Thymic stromal lymphopoietin contribution to the recruitment of circulating fibrocytes to the lung in a mouse model of chronic allergic asthma

Abstract

Our data suggested that TSLP might function in airway remodeling by promoting circulating fibrocyte recruitment to the lung in the mice subjected to chronic allergen exposure. These results provide a better rationale for targeting the interaction between TSLP and fibrocytes as a therapeutic approach for chronic allergic asthma.

IL‐37 alleviates house dust mite‐induced chronic allergic asthma by targeting TSLP through the NF‐κB and ERK1/2 signaling pathways

“…We have previously demonstrated that production of TSLP was increased in the lung of asthmatic mice and TSLP level is associated with DC maturation and the extension of Th2‐biased inflammation . Our data showed that neutralization of TSLP with corresponding monoclonal antibody obviously alleviated allergen‐induced airway eosinophilic inflammation, inhibited production of Th2‐associated cytokines in the lung and subsequent airway remodeling . Individuals with one atopic disease are far more likely to develop a second disease.…”

“…As an epithelium‐derived cytokine, thymic stromal lymphopoietin (TSLP) has been suggested to be a master switch that initiates allergic inflammation in the lung and other tissues, including in those with asthma . In addition, we and others have demonstrated that TSLP was also involved in allergen‐induced airway remodeling by acting on airway structural cells, such as recruiting fibrocytes into the lung tissues, inducing airway smooth muscle cells migration, promoting fibroblast differentiation . These findings highlight the potential advantages of targeting TSLP, which may affect disease activity more broadly than the inhibition of a single downstream pathway.…”

“…The asthma model used in this study by short‐term exposure to aeroallergen extracts has been much less productive in advancing our understanding of the mechanisms and implications of chronic airway inflammation and remodeling. We and others have demonstrated that continuous exposure to HDM for 5 weeks elicited severe and persistent eosinophilic airway inflammation and subsequent structural remodeling . Our modeling approach used in this study was more representative of real‐life aeroallergen exposure and contributed to a better understanding of the effect and mechanism of IL‐37 in immune inflammatory processes in the airway associated with chronic allergen exposure.…”

“…It was previously reported that lung‐specific expression of TSLP resulted in AHR and neutralization of TSLP with monoclonal antibody could decrease AHR . To determine whether IL‐37 affects airway AHR by targeting TSLP, we obtained enhanced pause measurements both basally and in response to increasing doses of inhaled methacholine.…”

Endothelial cell‑derived CCL15 mediates the transmigration of fibrocytes through the CCL15‑CCR1 axis in vitro

“…Recruitment of fibrocytes into wound areas forms the basis of their functions (4). Thymic stromal lymphopoietin has been reported to function in airway remodeling by promoting CF recruitment to the lungs in mice subjected to chronic allergen exposure (7). In addition, contribution of chemokines chemokine ligand (CCL)5, CCL11 and CCL24 in the recruitment of fibrocytes to the airway in severe asthma has also been previously demonstrated (8).…”