Fluorescence‐Guided Surgery in the Combined Treatment of Peritoneal Carcinomatosis from Colorectal Cancer: Preliminary Results and Considerations

Lieto, Eva; Auricchio, A; Cardella, Francesca; Mabilia, Andrea; Basile, Nicoletta; Castellano, Paolo; Orditura, Michele; Galizia, Gennaro

doi:10.1007/s00268-017-4237-7

Cited by 43 publications

(34 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some researchers chose 24 hours after ICG injection to perform the NIF imaging guided surgery . Whereas some studies suggested other time points . For example, in head and neck cancer, Yokoyama et al suggested that the optimal timing for tumor visibility was 30 minutes to 2 hours after ICG injection.…”

Section: Discussionmentioning

confidence: 99%

“…25,33 Whereas some studies suggested other time points. [34][35][36] For example, in head and neck cancer, Yokoyama et al 18 suggested that the optimal timing for tumor visibility was 30 minutes to 2 hours after ICG injection. However, the optimal surgical time mentioned above was determined only by surgeon's vision, and might vary with different surgeons.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

et al. 2018

View full text Add to dashboard Cite

Background The study aimed to define indocyanine green (ICG) kinetics to determine the optimal ICG dose and surgical time for near‐infrared fluorescence‐guided oral cancer surgery. Methods Spectrometer and grayscale digital imaging were used to quantify the ICG kinetics in 12 patients with oral cancer. The fluorescence intensity and signal‐to‐background ratio (SBR) of tumor and normal tissue were tested at 1, 6, and 24 hours after ICG injection. Results The greatest contrast in the fluorescence intensity between tumor and normal tissue was observed at 6 hours (P < .01), and of three dose groups (0.5, 0.75, and 1.0 mg/kg), 0.75 mg/kg showed the highest SBR (2.06 ± 0.23) after ICG injection. Conclusions Fluorescence quantification based on spectrometry and grayscale imaging could be effective in determining the optimal ICG dose and surgical time after ICG injection in this cohort of patients with oral cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

et al. 2018

View full text Add to dashboard Cite

show abstract

“…No clinical outcomes of these studies are yet available, but some experimental settings have been developed in animal models. For instance, Cheng and colleagues have shown that a surgical navigation system combining optical molecular targets with an ICG-linked molecular probe is able to identify a peritoneal carcinomatosis site as small as 1.8 mm[ 64 ]. On the other hand, reports of some very limited series have shown that after i.v.…”

Section: Peritoneal Carcinomatosismentioning

confidence: 99%

Indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery: State of the art and future directions

Baiocchi

Diana

Boni

2018

WJG

104

View full text Add to dashboard Cite

In recent years, the use of fluorescence-guided surgery (FGS) to treat benign and malignant visceral, hepatobiliary and pancreatic neoplasms has significantly increased. FGS relies on the fluorescence signal emitted by injected substances (fluorophores) after being illuminated by ad hoc laser sources to help guide the surgical procedure and provide the surgeon with real-time visualization of the fluorescent structures of interest that would be otherwise invisible. This review surveys and discusses the most common and emerging clinical applications of indocyanine green (ICG)-based fluorescence in visceral, hepatobiliary and pancreatic surgery. The analysis, findings, and discussion presented here rely on the authors’ significant experience with this technique in their medical institutions, an up-to-date review of the most relevant articles published on this topic between 2014 and 2018, and lengthy discussions with key opinion leaders in the field during recent conferences and congresses. For each application, the benefits and limitations of this technique, as well as applicable future directions, are described. The imaging of fluorescence emitted by ICG is a simple, fast, relatively inexpensive, and harmless tool with numerous different applications in surgery for both neoplasms and benign pathologies of the visceral and hepatobiliary systems. The ever-increasing availability of visual systems that can utilize this tool will transform some of these applications into the standard of care in the near future. Further studies are needed to evaluate the strengths and weaknesses of each application of ICG-based fluorescence imaging in abdominal surgery.

show abstract

“…One series was further not analyzed because the primary outcome was liver metastases detection [7]. Two papers reported the same series [8,9] (Clinical Trial Number 01982227), thus 6 series were nally analyzed [9][10][11][12][13][14].…”

Section: Resultsmentioning

confidence: 99%

Indocyanine Green Fluorescence-guided intraoperative detection of peritoneal carcinomatosis: systematic review.

Baiocchi¹,

Gheza

Molfino

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract BACKGROUND. To review the available clinical data about the value of Indocyanine Green (ICG) fluorescence imaging for intraoperative detection of peritoneal carcinomatosis. METHODS. We conducted a systematic review, according to the PRISMA guidelines, for clinical series investigating the possible role of ICG fluorescence imaging in detecting peritoneal carcinomatosis during surgical treatment of abdominal malignancies. With the aim to analyze actual application in the daily clinical practice, papers including trials with fluorophores other than ICG, in vitro and animals series were excluded. Data on patients and cancer features, timing, dose and modality of ICG administration, sensitivity, specificity and accuracy of fluorescence diagnosis of peritoneal nodules were extracted and analyzed. RESULTS. Out of 192 screened papers, we finally retrieved 7 series reporting ICG-guided detection of peritoneal carcinomatosis. Two papers reported the same cases, thus only 6 series were analyzed, for a total of 71 patients and 353 peritoneal nodules. The investigated tumors were colorectal carcinomas in 28 cases, hepatocellular carcinoma in 16 cases, ovarian cancer in 26 cases and endometrial cancer in 1 case. In all but 4 cases, the clinical setting was an elective intervention in patients known as having peritoneal carcinomatosis. No series reported a laparoscopic procedure. Technical data of ICG management were consistent across the studies. Overall, 353 lesions were harvested and singularly evaluated. Sensitivity varied from 72.4% to 100%, specificity from 54.2% to 100%. Two series reported that planned intervention changed in 25% and 29% of patients, respectively. CONCLUSION. Indocyanine Green based fluorescence of peritoneal carcinomatosis is a promising intraoperative tool for detection and characterization of peritoneal nodules in patients with colorectal, hepatocellular, ovarian carcinomas. Further prospective studies are needed to fix its actual diagnostic value on these and other abdominal malignancies with frequent spread to peritoneum.

show abstract

Fluorescence‐Guided Surgery in the Combined Treatment of Peritoneal Carcinomatosis from Colorectal Cancer: Preliminary Results and Considerations

Abstract: Our results suggest that intraoperative ICG-FI can improve outcomes in patients undergoing CS for PC from CRC. Further studies are needed to determine the role of ICG-FI in this patient population.

Cited by 43 publications

References 40 publications

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

Indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery: State of the art and future directions

Indocyanine Green Fluorescence-guided intraoperative detection of peritoneal carcinomatosis: systematic review.

Contact Info

Product

Resources

About