The predictive value of plasma cytokines on gastroesophageal anastomotic leakage at an early stage in patients undergoing esophagectomy

Song, Jieqiong; He, Yizhou Joseph; Fang, Yuan; Wu, Wei; Zhong, Ming

doi:10.21037/jtd.2017.07.32

Cited by 7 publications

(11 citation statements)

References 19 publications

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“…Study characteristics of the included studies are shown in Table 1. The role of systemic biomarkers was evaluated separately in fifteen studies, [32,33,34,35,36,37,38,39,40,41,42,43,44,45,46] drain fluid in nine [33,44,45,46,47,48,49,50,51], combined scoring systems in three studies [35,41,52], and mediastinal microdialysis [53], urine volatile organic compounds [54] and respiratory index [40] were all evaluated in one study. All studies except three [37,53,54] were retrospective.…”

Section: Resultsmentioning

confidence: 99%

“…All studies included operations for upper gastrointestinal cancer. Only ten studies reported on the rate of elective surgery, in which it was mostly 100 per cent elective [32,35,36,37,43,47,48,53,54] except for Dutta and colleagues in which surgeries were 97% elective [34]. While some studies completely or partially operated through a minimally invasive approach, the majority of the resections were performed through an open approach.…”

Section: Resultsmentioning

confidence: 99%

“…Various definitions of AL were found in the included studies, as shown in Table 2. Six studies [40,42,43,45,49,50] did not mention the median or range concerning the day of AL diagnosis. In the remaining eighteen studies AL was diagnosed with a median on POD 7, ranging between 1 and 30 days.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies [32,33,34,35,36,37,39,40,41,42,43,44,45] evaluated fourteen different inflammatory biomarkers for detecting AL, namely CRP, leucocytes, procalcitonin (PCT), albumin, prealbumin, per centage of neutrophils, fibrinogen levels, urinary volatile organic compounds (VOCs), interleukin (IL) 2R, IL-6, IL-8, IL-10, tumor necrosis factor (TNF) α and blood G antigenemia (BG).…”

Section: Resultsmentioning

confidence: 99%

“…Cytokines were evaluated by Song and colleagues [43], with a total of 183 patients—of whom, 16 developed AL. Cytokine levels of interleukin (IL)-2R, -6, -8, -10 and TNF-α were measured on POD 1.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Systematic Review of the Role of Biomarkers in Predicting Anastomotic Leakage Following Gastroesophageal Cancer Surgery

Mooij

Brink

Merry

et al. 2019

JCM

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Anastomotic leakage (AL) following gastroesophageal cancer surgery remains a serious postoperative complication. This systematic review aims to provide an overview of investigated biomarkers for the early detection of AL following esophagectomy, esophagogastrectomy and gastrectomy. All published studies evaluating the diagnostic accuracy of biomarkers predicting AL following gastroesophageal resection for cancer were included. The Embase, Medline, Cochrane Library, PubMed and Web of Science databases were searched. Risk of bias and applicability were assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) 2 tool. Twenty-four studies evaluated biomarkers in the context of AL following gastroesophageal cancer surgery. Biomarkers were derived from the systemic circulation, mediastinal and peritoneal drains, urine and mediastinal microdialysis. The most commonly evaluated serum biomarkers were C-reactive protein and leucocytes. Both proved to be useful markers for excluding AL owing to its high specificity and negative predictive values. Amylase was the most commonly evaluated peritoneal drain biomarker and significantly elevated levels can predict AL in the early postoperative period. The associated area under the receiver operating characteristic (AUROC) curve values ranged from 0.482 to 0.994. Current biomarkers are poor predictors of AL after gastroesophageal cancer surgery owing to insufficient sensitivity and positive predictive value. Further research is needed to identify better diagnostic tools to predict AL.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Systematic Review of the Role of Biomarkers in Predicting Anastomotic Leakage Following Gastroesophageal Cancer Surgery

Mooij

Brink

Merry

et al. 2019

JCM

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Cytokine Response in the Pleural Fluid and Blood in Minimally Invasive and Open Esophagectomy

et al. 2019

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Background Transthoracic esophagectomy for cancer triggers a massive inflammatory reaction. The data whether a minimally invasive esophagectomy (MIE) leads to less pronounced inflammatory response compared to open rightsided transthoracic esophagectomy (OE) are scarce. The aim of this study was to evaluate the extent of the inflammatory reaction, represented by levels of the pro-inflammatory interleukins IL-6 and IL-8, the anti-inflammatory IL-1 RA and the chemokines CINC-1 and MCP-1 in the right pleural fluid and the blood from patients undergoing standard OE or MIE. Methods Pleural drainage fluid and blood was collected at five different time points during the first 72 h following surgery, and the concentrations of IL-6, IL-8, IL-1 RA, CINC-1 and MCP-1 were analyzed using enzyme-linked immune-sorbent assays in 24 patients undergoing MIE or OE. Results The groups were matched for cancer stage and comorbidities. Pro-and anti-inflammatory mediator levels in the pleural fluid were markedly increased at the end of surgery and on postoperative days 1-3. The pleural inflammatory response of all cyto-and chemokines was lower in the MIE group, reaching significance at some time points. Cyto-and chemokine response levels measured in the blood were overall lower compared to those in the pleural fluid. The chemokines CINC-1 and MCP-1 reacted less pronounced or not at all. Preoperative pulmonary comorbidity, postoperative pulmonary morbidity and length of surgery were associated with an increased reaction in selected mediators. Conclusions The minimally invasive technique attenuates the inflammatory response, especially locally in the thoracic compartment. Length of procedure, preoperative pulmonary comorbidity and postoperative pulmonary complications are mirrored in an increase in individual inflammatory markers in the pleural fluid. The value of the chemokines CINC-1 and MCP-1 as markers of inflammation in the setting of esophagectomy is unclear.

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Role of Interleukin-6 in Prediction of Early Complications After Minimally Invasive Oesophagectomy—a Pilot Study

Kumarasamy

Kumar

Sharma

et al. 2023

Indian J Surg Oncol

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The predictive value of plasma cytokines on gastroesophageal anastomotic leakage at an early stage in patients undergoing esophagectomy

Cited by 7 publications

References 19 publications

Systematic Review of the Role of Biomarkers in Predicting Anastomotic Leakage Following Gastroesophageal Cancer Surgery

Systematic Review of the Role of Biomarkers in Predicting Anastomotic Leakage Following Gastroesophageal Cancer Surgery

Cytokine Response in the Pleural Fluid and Blood in Minimally Invasive and Open Esophagectomy

Role of Interleukin-6 in Prediction of Early Complications After Minimally Invasive Oesophagectomy—a Pilot Study

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