Weekly oral bisphosphonates over 2 years prevent bone loss in cardiac transplant patients

Lange, U.; Classen, Katharina; Müller‐Ladner, Ulf; Richter, Manfred

doi:10.1111/ctr.13122

Cited by 9 publications

(2 citation statements)

References 19 publications

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“…Therefore, these drugs are not suitable for long-term use for the treatment of bone-damaging diseases, and they may not be suitable as oral drugs either. In addition, long-term medication can cause problems such as gastrointestinal (GI) toxicity, weight loss, bone pain, low calcium levels ( Lu et al, 2016 ; Gao et al, 2017 ; Grigg et al, 2017 ; Lange et al, 2017 ; Monda et al, 2017 ). Hence, potential new drugs are urgently needed to replace existing treatment strategies due to clinically adverse effects ( Estell and Rosen, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Li²,

Li³

et al. 2022

Front. Pharmacol.

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Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts. If this balance is broken, it will lead to bone mass loss, bone density reduction, and bone metabolic diseases, such as osteoporosis. Polyphenols in Chinese herbal medicines are active ingredients in plant extracts with high safety and few side effects, and they can play a role in affecting bone formation and bone resorption. Some of these have estrogen-like effects and can better target bone health in postmenopausal women. The purpose of this review is to provide comprehensive information on the mechanisms underlying the relationship between traditional Chinese medicine polyphenols and bone formation or bone resorption.

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Section: Introductionmentioning

confidence: 99%

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Li²,

Li³

et al. 2022

Front. Pharmacol.

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“…The drugs for treatment of osteoporosis include bisphosphonates, parathyroid hormones, and hormone replacement therapy; however, the side effects of these drugs could increase the risk of cancer, stroke, and heart attack [6][7][8] . Thus, adopting a new treatment to reduce fracture risks for this disease is vitally important.…”

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confidence: 99%

Effects of Acupoint Application Therapy with TianGui Powder on Osteoporosis in Ovariectomized Rats through TGF‐β1 and Smad2/3 Signaling Pathway

Lin

Wang

Zhang

et al. 2019

Orthopaedic Surgery

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Objectives To explore the effects of acupoint application therapy (AAT) with TianGui Powder (TGP) on the expressions of the transforming growth factor β1 (TGF‐β1) and Smad‐2/3 signaling pathway in ovariectomized osteoporosis rats. Methods Sixty rats were randomly divided into four groups: normal group (group A), model group (group B), TGP group (group C), and Western medicine group (group D). Group A had only the corresponding amount of adipose tissue around the ovary removed; rats in the other groups had bilateral ovariectomies. After 1 week, groups A and B were given 1 mL/100 mg normal saline solution by gavage, group C was treated with AAT with TGP on ShenQue acupoint (0.2 piece/rat, 6 h/time, 1 time/d) and group D was given calcium carbonate vitamin D3 (36 mg/kg/d) and alfacalcidol (0.05 μg/kg/d) tablet suspension. In this study, the bone mineral density (BMD) , the levels of BALP, TRAP‐5b, and BGP in serum and the changes in bone histomorphology was detected. For acquiring lumbar experimental data, the expression of TGF‐β1, Smad‐2/3 proteins and mRNA of TGF‐β1and Smad‐2/3 were assessed. After 12 weeks, the data were collected for analysis. Results Compared with group A, the bone trabecula was thinner and significantly reduced in other groups. The result of BMD improved significantly in both groups C and D compared to group B after intervention ( P < 0.05). In contrast, compared to group B, the levels of BALP, TRAP‐5b, and BGP significantly declined in both groups C and D. In group C, the results of protein expressions in TGF‐β1, Smad‐2/3 were 2.870 ± 0.270, 1.552 ± 0.111, and 1.420 ± 0.079, respectively. In groups C and D, those indications significantly declined compared to group B ( P < 0.01). In group C, the level of mRNA expressions of TGF‐β1, Smad‐2/3 were 1.872 ± 0.177, 1.672 ± 0.086, and 1.790 ± 0.136, respectively. Compared with group B, those indications had significant difference in groups C and D ( P < 0.05). Conclusion Acupoint application therapy with TGP could significantly improve the BMD. The TGF‐β1 and Smad‐2/3 signaling pathway could be a therapeutic target of TGP in postmenopausal osteoporosis rats.

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Dietary nutraceuticals as backbone for bone health

Pandey

Gupta

Karelia

et al. 2018

Biotechnology Advances

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Weekly oral bisphosphonates over 2 years prevent bone loss in cardiac transplant patients

Cited by 9 publications

References 19 publications

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Effects of Acupoint Application Therapy with TianGui Powder on Osteoporosis in Ovariectomized Rats through TGF‐β1 and Smad2/3 Signaling Pathway

Dietary nutraceuticals as backbone for bone health

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