Hyperosmolarity evokes histamine release from ileum mucosa by stimulating a cholinergic pathway

Wang, Banqin; An, Ning; Shaikh, Abdul Sami; Wang, Haoyi; Xiao, Ling; Liu, Hongwei; Li, Jingxin; Zhao, Dongbo

doi:10.1016/j.bbrc.2017.09.093

Cited by 2 publications

(2 citation statements)

References 23 publications

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“… 54 The unabsorbed substance, such as LAC, also induced a decrease in rat ileum to short-circuit currents by bringing out histamine discharge from ileum mucosa. 55 SM inhibits the dose-dependent manner of neutrophil-mediated histamine release. 56 The degree of nitrate and inducible nitric oxide synthase (iNOS) significantly increases in cirrhotic patients.…”

Section: Discussionmentioning

confidence: 92%

The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats

et al. 2020

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Introduction: Chronic liver disease frequently accompanied by hepatic encephalopathy (HE). Changes in the permeability of the blood-brain barrier in HE, make an easier entrance of ammonia among other substances to the brain, which leads to neurotransmitter disturbances. Lactulose (LAC), causes better defecation and makes ammonia outreach of blood. Silymarin (SM) is a known standard drug for liver illnesses. The purpose of this research was to determine the results of LAC and SM combined treatment, on the changes in memory of cirrhotic male rats. Methods: The cirrhotic model established by treatment with thioacetamide (TAA) for 18 weeks. Cirrhotic rats randomized to four groups (n = 7): TAA group (received drinking water), LAC group (2 g/kg/d LAC in drinking water), SM group (50 mg/kg/d SM by food), SM+ LAC group (similar combined doses of both compounds) for 8 weeks. The control group received drinking water. The behavior examined by wire hanging (WH), passive avoidance (PA), and open field (OF) tests. Results: Our findings showed that treatment with SM+LAC effectively increased PA latency, compared with the control group. The results showed that the administration of LAC and SM+LAC affected the number of lines crossed, the total distance moved and velocity in the OF tests. Conclusion: SM and LAC have anti-inflammatory effects that are memory changing. It may be due to their useful effects. These results indicated that SM+LAC restored memory disturbance and irritated mood in the cirrhotic rats. Comparable neuroprotection was never previously informed. Such outcomes are extremely promising and indicate the further study of SM+LAC.

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Section: Discussionmentioning

confidence: 92%

The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats

et al. 2020

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“…However, the new role of AGR2 in liver and intestinal fatty acid uptake and activation promoted AGR2-mediated lipid accumulation, indicating that AGR2 was an important regulator of systemic lipid metabolism, and downregulation of AGR2 might counteract the development of obesity (20). The IBF depended on intestinal permeability (21). This study evaluated the Isc, Gt, and EB contents of colon and small intestine tissues respectively, which could form a more comprehensive evaluation advantage.…”

Section: Discussionmentioning

confidence: 99%

The relationship between AGR2 levels and intestinal barrier function in high-fat diet animal models

Facai Kang,

Shuhong Zhao,

Huimin Ren

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Hyperosmolarity evokes histamine release from ileum mucosa by stimulating a cholinergic pathway

Cited by 2 publications

References 23 publications

The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats

The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats

The relationship between AGR2 levels and intestinal barrier function in high-fat diet animal models

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