Predicting post‐hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis

Chuang, Yi‐Hsuan; Ou, Hsin‐You; Lazo, M.; Chen, Chao‐Long; Chen, Meng‐Hsiang; Weng, Ching‐Chun; Cheng, Yu‐Fan

doi:10.1111/liv.13608

Cited by 51 publications

(45 citation statements)

References 38 publications

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“…1 ). Orhan et al considered that if such tumor location as mentioned above precludes safe EN, anatomic resection is preferred [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and factors affecting the choice of enucleation and liver resection for giant hemangioma: a retrospective propensity score-matched study

Zhao

et al. 2020

BMC Surg

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Background Liver resection (LR) and enucleation (EN) are the main surgical treatment for giant hepatic hemangioma (HH), but how to choose the type of surgery is still controversial. This study aimed to explore the efficacy and the factors affecting the choice of open procedure for HH. Methods The data for patients with pathologically confirmed HH who underwent open surgery from April 2014 to August 2020 were analyzed retrospectively. Univariate and multivariate analyses with logistic regression were performed to disclose the factors associated with the choice of EN or LR. Propensity score matching (PSM) analysis was used to compare the efficacy of the two procedures. Results A total of 163 and 110 patients were enrolled in the EN and LR groups. Following 1:1 matching by PSM analysis, 66 patients were selected from each group. Centrally located lesions (OR: 0.131, 95% CI 0.070–0.244), tumors size > 12.1 cm (OR: 0.226, 95% CI 0.116–0.439) and multiple tumors (OR: 1.860, 95% CI 1.003–3.449) were independent factors affecting the choice of EN. There was no significant difference in the median operation time (156 vs. 195 min, P = 0.156), median blood loss (200 vs. 220 ml, P = 0.423), blood transfusion rate (33.3% vs. 33.3%, P = 1.000), mean postoperative feeding (3.1 vs. 3.3 d, P = 0.460), mean postoperative hospital stay (9.5 vs. 9.0 d, P = 0.206), or the major complication rates between the two groups. Conclusions Peripherally located lesions, tumors size ≤ 12.1 cm and multiple tumors were more inclined to receive EN. There was no significant difference in the efficacy of EN or LR.

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“…1 ). Orhan et al considered that if such tumor location as mentioned above precludes safe EN, anatomic resection is preferred [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and factors affecting the choice of enucleation and liver resection for giant hemangioma: a retrospective propensity score-matched study

Zhao

et al. 2020

BMC Surg

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“…Indocyanine green clearance is often considered essential, and a future liver remnant >40% (30% for patients without cirrhosis, just like the authors claimed in this study) is recommended to avoid LD after liver resection in patients with cirrhosis. (3)(4)(5) Accordingly, these patients are susceptible to LD for liver resection and could have different predictive parameters for this complication from patients without cirrhosis. To this end, the feasibility of these miRNA-based biomarkers for Asia-Pacific populations needs to be further discussed and evaluated.…”

Section: To the Editormentioning

confidence: 99%

“…Liver volume is an important factor affecting postoperative liver function recovery. (3) Standard residual liver volume (SRLV) and future liver remnant function (FLRV) can effectively predict the occurrence of postoperative liver dysfunction, (4,5) whereas liver resection volume and future liver volume are not effective. We believe that the results of this study may be more interesting if the study includes SRLV or FLRV.…”

Section: Letter To the Editor: Predicting Postoperative Liver Dysfuncmentioning

confidence: 99%

Letter to the Editor: Predicting Postoperative Liver Dysfunction Based on Blood Derived MicroRNA Signatures

Yuan

et al. 2019

Hepatology

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“…2 In the current clinical work, however, both surgeons and physicians are still faced with many cases who die due to insufficient liver regeneration. 3 For example, the residual liver tissue of patients with major hepatectomy fails to regenerate to full size and lead to the occurrence of posthepatectomy liver failure, 4,5 liver failure occurs in recipients of live donor liver transplantation due to the small-for-size syndrome, 6 and in patients with acute or chronic viral hepatitis, drug-induced liver damage, and alcoholic liver disease due to ineffective liver regeneration. 7 The mortality of patients with liver failure remains high, which causes a heavy burden on society and families.…”

Section: Introductionmentioning

confidence: 99%

Platelet microparticles‐derived miR‐25‐3p promotes the hepatocyte proliferation and cell autophagy via reducing B‐cell translocation gene 2

et al. 2020

J of Cellular Biochemistry

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Platelets are critical regulators of liver regeneration, but the mechanisms are still not fully understood. Platelets have been shown to contain a wide variety of microRNAs (miRNAs) and play an important role in many diseases. However, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate the hepatocyte proliferation is not very clear. In this study, we have successfully isolated and identified PMPs. We also found that PMPs, which could be well integrated into the HHL-5 cells, could upregulate the level of miR-25-3p in HHL-5 cells. Meanwhile, we found that PMPs-derived miR-25-3p promoted HHL-5 cells proliferation by accelerating cells into the S phase, and enhanced the autophagy by increasing the LC3II expression and reducing the P62 expression. Then, we proved that the miR-25-3p could target the B-cell translocation gene 2 (BTG2) and downregulate the expression levels of the BTG2 gene in HHL-5 cells. In addition, the overexpression of BTG2 significantly inhibited the proliferation and autophagy abilities of HHL-5 cells, while cotransfected miR-25-3p mimics or PMPs could partially rescue HHL-5 cells proliferation and autophagy. Furthermore, we proved that PMPs accelerated hepatocyte proliferation by regulating autophagy pathways. Therefore, PMPs-derived miR-25-3p promoted HHL-5 cell proliferation and autophagy by targeting BTG2, which may be a new therapeutic method for liver regeneration.

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Predicting post‐hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis

Abstract: Gadoxetic acid-enhanced MR imaging with volumetric is a reliable method for evaluating functional liver volume and determining the risk of PHLF.

Cited by 51 publications

References 38 publications

Efficacy and factors affecting the choice of enucleation and liver resection for giant hemangioma: a retrospective propensity score-matched study

Efficacy and factors affecting the choice of enucleation and liver resection for giant hemangioma: a retrospective propensity score-matched study

Letter to the Editor: Predicting Postoperative Liver Dysfunction Based on Blood Derived MicroRNA Signatures

Platelet microparticles‐derived miR‐25‐3p promotes the hepatocyte proliferation and cell autophagy via reducing B‐cell translocation gene 2

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