The effect of vocal fold augmentation on cough symptoms in the presence of glottic insufficiency

Litts, Juliana K.; Fink, Daniel; Clary, Matthew S.

doi:10.1002/lary.26914

Cited by 16 publications

(22 citation statements)

References 15 publications

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“…Thirty‐seven articles 2,7,11–13,19,21–23,25,29–33,35–44,46–51,54,55,57,58,60,63 had sufficient information to perform meta‐analysis (Figure 1). There were 30 RCTs 7,19,20,22,23,25–28,30,32,34–37,39,40,42–45,48,50,51,53,56,57,59,62,64 (including three unpublished completed clinical trials 20,27,34 ), 10 retrospective case series, 2,11–13,31,46,49,55,58,63 nine prospective case series, 21,29,33,38,47,52,54,60,61 one prospective cohort study, 24 and one retrospective cohort study 41 . For studies that produced more than one manuscript, each article was assessed for unique patient data 28,40,53,64 …”

Section: Resultsmentioning

confidence: 99%

“…SLN block – either via injection of local anesthetic with corticosteroid or surgical transection – could provide a potential therapeutic option for NC that avoids the side effects of commonly used medications. Other recently described procedural treatments for NC include botulinum toxin (BTX) injection of laryngeal muscles 12 and vocal fold augmentation with temporary filler, such as methylcellulose or hyaluronic acid 13 …”

Section: Introductionmentioning

confidence: 99%

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Curbing the Cough: Multimodal Treatments for Neurogenic Cough: A Systematic Review and Meta‐Analysis

et al. 2020

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Objectives/Hypothesis Neurogenic cough affects 11% of Americans and causes significant detriment to quality of life. With the advent of novel therapies, the objective of this review is to determine how procedural therapies (e.g., superior laryngeal nerve block) compare to other established pharmacologic and non‐pharmacologic treatments for neurogenic cough. Methods With the assistance of a medical librarian, a systematic review was performed using PICOS (patients, interventions, comparator, outcome, study design) format: adults with neurogenic cough receiving any pharmacologic or non‐pharmacologic treatment for neurogenic cough compared to adults with neurogenic cough receiving any other relevant interventions, or treated as single cohorts, assessed with cough‐specific quality of life outcomes, in all study designs and case series with ≥ 10 cases. Case reports, review articles, non‐human studies, non‐English language articles, and unavailable full‐text articles were excluded. Results There were 2408 patients with neurogenic cough in this review, treated with medical therapy (77%), speech therapy (19%), both medical and speech therapy (1%), and procedural therapy (3%). The included studies ranged from low to intermediate quality. Overall, most interventions demonstrated successful improvement in cough. However, the heterogeneity of included study designs precluded direct comparisons between intervention types. Conclusion This meta‐analysis compared various treatments for neurogenic cough. Procedural therapy should be considered in the armamentarium of neurogenic cough treatments, particularly in patients refractory to, or intolerant of, the side effects of medical therapy. Lastly, this review illuminates key areas for improving neurogenic cough diagnosis, such as strict adherence to diagnostic and treatment guidelines, sophisticated reflux testing, and standardized, consistent outcome reporting. Laryngoscope, 132:107–123, 2022

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curbing the Cough: Multimodal Treatments for Neurogenic Cough: A Systematic Review and Meta‐Analysis

et al. 2020

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“…Other procedural treatments for neurogenic cough have been described, including Botox to the laryngeal musculature and injection augmentation . In those with glottic insufficiency, injection augmentation is felt to reduce laryngeal trauma and by feedback, reduce cough symptoms …”

Section: Discussionmentioning

confidence: 99%

Superior laryngeal nerve block for neurogenic cough: A case series

Dhillon

2019

Laryngoscope Investig Oto

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Objectives To demonstrate that an in‐office superior laryngeal nerve (SLN) block with lidocaine and steroids is an effective alternative to neuromodulators for patients with neurogenic cough. Study Design Retrospective study. Methods A retrospective review of 10 patients who underwent in office nerve block to the laryngeal nerve (SLN) for neurogenic cough. Demographic data and pre‐ and postcough survey index are the measure outcomes. Follow‐up was 3–6 months. Results We find that all patients in this study that underwent an SLN block showed significant improvement in cough severity index (CSI). The average number of blocks was 2.3. The mean follow‐up time from the first SLN block is 3.4 months. The mean CSI improvement 16.30. 95% confidence interval, 11.44–21.16; P < .0001. All patients in this study completed at least one session of cough suppression therapy with speech language pathology (SLP). No patients were on neuromodulators at the time of the SLN block. Conclusions There is a role for in‐office SLN block with lidocaine and steroids for patients with neurogenic cough, and can be an effective alternative to neuromodulators. Level of Evidence NA

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“…For those who undergo treatment, several studies have demonstrated improvement of both dysphagia and dysphonia with early initiation of speech therapy, as well as injection laryngoplasty 13,26‐31 . Injection laryngoplasty significantly reduces the rate of aspiration, returning patients to a regular diet 32‐39 . Patients with unilateral VFP who undergo early injection laryngoplasty are less likely to require long‐term medialization procedures in the form of thyroplasty than those who did not receive early injection laryngoplasty 40 .…”

Section: Resultsmentioning

confidence: 99%

“…13,[26][27][28][29][30][31] Injection laryngoplasty significantly reduces the rate of aspiration, returning patients to a regular diet. [32][33][34][35][36][37][38][39] Patients with unilateral VFP who undergo early injection laryngoplasty are less likely to require long-term medialization procedures in the form of thyroplasty than those who did not receive early injection laryngoplasty. 40 Investigations of treatments, like nimodipine in the acute period of VFP, are promising but requires further evaluation before being widely adopted.…”

Section: Statement 1: Immediate Vocal Fold Paralysismentioning

confidence: 99%

Immediate and partial neural dysfunction after thyroid and parathyroid surgery: Need for recognition, laryngeal exam, and early treatment

et al. 2020

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Background: Laryngeal dysfunction after thyroid and parathyroid surgery requires early recognition and a standardized approach for patients that present with voice, swallowing, and breathing issues. The Endocrine Committee of the American Head and Neck Society (AHNS) convened a panel to define the terms "immediate vocal fold paralysis" and "partial neural dysfunction" and to provide clinical consensus statements based on review of the literature, integrated with expert opinion of the group. Methods: A multidisciplinary expert panel constructed the manuscript and recommendations for laryngeal dysfunction after thyroid and parathyroid surgery. A meta-analysis was performed using the literature and published guidelines. Consensus was achieved using polling and a modified Delphi approach. Results: Twenty-two panelists achieved consensus on five statements regarding the role of early identification and standardization of evaluation for patients with "immediate vocal fold paralysis" and "partial neural dysfunction" after thyroid and parathyroid surgery. Conclusion: After endorsement by the AHNS Endocrine Section and Quality of Care Committee, it received final approval from the AHNS Council.

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The effect of vocal fold augmentation on cough symptoms in the presence of glottic insufficiency

Abstract: 4. Laryngoscope, 128:1316-1319, 2018.

Cited by 16 publications

References 15 publications

Curbing the Cough: Multimodal Treatments for Neurogenic Cough: A Systematic Review and Meta‐Analysis

Curbing the Cough: Multimodal Treatments for Neurogenic Cough: A Systematic Review and Meta‐Analysis

Superior laryngeal nerve block for neurogenic cough: A case series

Immediate and partial neural dysfunction after thyroid and parathyroid surgery: Need for recognition, laryngeal exam, and early treatment

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