Adherence to ICRU-83 reporting recommendations is inadequate in prostate dosimetry studies

Mohan, Aishling; Forde, Elizabeth

doi:10.1016/j.prro.2017.08.006

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Another reason for the low RION incidence observed despite the high targeted dose delivered may be that the actual IMRT single-fraction dose to the NOS is usually lower than that of conventional radiotherapy. The OAR tolerance should be reconsidered when the fractionated dose or fractionation times of OARs are significantly reduced, which is different from the recommendations of the ICRU-83 report ( 37 ). Reduction of the single-fraction dose can be beneficial for NOS repair ( 38 ).…”

Section: Discussionmentioning

confidence: 87%

Loosening Neuro-Optic Structures Dosimetric Constraints Provides High 5-Year Local Recurrence-Free Survival With Acceptable Toxicity in T4 Nasopharyngeal Carcinoma Patients Treated With Intensity-Modulated Radiotherapy

Zhang

et al. 2021

Front. Oncol.

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ObjectiveWhether the original dosimetric constraints of neuro-optic structures (NOS) are appropriate for patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiotherapy (IMRT) remains controversial. The present study compared the survival rates and radiation-induced optic neuropathy (RION) occurrence between T4 NPC patients whose NOS were irradiated with a near maximum dose received by 2% of the volume (D2%) >55 Gy and ≤55 Gy. Moreover, the NOS dosimetric parameters and their correlation with RION occurrence were also evaluated.MethodsIn this retrospective study, 256 T4 NPC patients treated with IMRT between May 2009 and December 2013 were included. Patient characteristics, survival rates, dosimetric parameters, and RION incidence were compared between the D2% ≤55 Gy and D2% >55 Gy groups.ResultsThe median follow-up durations were 87 and 83 months for patients in the D2% >55 Gy and D2% ≤55 Gy groups, respectively. The 5-year local recurrence-free survival rates were 92.0 and 84.0% in the D2% >55 Gy and D2% ≤55 Gy groups (P = 0.043), respectively. There was no significant difference in the 5-year overall survival (OS) between both groups (D2% >55 Gy, 81.6%; D2% ≤55 Gy, 79.4%; P = 0.586). No patients developed severe RION (Grades 3–5), and there was no significant difference (P = 0.958) in the incidence of RION between the two groups. The maximum dose of NOS significantly affected the RION incidence, with a cutoff point of 70.77 Gy.ConclusionAppropriately loosening NOS dosimetric constraints in order to ensure a more sufficient dose to the target volume can provide a better 5-year local recurrence-free survival and acceptable neuro-optic toxicity in T4 NPC patients undergoing IMRT.

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Section: Discussionmentioning

confidence: 87%

Loosening Neuro-Optic Structures Dosimetric Constraints Provides High 5-Year Local Recurrence-Free Survival With Acceptable Toxicity in T4 Nasopharyngeal Carcinoma Patients Treated With Intensity-Modulated Radiotherapy

Zhang

et al. 2021

Front. Oncol.

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“…Therefore, ICRU 83 states D 50% to be the true replacement of the former ICRU reference point. For the same reason, some authors recommend D 50% as the value of dose prescription . In terms of prescription, however, the authors of the ICRU 83 report respect the freedom to prescribe to any value, for example, “(…) if a radiation oncologist concludes that a larger fractional V than 50% is biologically relevant”.…”

Section: Technical Principles and Definitions Of Terms In Imrtmentioning

confidence: 99%

Intensity‐modulated radiation therapy dose prescription and reporting: Sum and substance of the International Commission on Radiation Units and Measurements Report 83 for veterinary medicine

Bley

Meier

Besserer

et al. 2019

Vet Radiology Ultrasound

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Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. In spite of this framework, however, in implementing IMRT, we have identified different "interpretations" of the extended prescription and reporting recommendations of the International Commission on Radiation Units and Measurements (ICRU 83), even within our small team. In the following commentary review, we provide a short summary of various detailed aspects of the ICRU 83 recommended (IMRT) prescription and reporting, including (a) absorbed target dose specification and prescription, (b) homogeneity and conformity, and (c) reporting of absorbed dose in organs at risk. In particular, we want to share our thoughts on possible dangers of noncompliance in adhering to protocol, prescription, and reporting. As veterinary IMRT publications still sparsely adhere to the recommendations of the ICRU, we were motivated to summarize the recommendations to facilitate appropriate reporting for IMRT in future veterinary studies. K E Y W O R D SIMRT, normalization, treatment planning, veterinary

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Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study

Das

Yadav

Andersen

et al. 2023

Radiotherapy and Oncology

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Adherence to ICRU-83 reporting recommendations is inadequate in prostate dosimetry studies

Cited by 4 publications

References 22 publications

Loosening Neuro-Optic Structures Dosimetric Constraints Provides High 5-Year Local Recurrence-Free Survival With Acceptable Toxicity in T4 Nasopharyngeal Carcinoma Patients Treated With Intensity-Modulated Radiotherapy

Loosening Neuro-Optic Structures Dosimetric Constraints Provides High 5-Year Local Recurrence-Free Survival With Acceptable Toxicity in T4 Nasopharyngeal Carcinoma Patients Treated With Intensity-Modulated Radiotherapy

Intensity‐modulated radiation therapy dose prescription and reporting: Sum and substance of the International Commission on Radiation Units and Measurements Report 83 for veterinary medicine

Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study

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