Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands

Dong, Fei; Call, Mindy K.; Xia, Ying; Kao, Winston W.‐Y.

doi:10.1016/j.exer.2017.04.006

Cited by 16 publications

(7 citation statements)

References 47 publications

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“…The curved whiskers, wavy fur, and inflamed Meibomian glands in adult mice are consistent with a reduction in ADAM17/TGFα/EGFR signaling ( 45 , 60 , 61 ), which presumably also explains the inflammation of Zymbal glands. With respect to the curvy whiskers and wavy fur, the Adam17Δcyto mice resemble other mice with hypomorphic mutations in the ADAM17/EGFR pathways ( 16 , 44 , 45 ).…”

Section: Discussionmentioning

confidence: 54%

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

Lora

Weskamp

et al. 2021

Journal of Biological Chemistry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionmentioning

confidence: 54%

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

Lora

Weskamp

et al. 2021

Journal of Biological Chemistry

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“…EGF was considered associated with various ophthalmological diseases. 32–34 A previous study showed there is association between IL1A polymorphisms and primary open angle glaucoma. 35 CD40 and CD40LG were considered associated with pathogenesis of thyroid eye disease.…”

Section: Discussionmentioning

confidence: 98%

Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia

Lai¹,

Wu²,

Liang³

2022

IJGM

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Aim High myopia (HM) is a global problem; however, the molecular pathogenesis of HM underlying lens remains largely unknown. The aims of the present study were to identify the potential key genes and pathways involved in lens changes of HM. Methods Gene set enrichment analysis was carried out to identify the HM-specific pathway gene sets. The differentially expressed genes (DEGs) in lens epithelia of HM eyes compared to emmetropic control were screened using limma R package. A DEG-based protein–protein interaction network was constructed and used to identify hub genes and gene cluster analysis. The functional enrichment analysis was performed to reveal the potential biological functions for each gene cluster. Results Multiple metabolism-related pathways were significantly enriched in lens epithelia of HM. The expression patterns of DEGs could accurately distinguish HM and emmetropic and CD34, CD40, EGF, IL1A, CD40LG, and CXCL12 maybe the potential key genes involved in HM. Three gene clusters were identified and involved in distinct pathways. MAPK signaling pathway and calcium signaling pathway were considered the key pathways involved in lens changes of HM, due to two gene clusters both involve in these two pathways. Conclusion We identified potential key genes in pathological lens growth of HM eyes and proposed that the imbalances of MAPK signaling pathway and calcium signaling pathway may be the two crucial steps of pathological lens growth in HM.

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“…It is expressed in human meibomian gland epithelial cells as well, and its signaling increases the proliferation but not the differentiation [ 12 ]. EGFR activation promotes proliferation and inhibits differentiation of meibomian gland epithelial cells, and decreases processes related to fatty acid metabolism [ 13 ]. The HER2 receptor is the 2nd member of the EGFR family and can be involved in the regulation of epithelial cells; it may control cell growth, differentiation, or apoptosis (lateral signal transduction) [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…EGFR activation promotes proliferation and inhibits differentiation of meibomian gland epithelial cells, and decreases processes related to fatty acid metabolism [ 13 ]. The HER2 receptor is the 2nd member of the EGFR family and can be involved in the regulation of epithelial cells; it may control cell growth, differentiation, or apoptosis (lateral signal transduction) [ 13 ]. HER2-inhibitors (HER, PER) get cells arrested in the G1 phase; therefore, survival and angiogenesis is suppressed.…”

Section: Discussionmentioning

confidence: 99%

Novel Meibomian Gland and Tarsal Conjunctival Changes Associated with Trastuzumab, Pertuzumab, and Anastrozole Treatment for Metastatic HER2 Positive Breast Cancer: A Case Report and Literature Review

et al. 2022

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The aim of the study was to report a case of severe meibomian gland dysfunction (MGD) and conjunctival changes associated with trastuzumab, pertuzumab, and anastrozole therapy in a HER-2 positive breast cancer patient. A 57-year-old white woman was treated with trastuzumab and pertuzumab biological and anastrozole endocrine therapy for metastatic breast cancer for several months. She suffered from intense eye pain and foreign body sensation. On the ocular surface, severe MGD developed without corneal lesions. On the tarsal conjunctiva, circumscribed lesions evolved 6 months after receiving anticancer therapy. After biopsy, the histological assessment excluded metastasis or chalazion. The lesion consisted of subepithelial lymphocytic infiltrates surrounding lipid-laden CD68-positive macrophages. Besides the redundant lipid accumulation, no acute necrotic reaction was seen. Noncontact infrared meibography visualized ductal drop-out in the upper and lower lids, and functional tests confirmed severe MGD. During the 18-month follow-up, the patient received treatment for MGD and no new conjunctival lesions developed, subjective symptoms subsided, and ocular surface morphology remained unchanged. The novel HER2-inhibitor trastuzumab and pertuzumab biological therapy and anastrozole endocrine therapy were associated with the disruption of the ocular surface milieu. The new histological aspect of tarsal conjunctiva changes may give a hint to understand the potential underlying molecular mechanisms of anticancer therapy-associated severe MGD. Since anticancer therapies may substantially interfere with the ocular surface milieu, awareness of this side effect leads to improved care of oncology patients.

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Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands

Cited by 16 publications

References 47 publications

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia

Novel Meibomian Gland and Tarsal Conjunctival Changes Associated with Trastuzumab, Pertuzumab, and Anastrozole Treatment for Metastatic HER2 Positive Breast Cancer: A Case Report and Literature Review

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