Adaptive and genetic evolution of Toxoplasma gondii: a host-parasite interaction

Silva, Rodrigo da; Langoni, Hélio; Megid, Jane

doi:10.1590/0037-8682-0251-2017

Cited by 1 publication

(1 citation statement)

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“…Moreover, toxoplasmosis in pregnant women can cause blindness, microcephaly, and mental retardation in the infant [6,12]. Different factors, such as host's (a) 3 Journal of Parasitology Research immune system status, genetic background, age, gender, contact with infected cats, environmental conditions, and diet and cultural habits, as well as the protozoan genotype, can affect the morbidity and mortality rate of Toxoplasma infection [13,14].…”

Section: Introductionmentioning

confidence: 99%

Immunoinformatic Analysis of Calcium-Dependent Protein Kinase 7 (CDPK7) Showed Potential Targets for Toxoplasma gondii Vaccine

Taghipour

Tavakoli

Sabaghan³

et al. 2021

Journal of Parasitology Research

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Apicomplexan parasites, including Toxoplasma gondii (T. gondii), express different types of calcium-dependent protein kinases (CDPKs), which perform a variety of functions, including attacking and exiting the host cells. In the current bioinformatics study, we have used several web servers to predict the basic features and specifications of the CDPK7 protein. The findings showed that CDPK7 protein has 2133 amino acid residues with an average molecular weight (MW) of 219085.79 D. The aliphatic index with 68.78 and grand average of hydropathicity (GRAVY) with -0.331 score were estimated. The outcomes of current research showed that the CDPK7 protein included 502 alpha-helix, 1311 random coils, and 320 extended strands with GOR4 method. Considering the Ramachandran plot, the favored region contains more than 92% of the amino acid residues. In addition, evaluation of antigenicity and allergenicity showed that CDPK7 protein has immunogenic and nonallergenic nature. The present research provides key data for more animal-model study on the CDPK7 protein to design an efficient vaccine against toxoplasmosis in the future.

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Section: Introductionmentioning

confidence: 99%