Sensory axonal polyneuropathy due to 2,4-dinitrophenol

Izumoto, Shintaro; Taniguchi, Akitoshi; Mochizuki, Hitoshi; Shiomi, Kazutaka; Nakazato, Masamitsu

doi:10.5692/clinicalneurol.cn-001062

Cited by 1 publication

(1 citation statement)

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“…The interindividual sensitivity also varies according to time [260]. The reported side effects of DNP include acute cataract [261,262], sensory axonal polyneuropathy [263], fever, tachycardia, sweating, nausea, rash, breathing difficulties, abdominal pain, agitation, headache, and death [264,265]. More recently, an increase in the use of DNP as a self-medication has been observed in China [266] and the United Kingdom [267], leading to new cases of DNP-associated fatalities.…”

Section: Possible Use Of Mitochondrial Uncouplers For Human Diseasesmentioning

confidence: 99%

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Demine¹,

Renard

Arnould

2019

Cells

321

204

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Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis. Although this process was originally considered a mitochondrial dysfunction, the identification of UCP-1 as an endogenous physiological uncoupling protein suggests that the process could be involved in many other biological processes. In this review, we first compare the mitochondrial uncoupling agents available in term of mechanistic and non-specific effects. Proteins regulating mitochondrial uncoupling, as well as chemical compounds with uncoupling properties are discussed. Second, we summarize the most recent findings linking mitochondrial uncoupling and other cellular or biological processes, such as bulk and specific autophagy, reactive oxygen species production, protein secretion, cell death, physical exercise, metabolic adaptations in adipose tissue, and cell signaling. Finally, we show how mitochondrial uncoupling could be used to treat several human diseases, such as obesity, cardiovascular diseases, or neurological disorders.

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