Prognostic value of E2F1 in rectal cancer

Uzer, Hasan; Sözüer, Erdoğan; Akçan, Alper; Öz, Bahadır

doi:10.5152/turkjsurg.2017.3576

Turk J Surg

2017

DOI: 10.5152/turkjsurg.2017.3576

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Prognostic value of E2F1 in rectal cancer

Hasan Uzer

Erdoğan Sözüer

Alper Akçan

et al.

Abstract: The survival rates are higher in rectal cancer patients with strong immunohistochemical nuclear staining of E2F transcription factor 1.

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2023

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Studying Adenomatous Polyposis Coli (APC) gene at colorectal cancer patients. The roleof E2F transcription factor 1 (E2F1), tumor suppressor P14 (ARF) and marker ofproliferation Ki-67

Loutas,

Boki,

Tairis

et al. 2023

Prog Health Sci

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Purpose: The purpose of this study is to determinethe relationship between APC gene mutations andsubcellular differentiation levels of E2F1, P14ARFand KI67 proteins. Furthermore, if such connectionscan be used in the area of preventive health care.Materials and methods: The 30 hoursImmunohistochemistry protocol used, had samplespreparation, antigen retrieval, background blocking,target detection and sample visualization. Sampleswere viewed and captured by light microscopy.Results: The conducted research concern 88 patientswith a range age of 56 years. 57,7% had no tobaccoaddiction, 3,84% were obese and 19,23% had thetendency to consume alcohol. About 31% had atleast one family member with a history of cancer.Intensity and positivity of the genes vary as seen intables.Conclusions: By targeting specific andsimultaneously multiple pathways based onmolecular signatures, enables cases to be detected atan earlier stage, when there are greater chances ofcure as treatment is more effective. A plan for earlydetection of cancer is a key component within anoverall cancer control plan. An early diagnosisprogram is far more cheap and easy leading toappropriate treatments which finally reduce deathrates and suffering due to cancer

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Studying Adenomatous Polyposis Coli (APC) gene at colorectal cancer patients. The roleof E2F transcription factor 1 (E2F1), tumor suppressor P14 (ARF) and marker ofproliferation Ki-67

Loutas,

Boki,

Tairis

et al. 2023

Prog Health Sci

View full text Add to dashboard Cite

show abstract

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Prognostic value of E2F1 in rectal cancer

Abstract: The survival rates are higher in rectal cancer patients with strong immunohistochemical nuclear staining of E2F transcription factor 1.

Cited by 1 publication

References 23 publications

Studying Adenomatous Polyposis Coli (APC) gene at colorectal cancer patients. The roleof E2F transcription factor 1 (E2F1), tumor suppressor P14 (ARF) and marker ofproliferation Ki-67

Studying Adenomatous Polyposis Coli (APC) gene at colorectal cancer patients. The roleof E2F transcription factor 1 (E2F1), tumor suppressor P14 (ARF) and marker ofproliferation Ki-67

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