Effects of immediate‐release niacin and dietary fatty acids on acute insulin and lipid status in individuals with metabolic syndrome

Paz, Sergio Montserrat‐de la; López, Sergio; Bermúdez, Beatriz; Guerrero, Juan M.; Abia, Rocı́o; Muriana, Francisco J.G.

doi:10.1002/jsfa.8704

Cited by 7 publications

(1 citation statement)

References 38 publications

(72 reference statements)

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“…In healthy subjects, serum TG levels reach a peak over 1-3 h after eating a fatty meal, resulting in postprandial TRL accumulation in the bloodstream [ 10 ]. In previous studies, our research team has demonstrated the superiority of dietary oleic acid (i.e., monounsaturated fatty acid, MUFA) over palmitic and stearic acid (i.e., saturated fatty acids, SFAs) in buffering silent alterations postprandially [ 11 , 12 , 13 ]. Postprandial disturbances have been markedly interconnected with oxidative and inflammatory process linked to the differentiation and activation of circulating myeloid cells [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation

et al. 2020

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Dietary fatty acids have been demonstrated to modulate systemic inflammation and induce the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial triglyceride-rich lipoproteins (TRLs) may have acute effects on immunometabolic homeostasis by modulating dendritic cells (DCs), sentinels of the immunity that link innate and adaptive immune systems. In healthy volunteers, saturated fatty acid (SFA)-enriched meal raised serum levels of granulocyte/macrophage colony-stimulating factor GM-CSF (SFAs > monounsaturated fatty acids (MUFAs) = polyunsaturated fatty acids (PUFAs)) in the postprandial period. Autologous TRL-SFAs upregulated the gene expression of DC maturation (CD123 and CCR7) and DC pro-inflammatory activation (CD80 and CD86) genes while downregulating tolerogenic genes (PD-L1 and PD-L2) in human monocyte-derived DCs (moDCs). These effects were reversed with oleic acid-enriched TRLs. Moreover, postprandial SFAs raised IL-12p70 levels, while TRL-MUFAs and TRL-PUFAs increased IL-10 levels in serum of healthy volunteers and in the medium of TRL-treated moDCs. In conclusion, postprandial TRLs are metabolic entities with DC-related tolerogenic activity, and this function is linked to the type of dietary fat in the meal. This study shows that the intake of meals enriched in MUFAs from olive oil, when compared with meals enriched in SFAs, prevents the postprandial production and priming of circulating pro-inflammatory DCs, and promotes tolerogenic response in healthy subjects. However, functional assays with moDCs generated in the presence of different fatty acids and T cells could increase the knowledge of postprandial TRLs’ effects on DC differentiation and function.

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Section: Introductionmentioning

confidence: 99%

Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation

et al. 2020

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Immediate-release niacin and a monounsaturated fatty acid-rich meal on postprandial inflammation and monocyte characteristics in men with metabolic syndrome

Montserrat-de la Paz,

del Carmen Naranjo,

Lopez

et al. 2023

Clinical Nutrition

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Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner

Toscano

Millán-Linares

Lemus-Conejo

et al. 2020

The Journal of Nutritional Biochemistry

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Effects of immediate‐release niacin and dietary fatty acids on acute insulin and lipid status in individuals with metabolic syndrome

Abstract: In the setting of niacin co-administration and compared to dietary SFAs, MUFAs limit the postprandial insulin, triglyceride and FFA excursions, and improve postprandial glucose homeostasis in MetS. © 2017 Society of Chemical Industry.

Cited by 7 publications

References 38 publications

Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation

Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation

Immediate-release niacin and a monounsaturated fatty acid-rich meal on postprandial inflammation and monocyte characteristics in men with metabolic syndrome

Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner

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