Effectiveness of the critical congenital heart disease screening program for early diagnosis of cardiac abnormalities in newborn infants

Almawazini, Abdulmajid; Hanafi, Hamdi K; Madkhali, Hasan A; Majrashi, Noura B

doi:10.15537/smj.2017.10.20295

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…The predominant language in which the studies were published was English and the type of study was observational, retrospective and prospective. Nine studies (20)(21)(22)25,29,30,33,39,43,44) followed a protocol to perform the test in the first 24 hours, and the others from 24 hours after birth to 48 hours.…”

Section: Resultsmentioning

confidence: 99%

Pulse oximetry test for screening congenital heart diseases: a systematic review

Saganski,

Freire,

Santos

2023

Rev. esc. enferm. USP

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Objective: To determine the accuracy of the Pulse Oximetry Test (POT) in screening for Congenital Heart Diseases (CHD) in newborns in the first 48 hours of life. Method: Systematic review of diagnostic test accuracy with meta-analysis. The selection of studies was carried out in June 2021. Studies were selected with newborns, in a hospital or home environment, without a previous diagnosis of CHD, regardless of gestational age at birth, who underwent POT within the first 48 hours after birth. Registration on the PROSPERO platform – CRD42021256286. Results: Twenty-nine studies were included, totaling a population of 388,491 newborns. POT demonstrated sensitivity of 47% (95% CI: 43% to 50%) and specificity of 98% (95% CI: 98% to 98%). Subgroup analyses were carried out according to the different testing period, inclusion of retests in protocols and population of premature newborns. Conclusion: POT is a test with moderate sensitivity and high specificity. It is more effective when carried out within 24h – 48h of birth; in protocols that present retests, within two hours after the first measurement. It does not show satisfactory effectiveness for premature newborns.

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Section: Resultsmentioning

confidence: 99%

Pulse oximetry test for screening congenital heart diseases: a systematic review

Saganski,

Freire,

Santos

2023

Rev. esc. enferm. USP

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“…O idioma predominante de publicação dos estudos foi o inglês e o tipo de estudo foi observacional, retrospectivo e prospectivo. Nove estudos (20)(21)(22)25,29,30,33,39,43,44) seguiram um protocolo para realização do teste nas primeiras 24 horas, e os demais a partir de 24 horas do nascimento até 48 horas.…”

Section: Resultsunclassified

Teste de oximetria de pulso para triagem de cardiopatias congênitas: revisão sistemática

Saganski,

Freire,

Santos

2023

Rev. esc. enferm. USP

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RESUMO Objetivo: Determinar a acurácia do Teste de Oximetria de Pulso (TOP) na triagem de Cardiopatias Congênitas (CC) em recém-nascidos nas primeiras 48 horas de vida. Método: Revisão sistemática de acurácia de teste diagnóstico com metanálise. A seleção dos estudos foi realizada em junho de 2021. Foram selecionados estudos com recém-nascidos, em ambiente hospitalar ou domiciliar, sem o diagnóstico prévio de CC, independentemente da idade gestacional ao nascimento, que realizaram o TOP entre as primeiras 48h após o nascimento. Registro na plataforma PROSPERO – CRD42021256286. Resultados: Foram incluídos 29 estudos, somando uma população total de 388.491 recém-nascidos. O TOP demonstrou sensibilidade de 47% (IC 95%: 43% a 50%) e especificidade de 98% (IC 95%: 98% a 98%). Foram realizadas análises dos subgrupos conforme período de realização do teste diferente, inclusão de retestes nos protocolos e população de recém-nascidos prematuros. Conclusão: O TOP é um teste de moderada sensibilidade e alta especificidade. Apresenta maior efetividade quando realizado no intervalo entre 24h – 48h do nascimento; em protocolos que apresentem retestes, em até duas horas após a primeira medida. Não apresenta efetividade satisfatória para recém-nascidos prematuros.

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“…This study’s false-positive rate of 0.6% is slightly higher to Norway’s 0.14% [ 23 ], or German’s 0.1% [ 16 ] but comparable to the UK’s 0.8% [ 18 ]. Poland’s 0.026 [ 16 ] is the lowest rate while Saudi Arabia’s 3.4% and Ethiopia’s 6% [ 24 25 ] top the list. Observed differences in false positive rates are basically due to prevalence and the timing for CCHD screening.…”

Section: Discussionmentioning

confidence: 99%

Newborn Screening for Critical Congenital Heart Disease in a Low-Resource Setting; Research Protocol and Preliminary Results of the Tanzania Pulse Oximetry Study

Majani

Chillo

Slieker

et al. 2022

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Background: Critical Congenital Heart Disease (CCHD) is the leading cause of early new-born mortality. Its early detection and intervention is crucial for the survival of affected new-born. Pulse Oximetry (POX) has shown to be one of the feasible, accurate and cost-effective tools in screening CCHD in developed nations, it is yet to be practiced and established as standard of care in a low-resource setting. Objectives: This paper reports on the research protocol and preliminary results of an ongoing study regarding the performance of POX in detecting CCHD in new-borns in a low resource setting. Secondary objectives include investigating the burdens of CCHD and outcome at 12 months of age. Methods: The Tanzanian Pulse Oximetry Study (TPOXS) is a prospective cohort study which plans to enrol 30,000 mothers and new-borns delivered at two referral hospitals in Tanzania. New-borns are offered POX test 12 hours after birth, those positively undergoes echocardiography examinations. Confirmed with CCHD are placed under observation for up to first birthday. Results: During a 5-months pilot period, a total of 1,592 infants at the Muhimbili National Hospital, received POX test .65% of them were post-caesarean section and 52% being male. Most babies delivered through Spontaneous Vertex Delivery (SVD) were promptly discharge and did not get screened. The detection-rate of CCHD was 2.5 per 1,000 live births (at 95% confidence interval [CI] 0.9 to 6.7 per 1000 live birth); with a POX false positive rate of 0.6%. Seven false-positive infants out of 10 were found to carry significant other neonatal conditions, including persistent pulmonary hypertension of the new-born, transient tachypnoeic and neonatal sepsis. Conclusion: This paper provides the protocol of the ongoing TPOXS with the preliminary results showing prevalence matching closely the global data. It shows acceptability of POX screening for CCHD in a well-prepared low resource setting. Highlight: This study addresses the utilization of pulse oximeter in detecting critical congenital heart disease (CCHD) in a low-resource setting (such as sub-Saharan African countries).

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Effectiveness of the critical congenital heart disease screening program for early diagnosis of cardiac abnormalities in newborn infants

Cited by 7 publications

References 15 publications

Pulse oximetry test for screening congenital heart diseases: a systematic review

Pulse oximetry test for screening congenital heart diseases: a systematic review

Teste de oximetria de pulso para triagem de cardiopatias congênitas: revisão sistemática

Newborn Screening for Critical Congenital Heart Disease in a Low-Resource Setting; Research Protocol and Preliminary Results of the Tanzania Pulse Oximetry Study

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