Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake

Ambroziak, Urszula; Hybsier, Sandra; Shahnazaryan, Urszula; Krasnodębska-Kiljańska, Małgorzata; Rijntjes, Eddy; Bartoszewicz, Zbigniew; Bednarczuk, Tomasz; Schomburg, Lutz

doi:10.1016/j.jtemb.2017.08.005

Cited by 51 publications

(44 citation statements)

References 42 publications

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“…Although Kłapcińska et al study made in the same area as Krysiak et al proved that Se status was low especially in women (57.5 ±18.9 µg/L) [66] who were the only gender included in the study [65]. Other, more recent studies done on polish population confirms Kłapcińska et al results [67,68]. There were 47 subjects divided into 2 groups: Se-treated (n=23) who were supplementing selenomethionine for at least 12 months before the start of the study and throughout its duration and Se-naïve group.…”

Section: Selenium and Vitamin Dmentioning

confidence: 61%

Supplementation in Autoimmune Thyroid Hashimoto’s Disease. Vitamin D and Selenium

Ihnatowicz¹,

Wątor²,

Drywień³

2019

JFNR

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This review aims to present the importance of nutrients for thyroid health in light of autoimmune Hashimoto's disease. Authors focus mainly on vitamin D and selenium function in the body, metabolism, serum concentration in patients, replenishment outcome after singular or combined the treatment and dose. Vitamin D is essential for immune regulation and yields inflammatory properties. Selenium plays an important role in thyroid metabolism by protecting it from oxidative damage during iodine metabolism and by taking part in thyroid hormone production. Hashimoto is a complex disease and cross-curricular therapies probably will find more interest than oneway therapy.

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Section: Selenium and Vitamin Dmentioning

confidence: 61%

Supplementation in Autoimmune Thyroid Hashimoto’s Disease. Vitamin D and Selenium

Ihnatowicz¹,

Wątor²,

Drywień³

2019

JFNR

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“…Thus, we suggest that Recommendation 21 of the ATA guidelines be updated to a "weak recommendation" that LT4 therapy in euthyroid, TPOAb positive women undergoing ART is not recommended based on "moderatequality evidence. Although the prevalence of selenium deficiency increased throughout pregnancy in both groups, selenium levels were not any different in the presence or absence of thyroid autoimmunity, giving indirect evidence to support the theory that supplementation would not benefit those with thyroid autoimmunity (53).…”

Section: C) Autoimmunity and Preterm Delivery (Question 19)mentioning

confidence: 75%

The Need for Dynamic Clinical Guidelines: A Systematic Review of New Research Published After Release of the 2017 ATA Guidelines on Thyroid Disease During Pregnancy and the Postpartum

2020

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Background: The American Thyroid Association Guidelines on Thyroid Disease During Pregnancy and the Postpartum (ATA Guidelines) were published in 2017, with an update not expected for another 5 years. Since release of the 2017 ATA Guidelines, greater than 500 articles have been published in the field. Furthermore, there are presently 14 prospective, interventional trials in progress registered at Clinicaltrials.gov Static guidelines updated every 5-7 years fail to provide timely evidence-based guidance to practicing clinicians. Consequently, guideline development should move toward the creation of dynamic documents. The present article reviews the literature published since the 2017 ATA Guidelines, both to benefit clinicians in practice and to make the case for Dynamic ATA Guidelines. Methods: Using the search terms "thyroid" and "pregnancy," a systematic review of literature published in Pubmed from 3/1/2017 to 12/31/2018 was conducted. The titles and/or abstracts of all articles were reviewed. All articles were classified by subject headings used in the 2017 ATA Guidelines. English-text articles classified under "hypothyroidism" or "thyroid autoimmunity" were examined in full-text. Using the questions and recommendations put forth by the previous ATA Guidelines, relevant articles were selected for discussion in this review. Results: At the time of the search, 659 unique articles on "thyroid and pregnancy" were identified, including 66 original studies on hypothyroidism and 26 on thyroid autoimmunity. Of these, 26 studies on hypothyroidism and 18 studies on thyroid autoimmunity were selected for inclusion in this review based on specific questions in the 2017 ATA Guidelines. Based on these 44 articles, we propose two specific changes to the 2017 ATA Guidelines. Conclusion: Based on new research, we recommend the 2017 ATA Guidelines be updated to recommend against treating thyroid antibody-negative women diagnosed Dong et al. Thyroid in Pregnancy Since 2017 with subclinical hypothyroidism in the second trimester or later; to reflect new, moderate-quality evidence supporting the treatment of thyroid peroxidase antibody-negative women with elevated thyroid stimulating hormone levels in the first trimester or earlier; and to recommend against treatment of euthyroid, thyroid peroxidase antibody-positive women undergoing assisted reproductive technology. Transitioning to a Dynamic ATA Guidelines would allow for these and future recommendations to be implemented in real time.

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“…No difference in average TSH concentration was found in children born to AITD mothers in comparison with healthy mothers (1.4 ± 1.4 mIU/l vs 1.8 ± 1.4 mIU/l). Additionally, there was no correlation between the TSH values in the newborns and serum Se or SELENOP concentrations of their mothers [7].…”

Section: Se and Thyroid Autoimmunity And Fertility During Pregnancymentioning

confidence: 81%

“…Low Se status and decreased Se and thyroid antibody concentrations throughout pregnancy were found. Se deficit (< 45 μg/l) was observed in 0%, 3.4%, 28.6% and 4.5%, 18.2% and 35.5% of women in the AITD and control group during the 1st, 2nd, and 3rd trimester, respectively [7]. The decline in TPOAb and TG-Ab was unrelated to Se status.…”

Section: Se and Thyroid Autoimmunity And Fertility During Pregnancymentioning

confidence: 87%

“…Recently, Ambroziak et al published their results based on assessment of Se concentrations in a Polish population of pregnant women. Se status was assessed by serum Se and selenoprotein P (SELENOP) concentrations [7]. Low Se status and decreased Se and thyroid antibody concentrations throughout pregnancy were found.…”

Section: Se and Thyroid Autoimmunity And Fertility During Pregnancymentioning

confidence: 99%

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Pregnancy, thyroid, and the potential use of selenium

Hubalewska‐Dydejczyk

Duntas²,

Gilis‐Januszewska

2019

Hormones

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The management of pregnant women is a major concern of health care around the world. There is growing evidence regarding the influence of selenium (Se) on pregnancy and fetus outcomes. However, due to as yet insufficient evidence, lack of measurable markers to assess the effect of Se supplementation on the human metabolism, and Se's narrow therapeutic index, the majority of experts and the current guidelines published by several scientific societies do not recommend the use of Se in pregnancy and in women of childbearing age. Further research based on well-designed studies, including assessment of the complex interactions between different micronutrients and individual response to different doses of Se, is needed.

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Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake

Cited by 51 publications

References 42 publications

Supplementation in Autoimmune Thyroid Hashimoto’s Disease. Vitamin D and Selenium

Supplementation in Autoimmune Thyroid Hashimoto’s Disease. Vitamin D and Selenium

The Need for Dynamic Clinical Guidelines: A Systematic Review of New Research Published After Release of the 2017 ATA Guidelines on Thyroid Disease During Pregnancy and the Postpartum

Pregnancy, thyroid, and the potential use of selenium

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