Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients

Savoia, Paola; Zavattaro, Elisa; Cremona, Ottavio

doi:10.2174/0929867324666171003123056

Cited by 3 publications

(2 citation statements)

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“…Ideally, a skin cancer reduction programme should consist of utilisation of traditional educational methods (e.g. posters, brochures, bookmarks, pamphlets) 20–28 as well as mobile devices to improve sun‐protective behaviours, 23,27 direct face‐to‐face systematic self‐skin examination instruction to recognise suspicious skin lesions, 20,21 direct face‐to‐face appointment with a renal pharmacist to better understand immunosuppressant‐related cancer risks, 21 regular skin checks with a general practitioner, 20,21 evaluation in a multidisciplinary clinic for high‐risk patients, 22,24 introduction of a skin healthcare diary in which essential skin care information is shared among patients, general practitioners, nephrologists, surgeons, radiologists and dermatologists, 21 early detection of skin cancer and timely personalised modification of immunosuppressants 6 and consideration on the use of chemoprotective agents especially nicotinamide and retinoids in at‐risk patients 6,29–31 . We support the call to establish a skin cancer registry for transplant recipients based on Medicare data and the integration of a skin cancer reduction programme in this population, which is currently not readily available nationally.…”

Section: Discussionmentioning

confidence: 99%

Clinical and economic burden of benign and malignant skin lesions in renal transplant recipients

Thet

Lam

Pham³

et al. 2023

Internal Medicine Journal

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BackgroundStudies evaluating the economic burden of dermatological care in the transplant setting are currently not available in Australia.AimsTo evaluate the clinical and economic burden of benign and malignant skin lesions in renal transplant recipients in Central Queensland.MethodsA bottom‐up approach was used to determine the clinical burden and direct costs from patient‐level Medicare data obtained from Service Australia for skin lesions.ResultsSeventy‐six percent of the renal transplant population in Central Queensland participated in this study. The median age was 57.0 years (standard deviation ± 13.6) and the majority (61.8%) of participants were men. The mean duration after transplant surgery was 99.9 months (interquartile range, 73.2–126.6 months). During a 2‐year follow‐up, 22 (40%) patients were diagnosed with benign skin lesions, 21 (38%) with nonmelanoma skin carcinoma (NMSC) and one (2%) with melanoma. There was a total of 231 visits to clinicians for diagnostic and therapeutic skin procedures and the direct costs to Medicare was $48 806 Australian Dollars (AUD) or $30 427 US Dollars (USD). Approximately 86% of the total direct costs was spent for nonNMSC and mean direct costs for NMSC was $763 AUD (or $476 USD).ConclusionThis Medicare data‐based study provides further insight into the burgeoning clinical and economic burden of the care for benign and malignant skin lesions in the renal transplantation setting in Australia.

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Section: Discussionmentioning

confidence: 99%

Clinical and economic burden of benign and malignant skin lesions in renal transplant recipients

Thet

Lam

Pham³

et al. 2023

Internal Medicine Journal

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“…Chemoprevention is defined as the use of a drug or appropriate treatment to delay the onset of cancer or to return cancer to normal [ 11 ]. It takes over a decade for cancer to develop [ 12 , 13 ].…”

Section: Skin Carcinogenesis and Chemopreventionmentioning

confidence: 99%

NADPH Oxidase and Epidermal Growth Factor Receptor Are Promising Targets of Phytochemicals for Ultraviolet-Induced Skin Carcinogenesis

Kim

et al. 2021

Antioxidants

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The skin acts as the primary defense organ that protects the body from the external environment. Skin cancer is one of the most common cancers in the world. Skin carcinogenesis is usually caused by cell degeneration due to exposure to ultraviolet (UV) radiation, which causes changes in various signaling networks, disrupting the homeostasis of single skin cells. In this review, we summarize the roles of nicotinamide adenine dinucleotide phosphate oxidase (NOX) and epidermal growth factor receptor (EGFR) in UV-induced skin carcinogenesis. Furthermore, we describe the crosstalk that exists between NOX, EGFR, and protein tyrosine phosphatase κ and its oncogenic downstream signaling pathways. Chemoprevention is the use of chemical compounds to recover the healthy status of the skin or delay cancer development. Current evidence from in vitro and in vivo studies on chemopreventive phytochemicals that target NOX, EGFR, or both, as major regulators of skin carcinogenesis will also be discussed.

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Nicotinamide Attenuates UV-Induced Stress Damage in Human Primary Keratinocytes from Cancerization Fields

Camillo¹,

Gironi²,

Zavattaro³

et al. 2022

Journal of Investigative Dermatology

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Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients

Abstract: Chemoprevention would be key in controlling skin carcinogenesis in high-risk patients.

Cited by 3 publications

References 0 publications

Clinical and economic burden of benign and malignant skin lesions in renal transplant recipients

Clinical and economic burden of benign and malignant skin lesions in renal transplant recipients

NADPH Oxidase and Epidermal Growth Factor Receptor Are Promising Targets of Phytochemicals for Ultraviolet-Induced Skin Carcinogenesis

Nicotinamide Attenuates UV-Induced Stress Damage in Human Primary Keratinocytes from Cancerization Fields

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