Olfactory toxicity in rats following manganese chloride nasal instillation: A pilot study

Foster, Melanie L.; Rao, Deepa B.; Francher, Taylor; Traver, Samantha; Dorman, David C.

doi:10.1016/j.neuro.2017.09.004

Cited by 16 publications

(10 citation statements)

References 55 publications

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“…The signal intensity of MEMRI generally increases as the MnCl 2 concentration increases, but the signal intensity can be saturated. Moreover, the application of MnCl 2 solutions with excessively high concentrations in the nasal cavity will also cause olfactory damage (81), which is occasionally accompanied by inflammatory reactions (82).…”

Section: Mn 2+ Administration Methodsmentioning

confidence: 99%

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Yang

2020

Front. Neurol.

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Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn 2+. Mn 2+ is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels. Mn 2+ can be transported along the axons of neurons via microtubule-based fast axonal transport. Based on these properties, MEMRI is used to describe neuroanatomical structures, monitor neural activity, and evaluate axonal transport rates. The application of MEMRI in preclinical animal models of central nervous system (CNS) diseases can provide more information for the study of disease mechanisms. In this article, we provide a brief review of MEMRI use in CNS diseases ranging from neurodegenerative diseases to brain injury and spinal cord injury.

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Section: Mn 2+ Administration Methodsmentioning

confidence: 99%

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Yang

2020

Front. Neurol.

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“…The concentration for NaCl and MgCl 2 solutions was used to evaluate their osmotic stress effect on olfactory CaSR‐evoked renal hemodynamic response. One previous study has used an intranasal manganese (200 mmol L −1 MnCl 2 ) treatment to explore olfactory toxicity in rats . Therefore, we selected low 77.5 and high 155 mmol L −1 MnCl 2 in our study.…”

Section: Methodsmentioning

confidence: 99%

Aromatherapy: Activating olfactory calcium‐sensing receptors impairs renal hemodynamics via sympathetic nerve‐mediated vasoconstriction

Lee

Hsiao

et al. 2018

Acta Physiologica

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Calcium-sensing receptor acts as a functional chemosensory receptor on olfactory sensory neuron, and its activation causes the global sympathetic enhancement contributing to systematic vasoconstriction and subsequently depresses renal blood flow and glomerular filtration rate. These data implicate a possibly clinical aspect that several environmental stimuli may activate olfactory calcium-sensing receptors to evoke a sympathetic nervous system-mediated neurovascular reflex to depress renal hemodynamics.

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“…In the process, manganese accumulates in the olfactory bulb and can be detected after 12 weeks throughout the brain and spinal cord [68–71]. Transport of the manganese from the nasal cavities into the brain requires the axonal projections of the olfactory epithelium’s receptor neurons to be intact [72].…”

Section: Industrial Chemicals With a Potential Impact Upon Olfactionmentioning

confidence: 99%

“…Foster et al also evaluated the transport of manganese from the olfactory epithelium to the olfactory bulb: a bilateral instillation of 40 μl 200 mM MnCl 2 in rats leads to an increase in manganese levels in both the olfactory epithelium and the olfactory bulb, and the rats exposed to manganese exhibit decreased performance in the olfactory discrimination task. Manganese accumulation in the olfactory bulb and in other regions of the brain was also demonstrated by MRT studies on non-human primates exposed to aerosolised MnSO 4 (≥ 0.06 mg Mn/m 3 ) [71]. …”

Section: Industrial Chemicals With a Potential Impact Upon Olfactionmentioning

confidence: 99%

Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals

Werner

Nies

2018

J Occup Med Toxicol

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Occupational exposure to numerous individual chemicals has been associated with olfactory dysfunction, mainly in individual case descriptions. Comprehensive epidemiological investigations into the olfactotoxic effect of working substances show that the human sense of smell may be impaired by exposure to metal compounds involving cadmium, chromium and nickel, and to formaldehyde. This conclusion is supported by the results of animal experiments. The level of evidence for a relationship between olfactory dysfunction and workplace exposure to other substances is relatively weak.

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Olfactory toxicity in rats following manganese chloride nasal instillation: A pilot study

Cited by 16 publications

References 55 publications

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Aromatherapy: Activating olfactory calcium‐sensing receptors impairs renal hemodynamics via sympathetic nerve‐mediated vasoconstriction

Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals

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