CranFlow: An Application for Record‐Taking and Management Through the Brazilian Database on Craniofacial Anomalies

Abstract

The identification of risk factors, consistent genetic approach associated with clinical data and follow-up result in valuable information to develop and improve personalized treatment and studies on genotype-phenotype correlation. Adoption of CranFlow in different clinical services may support comparison between populations. This application has the potential to contribute to improvements in healthcare, quality of services, clinical and surgical outcomes, and the standard of living of individuals with craniofacial anomalies. Birth Defects Research 110:72-80, 2018. © 2017 Wiley Periodicals, Inc.

Testing criteria for 22q11.2 deletion syndrome: preliminary results of a low cost strategy for public health

“…In addition, this study has another differential that can aggregate in clinical practice and in public health, which is the introduction of an online tool - CranFlow , which standardizes the data collection according to those criteria, as well as facilitates their summation by groups and columns for each consultation, since it is performed automatically in each evaluation [24].…”

“…Standardized clinical and complementary data were collected through a web-based application ( CranFlow : Craniofacial anomalies: registration, flow, and management) [24]. It was developed by this research group for general craniofacial anomalies with a specific area for 22q11.2DS suspicion, in which data are recorded and the sum of features is automatically performed according to the proposed criteria by Monteiro [22].…”

Brazil's Craniofacial Project: Different approaches on orofacial clefts and 22q11.2 deletion syndrome

“…This is a universal problem that mainly affects large samples and must be addressed. In our experience with maintaining the BDCA, CranFlow has strengthened the quality of dysmorphic data, enabling standardized record taking through a refined clinical assessment (Volpe-Aquino et al, 2018). All the cases are assessed by trained geneticists to make use of CranFlow, and dysmorphic signs are coded by the Human Phenotype Ontology (Köhler et al, 2019).…”

“…This extensive and updated database was renamed as the Brazilian Database on Craniofacial Anomalies (BDCA). Moreover, we also developed CranFlow—Craniofacial Anomalies: Registration, Flow, and Management—to replace paper‐based forms (Volpe‐Aquino et al, 2018). CranFlow is a web‐based application that continuously feeds the BDAC.…”

“…Genetic tests (karyotype, fluorescence in situ hybridization [FISH]; multiplex ligation‐dependent probe amplification [MLPA]; chromosomal microarray analysis [CMA]; Sanger sequencing; and next‐generation sequencing [NGS]) are performed through research projects, and findings of medical relevance are fed back into the BDCA via CranFlow for the purpose of counseling provided by the collaboration of local geneticists (Volpe‐Aquino et al, 2018).…”