Protective effect of xanthohumol against age-related brain damage

Rancán, Lisa; Paredes, Sergio D.; García, Irene; Muñoz, Pedro; Garcı́a, Cruz; Hontanar, Guzmán López de; Fuente, Mónica De la; Vara, Elena; Tresguerres, Jesús A.F.

doi:10.1016/j.jnutbio.2017.07.011

Cited by 41 publications

(24 citation statements)

References 50 publications

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“…High amount of neuroinflammation could have hazardous effects on synaptic proteins and other proteins. The increased neuroinflammation in old animals has also been shown in other studies (Buchanan et al 2008;Rancán et al 2017;Zhao et al 2018). In general, in the brain, neuronal inflammation and oxidative stress are related to each other (Durany et al 1999;Floyd and Hensley 2002).…”

Section: Discussionsupporting

confidence: 72%

“…During aging process, the expression of synaptic proteins decreases. The number of small synapse expressing PSD-95 (Ma et al 2014;Xu et al 2018) and the expression of SYP (Rancán et al 2017;Ma et al 2019) were reduced. In another study it has been shown that there was a decline in synaptophysin expression in old human subjects (Hatanpää et al 1999).…”

Section: Discussionmentioning

confidence: 96%

“…In fact, aging is considered to be an important risk factor for various pathological conditions, including impaired behavioral performance, memory and cognition (Petersen 2004). Many studies suggest that the development of these pathologies may be affected by changes in expression of inflammatory markers (Rancán et al 2017), increase in oxidative stress (Dröge and Schipper 2007) and reduction in synaptic plasticity (Bishop et al 2010).…”

Section: Discussionmentioning

confidence: 99%

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The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice

Keser¹,

Dogramaci²,

Şahin³

et al. 2020

gpb

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7,8-Dihydroxyflavone (7,8-DHF) is a natural flavonoid compound that act as Trk-B agonist. 7,8-DHF is also a potent antioxidant. When applied systematically, 7,8-DHF can pass through bloodbrain barrier and exhibit potential therapeutic effects in several animal models of neurodegenerative disorders. This study investigates the remedial effects of 7,8-DHF on behavioral impairments and biochemical changes associated with aging with a species emphasis on cortex. For this purpose three experimental groups were formed which are young control group, old group and old-DHF groups. 5 mg/kg 7,8-DHF was administered intraperitoneally to old-DHF group for 3 weeks. We assessed the hang wire and adhesive removal performances of mice. Also, oxidative stress, neuroinflammation and synaptic protein levels in the cortex were measured. We observed that chronic administration of 7,8-DHF improved behavioral performance of old mice. Besides, 7,8-DHF reversed MDA level which was increased in old control animals. However, 3 weeks application of 7,8-DHF failed to recover the levels of neuroinflammation markers (TNF-α and IL-6) and synaptic proteins (PSD-95 and Synaptophysin) which were reduced in old group. These findings demonstrate that improvement of age-dependent behavioral impairments and MDA levels by 7,8-DHF could be attributed to its antioxidant actions.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice

Keser¹,

Dogramaci²,

Şahin³

et al. 2020

gpb

View full text Add to dashboard Cite

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“…Other bioactivities attributed to hop components include neuroprotective, antidiabetic, and cardioprotective effects. Xanthohumol promoted neuronal recovery in rats with intracerebral hemorrhage [71], and it also showed a protective effect on the brain damage induced by aging [72]. This compound also has the ability to inhibit adipogenesis so it can be used in the prevention of obesity.…”

Section: Other Biological Activitiesmentioning

confidence: 99%

Humulus lupulus L. as a Natural Source of Functional Biomolecules

Astray

Gullón

et al. 2020

Applied Sciences

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Hops (Humulus lupulus L.) are used traditionally in the brewing industry to confer bitterness, aroma, and flavor to beer. However, in recent years, it has been reported that female inflorescences contain a huge variety of bioactive compounds. Due to the growing interest of the consumers by natural ingredients, intense research has been carried out in the last years to find new sources of functional molecules. This review collects the works about the bioactive potential of hops with applications in the food, pharmaceutical, or cosmetic industries. Moreover, an overview of the main extraction technologies to recover biomolecules from hops is shown. Bioactivities of hop extracts such as antibacterial, antifungal, cardioprotective, antioxidant, anti-inflammatory, anticarcinogenic, and antiviral are also summarized. It can be concluded that hops present a high potential of bioactive ingredients with high quality that can be used as preservative agents in fresh foods, extending their shelf life, and they can be incorporated in cosmetic formulation for skincare as well.

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“…The iso-α-acids, as agonists of peroxisome proliferator-activated receptor gamma (PPAR-γ), increase microglia phagocytosis of Aβ and suppress inflammation in neuronal tissue [147]. Xanthohumol has been defined as a very important compound of hops and beer due to its positive effects as an antioxidant and neuroprotective described in some central papers [148]. In this line, Huang et al [137] found several metabolic pathways where prenylflavonoid xantuhumol can be engaged as protective in some neurodegenerative diseases, such as Alzheimer's (e.g.…”

Section: Hops (Humulus Lupulus L)mentioning

confidence: 99%

The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer’s Disease

et al. 2019

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The prevalence of degenerative diseases has risen in western countries. Growing evidence suggests that demenia and other cognition affectations are associated with ambient factors including specific nutrients, food ingredients or specific dietary patterns. Mediterranean diet adherence has been associated with various health benefits and decreased risk of many diseases, including neurodegenerative disorders. Beer, as part of this protective diet, contains compounds such as silicon and hops that could play a major role in preventing brain disorders. In this review, different topics regarding Mediterranean diet, beer and the consumption of their main compounds and their relation to neurological health have been addressed. Taking into account published results from our group and other studies, the hypothesis linking aluminum intoxication with dementia and/or Alzheimer’s disease and the potential role of regular beer has also been considered. Beer, in spite of its alcohol content, may have some health benefits; nonetheless, its consumption is not adequate for all subjects. Thus, this review analyzed some promising results of non-alcoholic beer on several mechanisms engaged in neurodegeneration such as inflammation, oxidation, and cholinesterase activity, and their contribution to the behavioral modifications induced by aluminum intoxication. The review ends by giving conclusions and suggesting future topics of research related to moderate beer consumption and/or the consumption of its major compounds as a potential instrument for protecting against neurodegenerative disease progression and the need to develop nutrigenetic and nutrigenomic studies in aged people and animal models.

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Protective effect of xanthohumol against age-related brain damage

Cited by 41 publications

References 50 publications

The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice

The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice

Humulus lupulus L. as a Natural Source of Functional Biomolecules

The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer’s Disease

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