichment analysis and correlation analysis, as well as diagnostic analysis. Gene ontology (GO) analysis showed these 43 TEPs mRNAs were mostly involved in protein binding, extracellular matrix and cellular protein metabolic process. Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis revealed that genes were mainly enriched in metabolic process. Eventually, after taking these 43 genes into spearman correlation analysis and receiving operating characteristic (ROC) curve analysis, we identified: 1) TEPs RSL24D1 mRNA was negatively related to early pan cancer as compared to healthy controls, and potential for early pan cancer diagnosis with a sensitivity of 71.8%, and a specificity of 64.3%; 2) HPSE, IFI27, LGALS3BP, CRYM, HBD, COL6A3, LAMB2, and IFITM3 showed an upward trend in the expression from early to more advanced pan cancer stages. The sensitivity of the diagnostic value for pan cancer of these genes was 60.9%, 59.1%, 56.5%, 57.8%, 54.3%, 55.2%, 55.2%, 60.9%, and a specificity of 94.5%, 90.9%, 87.3%, 89.1%, 72.7%, 85.5%, 89.1%, 94.5% respectively; 3) ARL2, FCGR2A, and KLHDC8B were positively associated with advanced, metastatic pan cancer as compared to healthy controls and could be diagnostic indicators for advanced pan cancer with a sensitivity of 59.2%, 61.8%, 59.7%, and a specificity of 80%, 89.1%, 83.6%, respectively. In summary, our findings identified that the 12-gene TEP liquid-biopsy biomarkers will not only facilitate early diagnosis of pan cancer, but also be beneficial to pan cancer staging.

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Section: Discussionmentioning

confidence: 99%

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

Ge¹,

Yuan²,

Hu³

et al. 2020

Preprint

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“…Para peneliti meyakini bahwa keadaan sosioekonomi, perubahan gaya hidup serta perubahan pola menstruasi, ternyata berkaitan dengan peningkatan risiko untuk terjadinya kanker payudara. 3,4 Kanker payudara ini sendiri merupakan salah satu masalah yang besar yang dialami para penduduk di Indonesia. Contohkan saja di bali, masalah kanker payudara masih sangat banyak terjadi, dan kebanyakan memiliki prognosis yang buruk.…”

Section: Abstrakunclassified

Ketepatan ultrasonografi dan mammografi dalam mendiagnosis wanita dengan kanker payudara di RSUP Sanglah Denpasar

Baruna¹,

Manuaba²

2019

Intisari Sains Medis

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Introduction: The high incidence of breast cancer in women, accompanied by delays in making contact with medical personnel and the absence of good early detection contribute to the very high mortality caused by breast cancer. Early detection using ultrasound and mammographic modalities plays an important role in the early diagnosis of breast cancer which will have an impact on the survival of patients. This study aims to compare the diagnostic values of ultrasonography and mammography compared with histopathological features in patients with breast cancer. Methods: This study used a diagnostic test design with a retrospective approach that compared sensitivity values, specificity, positive predictive value (PPV), negative predictive value (NPV), likelihood ratio from mammography and ultrasonography to histopathological morphology in patients with breast cancer at Sanglah General Hospital Denpasar. Results: It can be seen that in the total sample, ultrasonography in the toal condition of the sample has a diagnostic value that is very similar to mammography in establishing a diagnosis of breast cancer. Whereas at the age of> 40 years mammography has a diagnostic test value that is far better than ultrasonography (

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“…Since then, the surgical techniques have been refined and other treatment modalities have been introduced such as radiotherapy in the 1930s, adjuvant chemo-and hormonal therapy in the 70s, and since the turn of the millennium, new targeted drugs. Furthermore, in the 70s and 80s screening mammography was introduced throughout the Western world, including Sweden, and pooled estimates from several randomized control trials have shown a reduction in breast cancer mortality by at least 20 % due to screening (4). Taken together breast cancer mortality rate in the European Union has declined since the peak rate in 1989 of more than 20 /100,000 to an estimated 13.4 / 100,000 in 2020 (5).…”

Section: Introductionmentioning

confidence: 99%

The effects of flaxseed and tamoxifen on the inflammatory microenvironment in normal breast tissue and in breast cancer

Lindahl

2019

Linköping University Medical Dissertations

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Screening for Breast Cancer

Cited by 134 publications

References 116 publications

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

Ketepatan ultrasonografi dan mammografi dalam mendiagnosis wanita dengan kanker payudara di RSUP Sanglah Denpasar

The effects of flaxseed and tamoxifen on the inflammatory microenvironment in normal breast tissue and in breast cancer

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