Taiwanese and Japanese yam ( Dioscorea spp.) extracts attenuate doxorubicin-induced cardiotoxicity in mice

Chen, Chih-Tai; Wang, Zhihong; Hsu, Cheng‐Chin; Lin, Hui-Hsuan; Chen, Jing-Hsien

doi:10.1016/j.jfda.2016.09.002

Cited by 17 publications

(9 citation statements)

References 34 publications

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“…A dry extract of D.villosa were tested in acute and subchronic toxicity models in vivo but no evidence was found 26) . Species of Dioscorea attenuated cardiotoxicity induced by drugs as doxorubicin, in vivo 27) . The experimental GIC, which was incorporated into the extract obtained from D. altissima, showed a very good stability over the conventional cement, particularly in relation to syneresis, imbibition and solubility, higher surface microhardness, and a similar pattern of fluoride release and elasticity module was observed.…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties of a glass ionomer cement incorporated with Amazon plant extract

et al. 2019

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To evaluate the mechanical properties (MP) and antimicrobial activity of a glass ionomer cement (GIC) incorporated with an antimicrobial agent from the aerial parts of Dioscorea altissima. MP were: syneresis & imbibition; solubility; elasticity module; surface microhardness and fluoride release, and the anti-Streptococcus mutans (Smut) activity was accessed by microdilution broth assay and 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) analysis. Syneresis & imbibition did not change over time for both groups, but EG showed lower values at days 7th and 30th. The control group (CG)'s and the experimental group (EG)'s weights were similar before the solubility assay, but after seven days, CG exhibited weight gain in comparison to EG. The elasticity module had no significant differences between groups. The CG showed lower surface microhardness compared to the EG. CG and EG had similar behaviors regarding fluoride release. EG showed diminished Streptococcus mutans count in comparison to CG. EG showed similar or better mechanical properties and an improvement in the antibacterial activity than the original cement.

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Section: Discussionmentioning

confidence: 99%

Mechanical properties of a glass ionomer cement incorporated with Amazon plant extract

et al. 2019

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“…EDIP can be used for identification of cardiovascular disease risk factors (Farhangi et al, 2018). The ethanol and water extract of D. purpurea, D. japonica and D. alata have been reported to reduce the cardio-toxicity against doxorubicin (DOX)-induced myocardial infarction by reducing the level of TBARS, LDH, ROS and blood pressure (Chen et al, 2017;. DOX produces oxidative stress, increased blood pressure and activation of caspase 3 which leads to apoptosis.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Current Highlights on Biochemical and Pharmacological Profile of Dioscorea Alata : A Review

Kaur¹,

Khatun²,

Suttee³

2021

PLANT ARCHIVES

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Dioscorea alata, also known as water yam is an important plant found globally. Nearly 600 different yam species have been reported around the world. D. alata is an edible product, it is highly cultivated in countries like tropical South America, Africa, Australia, and South-eastern U.S. Dioscorea alata, commonly known as water yam, purple yam, ube, or greater yam has been reported to have diverse activities in various diseases. D. alata belongs to dioscoreaceae family and has been found to have antioxidant and anti-inflammatory, anti-apoptotic properties. The metabolic products of dioscorea alata are phenolic compounds, reducing sugars, flavonoids, glycoside, saponins, alkaloids, anthraquinones, proteins, tannins etc. The active constituents of D. alata are diosgenin, dioscorine, dioscin, cholin, mucin, allantoin, crude fat, crude fiber, catechins, chlorogenic acids, proanthocyanidins, myricetin, diosbulbin and sapogenin. Diosgenin is one of the main steroidal glycoside has been reported to have different activities like anti-diabetic activity, anti-hypertensive activity, anti-cancer activity, anti-inflammatory activity and cardio protective activity. Diosgenin is effective in heart disease due to the anti-oxidative and anti-apoptotic activity. Diosgenin has also been found to reduce oxidative stress and increase the levels of glutathione, SOD and catalase activity. Diosgenin also reported to inhibit the apoptosis by reducing the activation of caspase 9, a pro-apoptotic factor. Furthermore, bioactive compounds, including diosgenin, anthocyanins and dietary fiber of D. alata tuber has potential to prevent the condition of hyperlipidemia by normalizing blood lipid profiles. However, further investigations are required to find the effect of D. alata on cardiovascular disorders.

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“…Resistant starch from purple yam (D. alata) was effective against hyperlipidemia in high-fat diet-fed hamsters through the amelioration of lipid metabolism and the modulation of gut microbiota [196,198]. Moreover, extracts from roots significantly reduced blood glucose levels in Wistar rats with alloxan-induced hyperglycemia [199] or cholesterol (total and low-density lipoprotein (LDL)) and triglycerides in hypercholesterolemic rats [200], ameliorated doxorubicin (DOX)-induced cardiotoxicity [201], showed protective effects against aniline-induced spleen toxicity [202] and in vivo anti-inflammatory activities against λ-carrageenan-induced paw edema in mice [203], and could be used as an adjuvant in bone-marrow-derived dendritic cell (DC)-based vaccines for cancer therapy [204]. D. alata root extracts may also alleviate cellular fibrosis through the downregulation of the transforming growth factor-beta (TGF-β)/Smad signaling pathway and the modulation of epithelial-mesenchymal transition (EMT) expression in kidneys [205].…”

Section: Yammentioning

confidence: 99%

Grown to be Blue—Antioxidant Properties and Health Effects of Colored Vegetables. Part I: Root Vegetables

et al. 2019

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During the last few decades, the food and beverage industry faced increasing demand for the design of new functional food products free of synthetic compounds and artificial additives. Anthocyanins are widely used as natural colorants in various food products to replenish blue color losses during processing and to add blue color to colorless products, while other compounds such as carotenoids and betalains are considered as good sources of other shades. Root vegetables are well known for their broad palette of colors, and some species, such as black carrot and beet root, are already widely used as sources of natural colorants in the food and drug industry. Ongoing research aims at identifying alternative vegetable sources with diverse functional and structural features imparting beneficial effects onto human health. The current review provides a systematic description of colored root vegetables based on their belowground edible parts, and it highlights species and/or cultivars that present atypical colors, especially those containing pigment compounds responsible for hues of blue color. Finally, the main health effects and antioxidant properties associated with the presence of coloring compounds are presented, as well as the effects that processing treatments may have on chemical composition and coloring compounds in particular.

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Taiwanese and Japanese yam ( Dioscorea spp.) extracts attenuate doxorubicin-induced cardiotoxicity in mice

Cited by 17 publications

References 34 publications

Mechanical properties of a glass ionomer cement incorporated with Amazon plant extract

Mechanical properties of a glass ionomer cement incorporated with Amazon plant extract

Current Highlights on Biochemical and Pharmacological Profile of Dioscorea Alata : A Review

Grown to be Blue—Antioxidant Properties and Health Effects of Colored Vegetables. Part I: Root Vegetables

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