Impact of a dedicated post-transplant vaccination service at an Australian cancer centre

Teh, Benjamin W; Joyce, Trish; Slavin, Monica A; Thursky, Karin; Worth, Leon J

doi:10.1038/bmt.2017.195

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…45 Clearly, however, there must be barriers to and dedicated post-HSCT vaccination clinics. 47 This was a multicentre study and the sample size and high-response rate (76%) make it likely that these results represent an to participate, we do fail to capture some data from individuals who may derive from diverse ethnic backgrounds. This is an important consideration since culturally and linguistically diverse (CALD) cancer populations often have worse engagement with health services and outcomes than those of their white/Caucasian counterparts, 48 and may be at a disadvantage socioeconomically prior to HSCT.…”

Section: Discussionmentioning

confidence: 97%

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A survey of infectious diseases and vaccination uptake in long‐term hematopoietic stem cell transplant survivors in Australia

Dyer

Gilroy

Brice

et al. 2019

Transplant Infectious Dis

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Background This cross‐sectional survey aimed to establish the prevalence of infectious diseases and vaccination uptake in long‐term allogeneic hematopoietic stem cell transplants (HSCT) survivors in New South Wales, in order to reduce long‐term post‐HSCT morbidity and mortality and enhance long‐term care. Patients and methods Hematopoietic stem cell transplants survivors aged over 18 years and transplanted between 2000‐2012 in New South Wales (NSW) were eligible to participate. Survivors self‐completed the Sydney Post BMT Study survey, FACT‐BMT (V4), Chronic Graft versus Host Disease (cGVHD) Activity Assessment Self Report, Lee Chronic GvHD Symptom Scale, DASS21, Post Traumatic Growth Inventory, and the Fear of Recurrence Scale. Results Of the 583 HSCT survivors contacted, 441 (78%) completed the survey. Respondents included 250 (57%) males and median age was 54 years (range 19‐79 years). The median age at the time of transplant was 49 years (Range: 17‐71), the median time since HSCT was 5 years (Range: 1‐14) and 69% had cGVHD. Collectively, 41.7% of survivors reported a vaccine preventable disease (VPD) with the most common being influenza‐like‐illness (38.4%), varicella zoster/shingles (27.9%), pap smear abnormalities (9.8%), pneumococcal disease (5.1%), and varicella zoster (chicken pox) (4.6%). Only 31.8% had received the full post‐HSCT vaccination schedule, and the majority (69.8%) of these had received the vaccines via their General Practitioner. cGVHD was not found to be a significant factor on multivariate analysis for those who were vaccinated. There was a trend toward lower vaccination rates in patients in a lower income strata. Conclusions Vaccinating post‐HSCT survivors to prevent infections and their consequences have an established role in post‐HSCT care. Improving rates of post‐HSCT vaccination should be a major priority for BMT units.

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Section: Discussionmentioning

confidence: 97%

“…This was not available at the time of survey completion. Other strategies used to increase vaccination adherence and education include vaccination cards and reminder telephone calls, and dedicated post‐HSCT vaccination clinics …”

Section: Discussionmentioning

confidence: 99%

A survey of infectious diseases and vaccination uptake in long‐term hematopoietic stem cell transplant survivors in Australia

Dyer

Gilroy

Brice

et al. 2019

Transplant Infectious Dis

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“…Transplant recipient adherence to vaccination recommendations elsewhere are variable but have not been reported in Australia [ 18 ]. Strategies to improve adherence to vaccinations among recipients include infectious diseases consultation [ 33 ], vaccination clinics [ 34 ], and improved communication [ 17 , 35 ]. Understanding vaccination uptake and effectiveness in this cohort is of increasing relevance with the coronavirus disease 2019 pandemic, and transplant clinicians should be attentive to the full range of vaccines during follow-up.…”

Section: Discussionmentioning

confidence: 99%

Notifiable Infectious Diseases Among Organ Transplant Recipients: A Data-Linked Cohort Study, 2000–2015

