Effect of clonidine on the efficacy of lignocaine local anesthesia in dentistry: A systematic review and meta‐analysis of randomized, controlled trials

Abstract

Alternatives to adrenaline with lignocaine local anesthesia, such as clonidine, have been trialed in various randomized, controlled trials. Therefore, the aim of the present systematic review was to compile the available evidence on using clonidine with lignocaine for dental anesthesia. Electronic databases were searched for eligible studies. A data-extraction form was created, extracted data were analyzed using non-Cochrane mode in RevMan 5.3 software. Heterogeneity between the studies were assessed using the forest plot, I statistics (where >50% was considered to have moderate-to-severe heterogeneity), and χ -test. Random-effects models were used because of moderate heterogeneity. Five studies were included for the final review. While clonidine was found to significantly shorten the onset of local anesthesia when measured subjectively, no significant difference was observed objectively. No significant difference was observed in the duration and postoperative analgesia. Stable hemodynamic parameters within the safe range were observed postoperatively when clonidine was used. Clonidine could be considered as an alternative to adrenaline in cases of contraindications to adrenaline, such as like cardiac abnormalities, hypertension, and diabetes.

Eficacia anestésica del bloqueo del nervio dentario inferior en molares con pulpitis: una revisión sistemática tipo paraguas

“…Después de leer el texto completo, se excluyeron doce revisiones por las siguientes razones: Evaluación solo de la efectividad de premedicación analgésica (Nagendrababu al. 2018 (5) , Zanjir et al 2019 (7) , Pulikkotil et al 2018 (8) , Shirvani et al 2017 (9) , Karapinar et al 2019 (10) , Lapidus et al 2016 (11) , Corbella et al 2017 (12) , Larocca et al 2019 (13) , Sivaramakrishnan et al 2017 (14) , Sivaramakrishnan et al 2018 (15) . Inclusión de estudios que involucraban otras técnicas de abordaje anestésico (Dianat et al 2020 (16) , Nagendrababu et al 2019 (17) .…”

The additive effect of clonidine to lidocaine on postoperative pain management after root canal treatment on mandibular molars with symptomatic irreversible pulpitis: A prospective randomised double-blind clinical trial

“…Clonidine may produce some systemic side effects. [ 19 20 ] However, these side effects are directly correlated to its concentrations. Brkovic et al .…”