Waller

Mata

Wyburn

et al. 2022

Open Forum Infectious Diseases

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Background Infections, including common communicable infections such as influenza, frequently cause disease after organ transplantation, although the quantitative extent of infection and disease remains uncertain. Methods A cohort study was conducted to define the burden of notifiable infectious diseases among all solid organ recipients transplanted in New South Wales, Australia, 2000–2015. Data linkage was used to connect transplant registers to hospital admissions, notifiable diseases, and the death register. Standardized incidence ratios (SIRs) were calculated relative to general population notification rates, accounting for age, sex, and calendar year. Infection-related hospitalizations and deaths were identified. Results Among 4858 solid organ recipients followed for 39 183 person-years (PY), there were 792 notifications. Influenza was the most common infection (532 cases; incidence, 1358 [95% CI, 1247–1478] per 100 000 PY), highest within 3 months posttransplant. Next most common was salmonellosis (46 cases; incidence, 117 [95% CI, 87–156] per 100 000 PY), then pertussis (38 cases; incidence, 97 [95% CI, 71–133] per 100 000 PY). Influenza and invasive pneumococcal disease (IPD) showed significant excess cases compared with the general population (influenza SIR, 8.5 [95% CI, 7.8–9.2]; IPD SIR, 9.8 [95% CI, 6.9–13.9]), with high hospitalization rates (47% influenza cases, 68% IPD cases) and some mortality (4 influenza and 1 IPD deaths). By 10 years posttransplant, cumulative incidence of any vaccine-preventable disease was 12%, generally similar by transplanted organ, except higher among lung recipients. Gastrointestinal diseases, tuberculosis, and legionellosis had excess cases among transplant recipients, although there were few sexually transmitted infections and vector-borne diseases. Conclusions There is potential to avoid preventable infections among transplant recipients with improved vaccination programs, health education, and pretransplant donor and recipient screening.

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“…A strategy to improve vaccination adherence may be to incorporate the option of vaccination during the control visits for the underlying disease at the reference center. 28 Two additional limitations of our study were its monocentric design and our inability to identify the reason for missing or delayed vaccination (fear? Physician's advice?…”

Section: Discussionmentioning

confidence: 99%

Vaccination coverage among paediatric onco-haematological patients: an Italian cross-sectional study

Giordano

Santoro²,

Stefanizzi

et al. 2020

Human Vaccines & Immunotherapeutics

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Children with onco-hematological diseases are at increased risk of infection. However, this risk can in part be controlled or reduced using currently available vaccines. Despite available evidence, in patients diagnosed with a hematological or oncological disease the vaccination schedule is often inappropriately discontinued. In this study we evaluated whether the diagnosis of an oncological or hematological disease is a determinant of noncompliance with recommended vaccinations. The study was carried out between March and April 2019. The population was composed of a convenience sample of 228 children cared for in the Pediatric Oncology Department and Pediatric Hematology Department of the Policlinico Giovanni XXIII Pediatric Hospital (Bari, Italy) from 2005 to 2015. Information on the immunization status of the patients was obtained from the Apulia regional immunization database (GIAVA). A post-diagnosis adherence score was calculated. The vaccination coverage was 87.7% for the DTaP-IPV-Hep B-Hib vaccine (3 doses), 68.7% for the pneumococcal vaccine (3 doses), 75.8% for the MMR vaccine (2 doses) and 75.1% for the varicella vaccine (2 doses). The average age at vaccination was older than that recommended by the National Vaccination Plan. A diagnosis of oncological disease and an older age at enrollment were risk factors for missing vaccinations. These results showed that the overall vaccination status of pediatric onco-hematological patients is suboptimal. Improving provider communication and establishing the hospital as the primary environment for vaccine administration may lead to better vaccination compliance in this group.

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Impact of a dedicated post-transplant vaccination service at an Australian cancer centre

Cited by 8 publications

References 11 publications

A survey of infectious diseases and vaccination uptake in long‐term hematopoietic stem cell transplant survivors in Australia

A survey of infectious diseases and vaccination uptake in long‐term hematopoietic stem cell transplant survivors in Australia

Notifiable Infectious Diseases Among Organ Transplant Recipients: A Data-Linked Cohort Study, 2000–2015

Vaccination coverage among paediatric onco-haematological patients: an Italian cross-sectional study

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